Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
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BT-20 | Torin2 | 2 | 72 | sigmoid | sigmoid | BT20 Torin2 0 2 72 | 8 | 1.733 | 0.00315 | -0.761 | 0.992 | 0.0484 | -0.95 | 0.389 | 0.949 | 0.000131 | NA | 0.00804 | 0.0252 | 0.336 | 0.00642 | 0.0613 | 0.583 | 0.974 | 1.77e-05 | NA |
BT-20 | Omipalisib | 2 | 72 | sigmoid | sigmoid | BT20 omipalisib 0 2 72 | 8 | 1.717 | 0.00324 | -0.799 | 1.1 | 0.00361 | -0.354 | 4.99 | 0.808 | 0.00704 | NA | 0.00518 | 0.0194 | 0.291 | 0.00429 | 0.111 | 1.34 | 0.968 | 3.16e-05 | NA |
Hs 578T | Trametinib | 1 | sigmoid | sigmoid | Hs578T trametinib 1 | 8 | 2.044 | 0.00353 | -0.00904 | 0.765 | 0.00516 | -0.0906 | 0.437 | 0.992 | 4.85e-07 | NA | 0.00661 | 0.238 | 0.385 | 0.00213 | 0.201 | 0.456 | 0.993 | 3e-07 | NA | |
HCC70 | Omipalisib | 1 | 72 | sigmoid | sigmoid | HCC70 omipalisib 0 1 72 | 8 | 1.358 | 0.00496 | -0.785 | 1.14 | 0.0157 | -0.775 | 0.812 | 0.989 | 1.34e-06 | NA | 0.0123 | 0.0486 | 0.349 | 0.011 | 0.0462 | 0.833 | 0.984 | 3.73e-06 | NA |
BT-20 | Dactolisib | 2 | 72 | sigmoid | sigmoid | BT20 dactolisib 0 2 72 | 8 | 1.727 | 0.00497 | -0.212 | 0.896 | 0.00652 | -0.186 | 1.17 | 0.995 | 1.45e-07 | NA | 0.00801 | 0.2 | 0.382 | 0.00505 | 0.211 | 1.19 | 0.994 | 2.07e-07 | NA |
Hs 578T | Omipalisib | 1 | sigmoid | sigmoid | Hs578T omipalisib 1 | 8 | 2.079 | 0.00552 | -0.546 | 0.842 | 0.17 | -1.0 | 0.321 | 0.98 | 8.1e-06 | NA | 0.0079 | 0.0459 | 0.351 | 0.0079 | 0.0 | 0.369 | 0.984 | 4.12e-06 | NA | |
BT-549 | Dactolisib | 3 | 72 | sigmoid | sigmoid | BT549 dactolisib 0 3 72 | 8 | 1.801 | 0.0058 | -0.00929 | 0.751 | 0.00579 | 0.000747 | 0.866 | 0.994 | 2.41e-07 | NA | 0.011 | 0.282 | 0.442 | 0.00425 | 0.29 | 0.909 | 0.995 | 1.54e-07 | NA |
BT-20 | Omipalisib | 1 | 72 | sigmoid | sigmoid | BT20 omipalisib 0 1 72 | 8 | 2.078 | 0.00617 | -0.729 | 0.985 | 0.0283 | -0.739 | 0.596 | 0.97 | 2.83e-05 | NA | 0.00781 | 0.0157 | 0.306 | 0.00685 | 0.0597 | 0.96 | 0.988 | 1.57e-06 | NA |
Hs 578T | Trametinib | 2 | sigmoid | sigmoid | Hs578T trametinib 2 | 8 | 2.483 | 0.00633 | 0.074 | 0.701 | 0.00558 | 0.0362 | 0.593 | 0.998 | 1.32e-08 | NA | 0.0058 | 0.214 | 0.361 | 0.00257 | 0.193 | 0.602 | 0.998 | 3.66e-09 | NA | |
BT-20 | Omipalisib | 3 | 72 | sigmoid | sigmoid | BT20 omipalisib 0 3 72 | 8 | 2.586 | 0.00689 | -0.587 | 0.893 | 0.044 | -0.714 | 0.478 | 0.958 | 7.32e-05 | NA | 0.00572 | 0.017 | 0.281 | 0.00491 | 0.0669 | 0.945 | 0.983 | 4.7e-06 | NA |
HCC70 | Omipalisib | 2 | 72 | sigmoid | sigmoid | HCC70 omipalisib 0 2 72 | 8 | 1.682 | 0.00746 | -0.705 | 1.01 | 0.0241 | -0.703 | 0.749 | 0.991 | 6.69e-07 | NA | 0.0135 | 0.0399 | 0.359 | 0.0121 | 0.0458 | 0.852 | 0.989 | 1.45e-06 | NA |
BT-20 | Torin1 | 2 | 72 | sigmoid | sigmoid | BT20 Torin1 0 2 72 | 8 | 1.793 | 0.00766 | -0.152 | 0.806 | 0.00992 | -0.146 | 0.986 | 0.986 | 2.59e-06 | NA | 0.0131 | 0.215 | 0.421 | 0.00727 | 0.212 | 0.936 | 0.988 | 1.92e-06 | NA |
