Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

Filter results: >>>>
  • Page 1 of 18
  • 1 to 25 of 432 records
Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
BT-20 TGX221 1 72
flat
flat
BT20 TGX-221 0 1 72
8 1.988
Inf
1.02
-0.00357
0.0
1.02
0.01
-0.00762
1.0
1.0
Inf
1.02
1.0
0.0
1.02
0.01
-0.00881
1.0
1.0
BT-20 XL147 1 72
flat
flat
BT20 pilaralisib 0 1 72
8 2.128
Inf
0.815
0.048
0.0
0.815
0.01
0.411
0.205
0.939
Inf
0.813
0.95
0.0
0.813
0.01
0.383
0.234
0.937
BT-20 PI103 1 72
sigmoid
sigmoid
BT20 PI-103 0 1 72
8 1.924
0.646
-0.0114
0.16
0.659
-0.0268
2.6
0.978
1.1e-05
NA
0.753
0.258
0.883
0.579
0.252
2.68
0.964
4.79e-05
NA
BT-20 Everolimus 1 72
flat
flat
BT20 everolimus 0 1 72
8 2.002
Inf
0.546
0.403
0.0
0.546
0.01
-0.000401
1.0
0.595
Inf
0.597
0.638
0.0
0.597
0.01
-0.327
1.0
0.636
BT-20 Trametinib 1 72
sigmoid
sigmoid
BT20 trametinib 0 1 72
8 2.016
14.3
0.54
0.225
0.135
0.458
0.534
0.989
1.3e-06
NA
Inf
0.59
0.791
0.0955
0.534
0.545
0.989
1.43e-06
NA
BT-20 WYE-125132 1 72
sigmoid
sigmoid
BT20 WYE-132 0 1 72
8 2.067
0.0893
0.289
0.402
0.0435
0.256
1.0
0.987
2.28e-06
NA
0.154
0.403
0.647
0.0353
0.375
0.941
0.985
3.56e-06
NA
BT-20 Buparlisib 1 72
sigmoid
sigmoid
BT20 buparlisib 0 1 72
8 2.131
0.598
-0.394
0.285
1.19
-0.763
1.35
0.992
4.68e-07
NA
0.663
0.0784
0.766
0.663
0.0
1.49
0.981
7.06e-06
NA
BT-20 MK2206 1 72
sigmoid
sigmoid
BT20 MK-2206 0 1 72
8 2.089
Inf
0.732
0.102
4.16
0.529
0.345
0.671
0.0357
NA
Inf
0.741
0.898
4.14
0.538
0.337
0.676
0.034
NA
BT-20 PIK-93 1 72
sigmoid
sigmoid
BT20 PIK-93 0 1 72
8 2.025
2.65
0.406
0.0864
6.54
-1.0
1.22
0.993
3.89e-07
NA
3.15
0.49
0.92
3.15
0.0
1.31
0.989
1.33e-06
NA
BT-20 Sirolimus 1 72
flat
flat
BT20 rapamycin 0 1 72
8 2.100
Inf
0.568
0.431
0.0
0.568
0.01
-9.89
1.0
0.568
Inf
0.6
0.601
0.0
0.6
0.01
-13.0
1.0
0.6
BT-20 Torin1 1 72
sigmoid
sigmoid
BT20 Torin1 0 1 72
8 2.022
0.0383
-0.105
0.566
0.0658
-0.179
0.565
0.991
7.45e-07
NA
0.0591
0.197
0.536
0.0286
0.182
0.624
0.994
2.54e-07
NA
BT-20 Torin2 1 72
sigmoid
sigmoid
BT20 Torin2 0 1 72
8 2.018
0.0185
-0.739
0.803
0.158
-1.0
0.511
0.986
2.9e-06
NA
0.0245
0.0164
0.415
0.0245
0.0
0.616
0.99
1.06e-06
NA
BT-20 AZD8055 1 72
sigmoid
sigmoid
BT20 AZD8055 0 1 72
