Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
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BT-20 | Sirolimus | 2 | 72 | flat | flat | BT20 rapamycin 0 2 72 | 8 | 1.952 | Inf | 0.421 | 0.579 | 0.0 | 0.421 | 0.01 | NA | NA | 0.421 | Inf | 0.513 | 0.513 | 0.0 | 0.513 | 0.01 | NA | NA | 0.513 |
BT-20 | Everolimus | 2 | 72 | flat | flat | BT20 everolimus 0 2 72 | 8 | 1.785 | Inf | 0.426 | 0.574 | 0.0 | 0.426 | 0.01 | NA | NA | 0.426 | Inf | 0.547 | 0.547 | 0.0 | 0.547 | 0.01 | NA | NA | 0.547 |
BT-20 | Sirolimus | 3 | 72 | flat | flat | BT20 rapamycin 0 3 72 | 8 | 2.661 | Inf | 0.54 | 0.46 | 0.0 | 0.54 | 0.01 | NA | NA | 0.54 | Inf | 0.499 | 0.499 | 0.0 | 0.499 | 0.01 | NA | NA | 0.499 |
HCC1806 | Omipalisib | 3 | 72 | sigmoid | sigmoid | HCC1806 omipalisib 0 3 72 | 8 | 3.217 | 0.147 | -0.221 | 0.437 | 0.71 | -0.707 | 0.559 | 0.981 | 7.41e-06 | NA | 0.0642 | 0.0481 | 0.54 | 0.0538 | 0.0749 | 0.919 | 0.979 | 9.93e-06 | NA |
HCC1806 | Omipalisib | 2 | 72 | sigmoid | sigmoid | HCC1806 omipalisib 0 2 72 | 8 | 2.849 | 0.112 | -0.311 | 0.479 | 0.543 | -0.739 | 0.573 | 0.98 | 8.07e-06 | NA | 0.0642 | 0.0481 | 0.54 | 0.0538 | 0.0749 | 0.919 | 0.979 | 9.93e-06 | NA |
HCC1806 | Omipalisib | 1 | 72 | sigmoid | sigmoid | HCC1806 omipalisib 0 1 72 | 8 | 2.764 | 0.104 | -0.333 | 0.49 | 0.508 | -0.746 | 0.577 | 0.98 | 8.23e-06 | NA | 0.0642 | 0.0481 | 0.54 | 0.0538 | 0.0749 | 0.919 | 0.979 | 9.93e-06 | NA |
HCC70 | Dactolisib | 2 | 72 | sigmoid | sigmoid | HCC70 dactolisib 0 2 72 | 8 | 1.677 | 0.312 | 0.238 | 0.341 | 0.195 | 0.103 | 0.493 | 0.954 | 9.66e-05 | NA | 2.24 | 0.447 | 0.738 | 0.0858 | 0.419 | 0.56 | 0.954 | 9.8e-05 | NA |
Hs 578T | CAL-101 | 3 | sigmoid | sigmoid | Hs578T idelalisib 3 | 8 | 2.874 | Inf | 0.854 | 0.0202 | 1.12 | 0.835 | 1.91 | 0.991 | 6.68e-07 | NA | Inf | 0.805 | 0.972 | 1.07 | 0.781 | 1.92 | 0.99 | 9.77e-07 | NA | |
Hs 578T | GDC-0980 | 3 | sigmoid | sigmoid | Hs578T apitolisib 3 | 8 | 2.831 | 0.243 | 0.145 | 0.315 | 0.19 | 0.112 | 1.02 | 0.998 | 4.02e-09 | NA | 0.179 | 0.206 | 0.665 | 0.114 | 0.196 | 1.09 | 0.999 | 9.76e-10 | NA | |
BT-20 | Dactolisib | 1 | 72 | sigmoid | sigmoid | BT20 dactolisib 0 1 72 | 8 | 2.055 | 0.0223 | -0.205 | 0.652 | 0.0609 | -0.33 | 0.505 | 0.979 | 9.18e-06 | NA | 0.0305 | 0.15 | 0.475 | 0.0171 | 0.153 | 0.631 | 0.979 | 9.75e-06 | NA |
BT-549 | AZD8055 | 3 | 72 | sigmoid | sigmoid | BT549 AZD8055 0 3 72 | 8 | 1.757 | 0.0178 | 0.159 | 0.59 | 0.0122 | 0.145 | 0.913 | 0.942 | 0.000193 | NA | 0.0479 | 0.383 | 0.555 | 0.00973 | 0.372 | 0.854 | 0.954 | 9.74e-05 | NA |
Hs 578T | PIK-93 | 1 | sigmoid | sigmoid | Hs578T PIK-93 1 | 8 | 2.033 | 1.44 | 0.276 | 0.175 | 8.38 | -1.0 | 0.624 | 0.991 | 6.57e-07 | NA | 2.0 | 0.401 | 0.84 | 2.0 | 0.0 | 0.672 | 0.99 | 9.72e-07 | NA | |
