## Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

## Data Columns

Download: Excel (XLSX), Comma-separated (CSV)

Name | Description | Display Name | Data Type | Unit | Precision | Readout Type | Replicate | Comments |
---|---|---|---|---|---|---|---|---|

cellLine | cell reagent | Cell line | cell | |||||

treatment | small molecule perturbagen | Drug name | small_molecule | |||||

replicate | experimental replicate number | Experimental replicate | Numeric | 0 | ||||

time | timepoint at which treatment response was analyzed | Timepoint | Numeric | hr | 0 | |||

fitGr | type of curve used to fit the GR values (sigmoid, biphasic, flat) | Curve type (GR values) | Text | |||||

fitRelCell | type of curve used to fit the relative cell counts (sigmoid, biphasic, flat) | Curve type (relative cell counts) | Text | |||||

experiment | experiment name based on cell line, drug and experimental replicate | Experiment name | Text | |||||

concentrationPoints | number of drug concentrations evaluated (½ log dilution series) | Number of concentrations | Numeric | 0 | ||||

ctrlCellDoublings | average number of doublings for DMSO-treated cells over the course of the assay | Cell doublings (DMSO control) | Numeric | 3 | ||||

GR50 | drug concentration at which the GR value = 0.5, based on the the curve used to fit GR values for treatment versus control | GR50 | Text | uM | ||||

GRmax | the GR value at the highest concentration of drug tested | GRmax | Text | |||||

grAoc | the area over the curve used to fit the GR values for treatment versus control (integral of 1–GR over the range of concentrations tested) | GR_AOC | Text | |||||

GEC50 | drug concentration at half of its maximal effect, based on the curve used to fit GR values for treatment versus control | GEC50 | Text | uM | ||||

GRinf | the estimated effect of the drug at infinite concentration, based on the asymptote of the curve used to fit GR values for treatment versus control | GRinf | Text | |||||

hGr | the hill coefficient (slope) of the curve used to fit GR values for treatment versus control | Hill slope (GR values) | Text | |||||

r2Gr | r^2 value for the sigmoid curve used to fit GR values for treatment versus control | R-squared sigmoid fit (GR values) | Text | |||||

pvalGr | statistical significance of the sigmoid curve fit based on an F-test | P-value sigmoid fit (GR values) | Text | |||||

flatFitGr | r^2 value for the flat fit for GR values (when a sigmoid cannot be fit) | R-squared flat fit (GR values) | Text | |||||

IC50 | drug concentration producing 50% relative cell count versus DMSO control | IC50 | Text | uM | ||||

Emax | maximal measured efficacy in terms of % relative cell count versus DMSO control | Emax | Text | |||||

AUC | area under the curve used to fit the relative cell count values for treatment versus control | AUC | Text | |||||

EC50 | drug concentration producing half of its maximal effect, based on the curve used to fit relative cell counts for treatment versus control | EC50 | Text | uM | ||||

Einf | estimated maximal efficacy based on the asymptote of the curve used to fit relative cell counts for treatment versus control | Einf | Text | |||||

h | the hill coefficient (slope) of the curve used to fit relative cell counts for treatment versus control | Hill slope (relative cell counts) | Text | |||||

r2RelCell | r^2 value for the sigmoid curve used to fit relative cell counts for treatment versus control | R-squared sigmoid fit (relative cell counts) | Text |