Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
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BT-549 | Dactolisib | 3 | 72 | sigmoid | sigmoid | BT549 dactolisib 0 3 72 | 8 | 1.801 | 0.0058 | -0.00929 | 0.751 | 0.00579 | 0.000747 | 0.866 | 0.994 | 2.41e-07 | NA | 0.011 | 0.282 | 0.442 | 0.00425 | 0.29 | 0.909 | 0.995 | 1.54e-07 | NA |
HCC38 | AZD8055 | 3 | 72 | sigmoid | sigmoid | HCC38 AZD8055 0 3 72 | 8 | 1.417 | 0.0464 | 0.0327 | 0.53 | 0.0463 | 0.000983 | 1.04 | 0.997 | 4.27e-08 | NA | 0.157 | 0.392 | 0.658 | 0.041 | 0.372 | 1.02 | 0.996 | 5.78e-08 | NA |
HCC38 | Dactolisib | 2 | 72 | sigmoid | sigmoid | HCC38 dactolisib 0 2 72 | 8 | 2.120 | 0.0118 | -0.0557 | 0.668 | 0.0118 | -0.00134 | 0.785 | 0.98 | 7.61e-06 | NA | 0.0145 | 0.204 | 0.447 | 0.00701 | 0.245 | 0.927 | 0.988 | 1.88e-06 | NA |
BT-549 | ZSTK474 | 1 | 72 | sigmoid | sigmoid | BT549 ZSTK474 0 1 72 | 8 | 1.861 | 0.58 | 0.213 | 0.256 | 0.583 | -0.00205 | 0.771 | 0.992 | 5.43e-07 | NA | 1.12 | 0.394 | 0.788 | 0.428 | 0.261 | 0.767 | 0.989 | 1.49e-06 | NA |
HCC38 | Trametinib | 2 | 72 | sigmoid | sigmoid | HCC38 trametinib 0 2 72 | 8 | 2.133 | 0.219 | 0.267 | 0.389 | 0.222 | -0.00324 | 0.424 | 0.987 | 2.39e-06 | NA | 0.391 | 0.377 | 0.644 | 0.127 | 0.183 | 0.404 | 0.988 | 1.91e-06 | NA |
HCC70 | BX-912 | 2 | 72 | sigmoid | sigmoid | HCC70 BX-912 0 2 72 | 8 | 1.693 | 1.25 | 0.00257 | 0.0619 | 1.25 | -0.00649 | 5.0 | 0.971 | 2.55e-05 | NA | 1.44 | 0.311 | 0.961 | 1.2 | 0.306 | 5.0 | 0.956 | 8.35e-05 | NA |
Hs 578T | Dactolisib | 2 | sigmoid | sigmoid | Hs578T dactolisib 2 | 8 | 2.509 | 0.0128 | -0.0617 | 0.655 | 0.0126 | 0.00741 | 0.79 | 0.974 | 1.78e-05 | NA | 0.0105 | 0.15 | 0.405 | 0.00638 | 0.203 | 1.04 | 0.985 | 3.67e-06 | NA | |
BT-549 | GDC-0980 | 2 | 72 | sigmoid | sigmoid | BT549 apitolisib 0 2 72 | 8 | 1.939 | 0.189 | 0.0264 | 0.357 | 0.193 | -0.011 | 1.04 | 0.997 | 2.98e-08 | NA | 0.278 | 0.274 | 0.71 | 0.142 | 0.257 | 1.07 | 0.997 | 3.64e-08 | NA |
Hs 578T | AS605240 | 2 | sigmoid | sigmoid | Hs578T AS-605240 2 | 8 | 2.547 | 1.89 | 0.43 | 0.194 | 1.81 | 0.011 | 0.541 | 0.988 | 1.81e-06 | NA | 1.6 | 0.426 | 0.784 | 0.971 | 0.117 | 0.532 | 0.983 | 4.67e-06 | NA | |
HCC38 | WYE-125132 | 3 | 72 | sigmoid | sigmoid | HCC38 WYE-132 0 3 72 | 8 | 1.449 | 0.0494 | -0.0216 | 0.518 | 0.0504 | -0.0117 | 1.18 | 0.998 | 9.69e-09 | NA | 0.128 | 0.355 | 0.662 | 0.0441 | 0.361 | 1.2 | 0.998 | 9.53e-09 | NA |
Hs 578T | Dactolisib | 1 | sigmoid | sigmoid | Hs578T dactolisib 1 | 8 | 2.047 | 0.00952 | -0.0606 | 0.691 | 0.00928 | 0.0117 | 0.91 | 0.977 | 1.27e-05 | NA | 0.0124 | 0.213 | 0.443 | 0.00621 | 0.259 | 1.06 | 0.985 | 3.61e-06 | NA | |
HCC38 | Torin1 | 1 | 72 | sigmoid | sigmoid | HCC38 Torin1 0 1 72 | 8 | 1.688 | 0.0287 | -0.0113 | 0.569 | 0.0278 | 0.013 | 0.843 | 0.993 | 4.14e-07 | NA | 0.0653 | 0.304 | 0.585 | 0.0204 | 0.325 | 0.9 | 0.992 | 4.53e-07 | NA |