BT-549 | Torin1 | 2 | 72 | sigmoid | sigmoid | BT549 Torin1 0 2 72 | 8 | 1.881 | 0.0165 | 0.0298 | 0.618 | 0.0147 | 0.0572 | 1.03 | 0.993 | 4.2e-07 | NA | 0.0262 | 0.287 | 0.52 | 0.0111 | 0.306 | 1.1 | 0.99 | 9.68e-07 | NA |
HCC38 | WYE-125132 | 3 | 72 | sigmoid | sigmoid | HCC38 WYE-132 0 3 72 | 8 | 1.449 | 0.0494 | -0.0216 | 0.518 | 0.0504 | -0.0117 | 1.18 | 0.998 | 9.69e-09 | NA | 0.128 | 0.355 | 0.662 | 0.0441 | 0.361 | 1.2 | 0.998 | 9.53e-09 | NA |
BT-549 | Torin1 | 1 | 72 | sigmoid | sigmoid | BT549 Torin1 0 1 72 | 8 | 1.794 | 0.017 | 0.0603 | 0.621 | 0.0151 | 0.056 | 0.976 | 0.998 | 7.25e-09 | NA | 0.0333 | 0.32 | 0.532 | 0.0118 | 0.316 | 0.966 | 0.998 | 9.27e-09 | NA |
BT-549 | ZSTK474 | 3 | 72 | sigmoid | sigmoid | BT549 ZSTK474 0 3 72 | 8 | 1.776 | 0.504 | 0.139 | 0.267 | 0.616 | -0.0912 | 0.836 | 0.996 | 7.06e-08 | NA | 0.994 | 0.368 | 0.789 | 0.489 | 0.218 | 0.808 | 0.995 | 9.19e-08 | NA |
BT-20 | Dactolisib | 3 | 72 | sigmoid | sigmoid | BT20 dactolisib 0 3 72 | 8 | 2.420 | 0.0111 | 0.024 | 0.639 | 0.00921 | 0.0987 | 1.17 | 0.982 | 6.27e-06 | NA | 0.0106 | 0.198 | 0.427 | 0.00645 | 0.241 | 1.32 | 0.99 | 9.14e-07 | NA |
HCC38 | PIK-93 | 1 | 72 | sigmoid | sigmoid | HCC38 PIK-93 0 1 72 | 8 | 1.741 | 5.24 | 0.61 | 0.0782 | 24.5 | -1.0 | 0.713 | 0.982 | 6.07e-06 | NA | 9.93 | 0.686 | 0.935 | 9.93 | 0.0 | 0.729 | 0.979 | 9.08e-06 | NA |
BT-20 | MK2206 | 3 | 72 | sigmoid | sigmoid | BT20 MK-2206 0 3 72 | 8 | 2.449 | 1.73 | 0.252 | 0.12 | 3.23 | -0.504 | 1.11 | 0.988 | 1.77e-06 | NA | 1.69 | 0.318 | 0.877 | 1.69 | 0.0 | 1.18 | 0.979 | 9.03e-06 | NA |
BT-549 | Buparlisib | 2 | 72 | sigmoid | sigmoid | BT549 buparlisib 0 2 72 | 8 | 1.913 | 0.681 | -0.306 | 0.217 | 1.08 | -0.538 | 1.59 | 0.998 | 1.31e-08 | NA | 0.821 | 0.132 | 0.838 | 0.769 | 0.0514 | 1.66 | 0.996 | 8.95e-08 | NA |
Hs 578T | Alpelisib | 3 | sigmoid | sigmoid | Hs578T alpelisib 3 | 8 | 2.856 | Inf | 0.712 | 0.0759 | 0.872 | 0.616 | 0.828 | 0.963 | 5.21e-05 | NA | Inf | 0.641 | 0.901 | 0.65 | 0.553 | 0.853 | 0.955 | 8.85e-05 | NA | |
HCC1806 | WYE-125132 | 2 | 72 | sigmoid | sigmoid | HCC1806 WYE-132 0 2 72 | 8 | 2.874 | 0.872 | 0.479 | 0.284 | 0.045 | 0.464 | 0.883 | 0.997 | 3.66e-08 | NA | 0.226 | 0.42 | 0.663 | 0.0335 | 0.402 | 0.855 | 0.996 | 8.79e-08 | NA |
HCC1806 | WYE-125132 | 1 | 72 | sigmoid | sigmoid | HCC1806 WYE-132 0 1 72 | 8 | 2.790 | 0.603 | 0.466 | 0.292 | 0.0448 | 0.45 | 0.883 | 0.997 | 3.72e-08 | NA | 0.226 | 0.42 | 0.663 | 0.0335 | 0.402 | 0.855 | 0.996 | 8.79e-08 | NA |
HCC1806 | WYE-125132 | 3 | 72 | sigmoid | sigmoid | HCC1806 WYE-132 0 3 72 | 8 | 3.242 | Inf | 0.531 | 0.255 | 0.0458 | 0.517 | 0.885 | 0.997 | 3.48e-08 | NA | 0.226 | 0.42 | 0.663 | 0.0335 | 0.402 | 0.855 | 0.996 | 8.79e-08 | NA |
Hs 578T | Torin1 | 1 | sigmoid | sigmoid | Hs578T Torin1 1 | 8 | 1.956 | 0.0217 | 0.0183 | 0.598 | 0.0203 | 0.0286 | 0.911 | 0.994 | 1.81e-07 | NA | 0.0321 | 0.267 | 0.524 | 0.0141 | 0.28 | 0.995 | 0.996 | 8.78e-08 | NA |