8 2.117
0.0548
0.243
0.465
0.0266
0.213
0.768
0.984
4.08e-06
NA
0.0937
0.365
0.589
0.0198
0.335
0.713
0.982
5.4e-06
NA
BT-20 Omipalisib 1 72
sigmoid
sigmoid
BT20 omipalisib 0 1 72
8 2.078
0.00617
-0.729
0.985
0.0283
-0.739
0.596
0.97
2.83e-05
NA
0.00781
0.0157
0.306
0.00685
0.0597
0.96
0.988
1.57e-06
NA
BT-20 BX-912 1 72
flat
flat
BT20 BX-912 0 1 72
8 2.193
Inf
0.858
0.0928
0.0
0.858
0.01
0.25
0.422
0.903
Inf
0.851
0.901
0.0
0.851
0.01
0.243
0.433
0.897
BT-20 AZD-6482 1 72
sigmoid
sigmoid
BT20 AZD6482 0 1 72
8 2.043
1.34
0.182
0.173
3.83
-0.782
0.893
0.982
5.6e-06
NA
1.65
0.342
0.845
1.65
0.0
0.977
0.972
2.09e-05
NA
BT-20 KIN001-244 1 72
flat
flat
BT20 KIN001-244 0 1 72
8 2.125
Inf
0.911
0.0401
0.0
0.911
0.01
-0.00641
1.0
0.957
Inf
0.908
0.958
0.0
0.908
0.01
-0.00745
1.0
0.955
BT-20 Alpelisib 1 72
sigmoid
sigmoid
BT20 alpelisib 0 1 72
8 2.077
1.14
0.046
0.196
3.52
-1.0
0.977
0.966
4.1e-05
NA
1.32
0.26
0.825
1.32
0.0
1.13
0.942
0.000194
NA
BT-20 Dactolisib 1 72
sigmoid
sigmoid
BT20 dactolisib 0 1 72
8 2.055
0.0223
-0.205
0.652
0.0609
-0.33
0.505
0.979
9.18e-06
NA
0.0305
0.15
0.475
0.0171
0.153
0.631
0.979
9.75e-06
NA
BT-20 Pictilisib 1 72
sigmoid
sigmoid
BT20 pictilisib 0 1 72
8 2.085
1.25
0.163
0.177
5.0
-1.0
0.791
0.994
1.75e-07
NA
1.52
0.323
0.838
1.52
0.0
0.865
0.989
1.22e-06
NA
BT-20 CAL-101 1 72
flat
flat
BT20 idelalisib 0 1 72
8 2.112
Inf
0.869
0.0546
0.0
0.869
0.01
0.0807
0.777
0.938
Inf
0.867
0.943
0.0
0.867
0.01
0.0778
0.784
0.936
BT-20 AS605240 1 72
sigmoid
sigmoid
BT20 AS-605240 0 1 72
8 2.142
Inf
0.817
0.0993
3.91
0.634
0.244
0.861
0.00271
NA
Inf
0.814
0.897
3.87
0.629
0.237
0.854
0.00311
NA
BT-20 GDC-0980 1 72
sigmoid
sigmoid
BT20 apitolisib 0 1 72
8 2.001
0.0935
-0.289
0.498
0.128
-0.251
1.29
0.994
2.71e-07
NA
0.113
0.126
0.62
0.0885
0.151
1.48
0.996
7.34e-08
NA
BT-549 AS605240 1 72
sigmoid
sigmoid
BT549 AS-605240 0 1 72
8 1.804
Inf
0.893
0.0436
4.49
0.778
0.375
0.862
0.00261
NA
Inf
0.905
0.961
4.52
0.804
0.371
0.861
0.00267
NA
BT-20 ZSTK474 1 72
sigmoid
sigmoid
BT20 ZSTK474 0 1 72
8 1.940
0.788
0.0217
0.122
0.819
-0.0395
1.99
0.957
7.76e-05
NA
0.942
0.272
0.913
0.677
0.249
2.09
0.934
0.000293
NA
  • Page 1 of 18
  • 1 to 25 of 432 records