Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

Data Columns

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Name Description Display Name Data Type Unit Precision Readout Type Replicate Comments
cellLine
cell reagent
Cell line cell
treatment
small molecule perturbagen
Drug name small_molecule
replicate
experimental replicate number
Experimental replicate Numeric 0
time
timepoint at which treatment response was analyzed
Timepoint Numeric hr 0
fitGr
type of curve used to fit the GR values (sigmoid, biphasic, flat)
Curve type (GR values) Text
fitRelCell
type of curve used to fit the relative cell counts (sigmoid, biphasic, flat)
Curve type (relative cell counts) Text
experiment
experiment name based on cell line, drug and experimental replicate
Experiment name Text
concentrationPoints
number of drug concentrations evaluated (½ log dilution series)
Number of concentrations Numeric 0
ctrlCellDoublings
average number of doublings for DMSO-treated cells over the course of the assay
Cell doublings (DMSO control) Numeric 3
GR50
drug concentration at which the GR value = 0.5, based on the the curve used to fit GR values for treatment versus control
GR50 Text uM
GRmax
the GR value at the highest concentration of drug tested
GRmax Text
grAoc
the area over the curve used to fit the GR values for treatment versus control (integral of 1–GR over the range of concentrations tested)
GR_AOC Text
GEC50
drug concentration at half of its maximal effect, based on the curve used to fit GR values for treatment versus control
GEC50 Text uM
GRinf
the estimated effect of the drug at infinite concentration, based on the asymptote of the curve used to fit GR values for treatment versus control
GRinf Text
hGr
the hill coefficient (slope) of the curve used to fit GR values for treatment versus control
Hill slope (GR values) Text
r2Gr
r^2 value for the sigmoid curve used to fit GR values for treatment versus control
R-squared sigmoid fit (GR values) Text
pvalGr
statistical significance of the sigmoid curve fit based on an F-test
P-value sigmoid fit (GR values) Text
flatFitGr
r^2 value for the flat fit for GR values (when a sigmoid cannot be fit)
R-squared flat fit (GR values) Text
IC50
drug concentration producing 50% relative cell count versus DMSO control
IC50 Text uM
Emax
maximal measured efficacy in terms of % relative cell count versus DMSO control
Emax Text
AUC
area under the curve used to fit the relative cell count values for treatment versus control
AUC Text
EC50
drug concentration producing half of its maximal effect, based on the curve used to fit relative cell counts for treatment versus control
EC50 Text uM
Einf
estimated maximal efficacy based on the asymptote of the curve used to fit relative cell counts for treatment versus control
Einf Text
h
the hill coefficient (slope) of the curve used to fit relative cell counts for treatment versus control
Hill slope (relative cell counts) Text
r2RelCell
r^2 value for the sigmoid curve used to fit relative cell counts for treatment versus control
R-squared sigmoid fit (relative cell counts) Text
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  • 1 to 25 of 27 Data Columns