Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
BT-549 CAL-101 2 72
sigmoid
sigmoid
BT549 idelalisib 0 2 72
 8 1.975
Inf
0.792
0.0561
4.65
0.526
0.693
0.933
0.000307
NA
43.0
0.805
0.946
43.0
0.0
0.548
0.932
0.000314
NA
BT-549 Buparlisib 3 72
sigmoid
sigmoid
BT549 buparlisib 0 3 72
 8 1.795
0.602
-0.351
0.295
1.64
-1.0
1.09
0.983
4.52e-06
NA
0.804
0.132
0.777
0.804
0.0
1.26
0.968
3.41e-05
NA
BT-20 ZSTK474 3 72
sigmoid
sigmoid
BT20 ZSTK474 0 3 72
 8 2.609
0.457
-0.00222
0.296
0.783
-0.31
0.895
0.982
5.76e-06
NA
0.422
0.163
0.702
0.422
0.0
0.82
0.971
2.52e-05
NA
BT-20 PIK-93 2 72
sigmoid
sigmoid
BT20 PIK-93 0 2 72
 8 1.798
0.792
0.155
0.286
14.1
-1.0
0.382
0.81
0.00687
NA
2.8
0.373
0.764
2.8
0.0
0.344
0.77
0.0121
NA
BT-549 AZD-6482 2 72
sigmoid
sigmoid
BT549 AZD6482 0 2 72
 8 1.973
9.15
0.635
0.112
120.0
-1.0
0.426
0.951
0.000115
NA
19.4
0.672
0.895
19.4
0.0
0.437
0.946
0.000154
NA
BT-20 Torin2 1 72
sigmoid
sigmoid
BT20 Torin2 0 1 72
 8 2.018
0.0185
-0.739
0.803
0.158
-1.0
0.511
0.986
2.9e-06
NA
0.0245
0.0164
0.415
0.0245
0.0
0.616
0.99
1.06e-06
NA
BT-20 Trametinib 2 72
sigmoid
sigmoid
BT20 trametinib 0 2 72
 8 1.723
0.761
0.303
0.289
11.1
-0.768
0.347
0.965
4.13e-05
NA
2.56
0.478
0.77
2.56
0.0
0.362
0.957
8.16e-05
NA
BT-20 Buparlisib 1 72
sigmoid
sigmoid
BT20 buparlisib 0 1 72
 8 2.131
0.598
-0.394
0.285
1.19
-0.763
1.35
0.992
4.68e-07
NA
0.663
0.0784
0.766
0.663
0.0
1.49
0.981
7.06e-06
NA
BT-20 AZD-6482 2 72
sigmoid
sigmoid
BT20 AZD6482 0 2 72
 8 1.645
0.581
0.0253
0.303
3.86
-1.0
0.58
0.904
0.000884
NA
1.34
0.333
0.772
1.34
0.0
0.582
0.864
0.0025
NA
BT-20 PIK-93 1 72
sigmoid
sigmoid
BT20 PIK-93 0 1 72
 8 2.025
2.65
0.406
0.0864
6.54
-1.0
1.22
0.993
3.89e-07
NA
3.15
0.49
0.92
3.15
0.0
1.31
0.989
1.33e-06
NA
BT-549 Buparlisib 1 72
sigmoid
sigmoid
BT549 buparlisib 0 1 72
 8 1.837
0.729
-0.325
0.253
1.83
-1.0
1.19
0.994
2.4e-07
NA
0.926
0.136
0.807
0.926
0.0
1.37
0.987
2.46e-06
NA
BT-20 PIK-93 3 72
sigmoid
sigmoid
BT20 PIK-93 0 3 72
 8 2.532
2.65
0.419
0.097
7.54
-1.0
1.05
0.982
5.47e-06
NA
2.5
0.42
0.892
2.5
0.0
1.17
0.971
2.45e-05
NA
BT-20 Buparlisib 2 72
sigmoid
sigmoid
BT20 buparlisib 0 2 72
 8 1.743
0.334
-0.45
0.391
