The Harvard Medical School (HMS) Library of Integrated Network-based Cellular Signatures (LINCS) Center was established in October 2010 as one of two research centers in the US creating libraries of signatures that describe how cells respond to perturbation. The other LINCS Center is at the Broad Institute. The aim of the HMS Center is to create signatures that measure responses to therapeutic drugs of cells derived from different human tissues. Much of our work is on tumor cells (from breast, liver and colon), but we also study primary human cells from normal and diseased patients. As perturbing agents, our focus is on small molecule kinase inhibitors, which are a leading class of therapeutic agents for treatment of cancer, autoimmune and other diseases. Overall, in our center, the responses of approximately 800 cell lines/cell types to around 200 small molecules and cytokines are under investigation in a variety of biochemical and cell biological assays.
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