BT-549 | Torin2 | 3 | 72 | sigmoid | sigmoid | BT549 Torin2 0 3 72 | 8 | 1.613 | 0.00797 | -0.254 | 0.794 | 0.0216 | -0.338 | 0.517 | 0.98 | 8.52e-06 | NA | 0.0236 | 0.204 | 0.458 | 0.0104 | 0.191 | 0.585 | 0.976 | 1.3e-05 | NA |
HCC38 | Dactolisib | 3 | 72 | sigmoid | sigmoid | HCC38 dactolisib 0 3 72 | 8 | 1.468 | 0.0082 | -0.197 | 0.778 | 0.0127 | -0.181 | 0.711 | 0.993 | 3.98e-07 | NA | 0.0268 | 0.262 | 0.497 | 0.00923 | 0.277 | 0.757 | 0.994 | 2.62e-07 | NA |
BT-20 | AZD8055 | 2 | 72 | sigmoid | sigmoid | BT20 AZD8055 0 2 72 | 8 | 1.951 | 0.00909 | 0.155 | 0.651 | 0.00651 | 0.115 | 0.785 | 0.936 | 0.000258 | NA | 0.0185 | 0.343 | 0.477 | 0.00469 | 0.311 | 0.706 | 0.934 | 0.000289 | NA |
BT-549 | Torin2 | 1 | 72 | sigmoid | sigmoid | BT549 Torin2 0 1 72 | 8 | 1.771 | 0.0095 | -0.218 | 0.756 | 0.0155 | -0.193 | 0.672 | 0.985 | 3.06e-06 | NA | 0.0183 | 0.19 | 0.452 | 0.00874 | 0.218 | 0.775 | 0.988 | 1.88e-06 | NA |
Hs 578T | Dactolisib | 1 | sigmoid | sigmoid | Hs578T dactolisib 1 | 8 | 2.047 | 0.00952 | -0.0606 | 0.691 | 0.00928 | 0.0117 | 0.91 | 0.977 | 1.27e-05 | NA | 0.0124 | 0.213 | 0.443 | 0.00621 | 0.259 | 1.06 | 0.985 | 3.61e-06 | NA | |
BT-549 | Dactolisib | 1 | 72 | sigmoid | sigmoid | BT549 dactolisib 0 1 72 | 8 | 1.840 | 0.00961 | -0.00769 | 0.683 | 0.00888 | 0.0384 | 1.01 | 0.985 | 3.53e-06 | NA | 0.0161 | 0.275 | 0.482 | 0.0068 | 0.303 | 1.09 | 0.987 | 2.38e-06 | NA |
BT-549 | Dactolisib | 2 | 72 | sigmoid | sigmoid | BT549 dactolisib 0 2 72 | 8 | 1.889 | 0.00968 | -0.00862 | 0.677 | 0.00884 | 0.0542 | 1.27 | 0.985 | 3.3e-06 | NA | 0.0134 | 0.266 | 0.48 | 0.00701 | 0.305 | 1.45 | 0.988 | 1.53e-06 | NA |
BT-549 | Torin2 | 2 | 72 | sigmoid | sigmoid | BT549 Torin2 0 2 72 | 8 | 1.824 | 0.00997 | -0.281 | 0.767 | 0.0212 | -0.282 | 0.594 | 0.975 | 1.47e-05 | NA | 0.0177 | 0.155 | 0.438 | 0.00929 | 0.188 | 0.734 | 0.973 | 2.02e-05 | NA |
BT-549 | Omipalisib | 2 | 72 | sigmoid | sigmoid | BT549 omipalisib 0 2 72 | 8 | 1.990 | 0.0104 | -0.291 | 0.751 | 0.026 | -0.32 | 0.542 | 0.966 | 4.09e-05 | NA | 0.0175 | 0.127 | 0.422 | 0.011 | 0.118 | 0.58 | 0.953 | 0.000102 | NA |
HCC38 | Dactolisib | 1 | 72 | sigmoid | sigmoid | HCC38 dactolisib 0 1 72 | 8 | 1.821 | 0.0109 | -0.0403 | 0.672 | 0.0104 | 0.0212 | 0.892 | 0.985 | 3.44e-06 | NA | 0.0194 | 0.263 | 0.492 | 0.00757 | 0.301 | 0.975 | 0.988 | 1.65e-06 | NA |
BT-20 | Dactolisib | 3 | 72 | sigmoid | sigmoid | BT20 dactolisib 0 3 72 | 8 | 2.420 | 0.0111 | 0.024 | 0.639 | 0.00921 | 0.0987 | 1.17 | 0.982 | 6.27e-06 | NA | 0.0106 | 0.198 | 0.427 | 0.00645 | 0.241 | 1.32 | 0.99 | 9.14e-07 | NA |
BT-549 | Omipalisib | 3 | 72 | sigmoid | sigmoid | BT549 omipalisib 0 3 72 | 8 | 1.777 | 0.0114 | -0.23 | 0.753 | 0.0162 | -0.178 | 0.879 | 0.988 | 1.64e-06 | NA | 0.0201 | 0.183 | 0.459 | 0.0112 | 0.208 | 0.924 | 0.991 | 6.53e-07 | NA |
Hs 578T | Dactolisib | 3 | sigmoid | sigmoid | Hs578T dactolisib 3 | 8 | 2.837 | 0.0118 | 0.0569 | 0.624 | 0.00848 | 0.115 | 0.799 | 0.96 | 6.53e-05 | NA | 0.00728 | 0.164 | 0.377 | 0.0043 | 0.212 | 1.05 | 0.968 | 3.34e-05 | NA |