BT-549 | GDC-0980 | 3 | 72 | sigmoid | sigmoid | BT549 apitolisib 0 3 72 | 8 | 1.802 | 0.162 | 0.0283 | 0.377 | 0.158 | 0.0179 | 1.2 | 0.994 | 2.53e-07 | NA | 0.268 | 0.302 | 0.709 | 0.128 | 0.294 | 1.2 | 0.992 | 4.85e-07 | NA |
HCC38 | Trametinib | 1 | 72 | sigmoid | sigmoid | HCC38 trametinib 0 1 72 | 8 | 1.733 | 0.162 | 0.196 | 0.407 | 0.173 | -0.0184 | 0.559 | 0.948 | 0.000139 | NA | 0.568 | 0.41 | 0.686 | 0.161 | 0.234 | 0.501 | 0.947 | 0.000151 | NA |
HCC38 | Dactolisib | 1 | 72 | sigmoid | sigmoid | HCC38 dactolisib 0 1 72 | 8 | 1.821 | 0.0109 | -0.0403 | 0.672 | 0.0104 | 0.0212 | 0.892 | 0.985 | 3.44e-06 | NA | 0.0194 | 0.263 | 0.492 | 0.00757 | 0.301 | 0.975 | 0.988 | 1.65e-06 | NA |
BT-549 | PI103 | 3 | 72 | sigmoid | sigmoid | BT549 PI-103 0 3 72 | 8 | 1.758 | 0.16 | 0.00249 | 0.391 | 0.166 | -0.0225 | 1.12 | 0.989 | 1.19e-06 | NA | 0.279 | 0.297 | 0.704 | 0.134 | 0.28 | 1.12 | 0.985 | 3.23e-06 | NA |
HCC70 | AZD-6482 | 2 | 72 | sigmoid | sigmoid | HCC70 AZD6482 0 2 72 | 8 | 1.772 | 0.267 | 0.256 | 0.366 | 0.237 | 0.0255 | 0.43 | 0.987 | 2.27e-06 | NA | 1.16 | 0.438 | 0.706 | 0.133 | 0.306 | 0.437 | 0.986 | 3.03e-06 | NA |
BT-549 | PI103 | 2 | 72 | sigmoid | sigmoid | BT549 PI-103 0 2 72 | 8 | 1.893 | 0.218 | 0.0201 | 0.344 | 0.229 | -0.0262 | 1.08 | 0.997 | 2.55e-08 | NA | 0.326 | 0.28 | 0.725 | 0.169 | 0.261 | 1.13 | 0.996 | 6.2e-08 | NA |
BT-20 | PI103 | 1 | 72 | sigmoid | sigmoid | BT20 PI-103 0 1 72 | 8 | 1.924 | 0.646 | -0.0114 | 0.16 | 0.659 | -0.0268 | 2.6 | 0.978 | 1.1e-05 | NA | 0.753 | 0.258 | 0.883 | 0.579 | 0.252 | 2.68 | 0.964 | 4.79e-05 | NA |
BT-20 | PI103 | 3 | 72 | sigmoid | sigmoid | BT20 PI-103 0 3 72 | 8 | 2.496 | 0.373 | 0.0139 | 0.282 | 0.387 | -0.0286 | 1.52 | 0.994 | 1.99e-07 | NA | 0.359 | 0.183 | 0.735 | 0.279 | 0.162 | 1.56 | 0.988 | 1.71e-06 | NA |
Hs 578T | Torin1 | 1 | sigmoid | sigmoid | Hs578T Torin1 1 | 8 | 1.956 | 0.0217 | 0.0183 | 0.598 | 0.0203 | 0.0286 | 0.911 | 0.994 | 1.81e-07 | NA | 0.0321 | 0.267 | 0.524 | 0.0141 | 0.28 | 0.995 | 0.996 | 8.78e-08 | NA | |
HCC70 | PI103 | 3 | 72 | sigmoid | sigmoid | HCC70 PI-103 0 3 72 | 8 | 2.446 | 1.51 | 0.227 | 0.0983 | 1.57 | -0.0288 | 1.54 | 0.986 | 2.66e-06 | NA | 1.48 | 0.303 | 0.906 | 1.15 | 0.168 | 1.59 | 0.976 | 1.42e-05 | NA |
HCC38 | GDC-0980 | 1 | 72 | sigmoid | sigmoid | HCC38 apitolisib 0 1 72 | 8 | 1.777 | 0.317 | 0.114 | 0.305 | 0.295 | 0.0315 | 0.91 | 0.99 | 9.47e-07 | NA | 0.623 | 0.354 | 0.761 | 0.219 | 0.315 | 0.951 | 0.989 | 1.26e-06 | NA |
Hs 578T | PIK-93 | 3 | sigmoid | sigmoid | Hs578T PIK-93 3 | 8 | 2.816 | 2.36 | 0.412 | 0.0884 | 2.23 | 0.033 | 1.2 | 0.994 | 1.87e-07 | NA | 1.89 | 0.375 | 0.897 | 1.42 | 0.149 | 1.24 | 0.991 | 8.33e-07 | NA | |
Hs 578T | Trametinib | 2 | sigmoid | sigmoid | Hs578T trametinib 2 | 8 | 2.483 | 0.00633 | 0.074 | 0.701 | 0.00558 | 0.0362 | 0.593 | 0.998 | 1.32e-08 | NA | 0.0058 | 0.214 | 0.361 | 0.00257 | 0.193 | 0.602 | 0.998 | 3.66e-09 | NA |