0.844
-0.82
1.05
0.972
2.21e-05
NA
0.487
0.105
0.718
0.487
0.0
1.12
0.948
0.000142
NA
BT-20 Buparlisib 3 72
sigmoid
sigmoid
BT20 buparlisib 0 3 72
 8 2.529
0.629
-0.303
0.26
1.06
-0.565
1.46
0.994
2.13e-07
NA
0.603
0.0696
0.764
0.603
0.0
1.52
0.984
4.36e-06
NA
BT-20 AZD-6482 1 72
sigmoid
sigmoid
BT20 AZD6482 0 1 72
 8 2.043
1.34
0.182
0.173
3.83
-0.782
0.893
0.982
5.6e-06
NA
1.65
0.342
0.845
1.65
0.0
0.977
0.972
2.09e-05
NA
BT-20 MK2206 3 72
sigmoid
sigmoid
BT20 MK-2206 0 3 72
 8 2.449
1.73
0.252
0.12
3.23
-0.504
1.11
0.988
1.77e-06
NA
1.69
0.318
0.877
1.69
0.0
1.18
0.979
9.03e-06
NA
BT-20 Pictilisib 2 72
sigmoid
sigmoid
BT20 pictilisib 0 2 72
 8 1.746
0.308
-0.0521
0.379
2.35
-1.0
0.54
0.791
0.00908
NA
0.634
0.272
0.712
0.634
0.0
0.6
0.716
0.0229
NA
BT-20 Alpelisib 1 72
sigmoid
sigmoid
BT20 alpelisib 0 1 72
 8 2.077
1.14
0.046
0.196
3.52
-1.0
0.977
0.966
4.1e-05
NA
1.32
0.26
0.825
1.32
0.0
1.13
0.942
0.000194
NA
BT-20 Alpelisib 2 72
sigmoid
sigmoid
BT20 alpelisib 0 2 72
 8 1.692
0.253
-0.0994
0.405
2.25
-1.0
0.503
0.835
0.00451
NA
0.612
0.259
0.698
0.612
0.0
0.507
0.764
0.0131
NA
BT-20 Alpelisib 3 72
sigmoid
sigmoid
BT20 alpelisib 0 3 72
 8 2.541
1.21
0.199
0.21
5.83
-1.0
0.697
0.881
0.00167
NA
1.12
0.272
0.775
1.12
0.0
0.764
0.791
0.00916
NA
BT-20 MK2206 2 72
sigmoid
sigmoid
BT20 MK-2206 0 2 72
 8 1.739
0.823
0.0896
0.246
4.34
-1.0
0.661
0.965
4.36e-05
NA
1.47
0.348
0.806
1.47
0.0
0.715
0.947
0.000145
NA
BT-20 Pictilisib 1 72
sigmoid
sigmoid
BT20 pictilisib 0 1 72
 8 2.085
1.25
0.163
0.177
5.0
-1.0
0.791
0.994
1.75e-07
NA
1.52
0.323
0.838
1.52
0.0
0.865
0.989
1.22e-06
NA
BT-20 AZD-6482 3 72
sigmoid
sigmoid
BT20 AZD6482 0 3 72
 8 2.601
1.68
0.3
0.173
8.38
-1.0
0.685
0.959
6.72e-05
NA
1.5
0.326
0.805
1.5
0.0
0.733
0.925
0.000414
NA
BT-549 Pictilisib 2 72
sigmoid
sigmoid
BT549 pictilisib 0 2 72
 8 1.960
1.84
0.365
0.166
11.5
-1.0
0.599
0.943
0.000187
NA
2.82
0.473
0.851
2.82
0.0
0.647
0.924
0.000432
NA
BT-549 CAL-101 3 72
sigmoid
sigmoid
BT549 idelalisib 0 3 72
 8 1.770
43.0
0.79
0.0687
320.0
-0.664
0.421
0.862
0.00261
NA
118.0
0.822
0.941
118.0
0.0
0.425
0.854
0.00309
NA
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