Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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  • Page 1 of 18
  • 1 to 25 of 432 records
Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
BT-549 Alpelisib 3 72
flat
flat
BT549 alpelisib 0 3 72
8 1.743
Inf
0.817
0.068
0.0
0.817
0.01
-0.0192
1.0
0.915
Inf
0.846
0.942
0.0
0.846
0.01
-0.0162
1.0
0.928
BT-20 XL147 1 72
flat
flat
BT20 pilaralisib 0 1 72
8 2.128
Inf
0.815
0.048
0.0
0.815
0.01
0.411
0.205
0.939
Inf
0.813
0.95
0.0
0.813
0.01
0.383
0.234
0.937
BT-549 AS605240 2 72
flat
flat
BT549 AS-605240 0 2 72
8 1.961
Inf
0.91
0.0479
0.0
0.91
0.01
0.414
0.201
0.949
Inf
0.914
0.954
0.0
0.914
0.01
0.418
0.197
0.951
BT-20 XL147 3 72
flat
flat
BT20 pilaralisib 0 3 72
8 2.647
Inf
0.755
0.102
0.0
0.755
0.01
0.0679
0.81
0.885
Inf
0.708
0.871
0.0
0.708
0.01
0.0505
0.856
0.857
BT-549 Alpelisib 1 72
flat
flat
BT549 alpelisib 0 1 72
8 1.822
Inf
0.747
0.0781
0.0
0.747
0.01
0.439
0.176
0.914
Inf
0.782
0.931
0.0
0.782
0.01
0.415
0.2
0.925
BT-20 KIN001-244 3 72
flat
flat
BT20 KIN001-244 0 3 72
8 2.608
Inf
0.841
0.062
0.0
0.841
0.01
0.489
0.133
0.935
Inf
0.805
0.922
0.0
0.805
0.01
0.475
0.145
0.919
BT-20 TGX221 3 72
flat
flat
BT20 TGX-221 0 3 72
8 2.469
Inf
1.01
0.0147
0.0
1.01
0.01
-0.0563
1.0
0.982
Inf
1.01
0.983
0.0
1.01
0.01
-0.0552
1.0
0.979
BT-20 TGX221 1 72
flat
flat
BT20 TGX-221 0 1 72
8 1.988
Inf
1.02
-0.00357
0.0
1.02
0.01
-0.00762
1.0
1.0
Inf
1.02
1.0
0.0
1.02
0.01
-0.00881
1.0
1.0
BT-20 XL147 2 72
flat
flat
BT20 pilaralisib 0 2 72
8 1.784
Inf
0.759
0.073
0.0
0.759
0.01
-0.0058
1.0
0.907
Inf
0.796
0.937
0.0
0.796
0.01
-0.00637
1.0
0.92
BT-20 TGX221 2 72
flat
flat
BT20 TGX-221 0 2 72
8 1.656
Inf
1.0
0.0477
0.0
1.0
0.01
-0.101
1.0
0.946
Inf
1.0
0.961
0.0
1.0
0.01
-0.101
1.0
0.956
BT-20 Sirolimus 2 72
flat
flat
BT20 rapamycin 0 2 72
8 1.952
Inf
0.421
0.579
0.0
0.421
0.01
NA
NA
0.421
Inf
0.513
0.513
0.0
0.513
0.01
NA
NA
0.513
BT-20 Sirolimus 1 72
flat
flat
BT20 rapamycin 0 1 72
8 2.100
Inf
0.568
0.431
0.0
0.568
0.01
-9.89
1.0
0.568
Inf
0.6
0.601
0.0
0.6
0.01
-13.0
1.0
0.6
BT-20 Everolimus 3 72
flat
flat
BT20 everolimus 0 3 72
8 2.422
Inf
0.475
0.456
0.0
0.475
0.01
0.602
0.0632
0.543
Inf
0.478
0.534
0.0
0.478
0.01
0.561
0.0844
0.534
BT-20 Everolimus 2 72
flat
flat
BT20 everolimus 0 2 72
8 1.785
Inf
0.426
0.574
0.0
0.426
0.01
NA
NA
0.426
Inf
0.547
0.547
0.0
0.547
0.01
NA
NA
0.547
BT-20 BX-912 1 72
flat
flat
BT20 BX-912 0 1 72
8 2.193
Inf
0.858
0.0928
0.0
0.858
0.01
0.25
0.422
0.903
Inf
0.851
0.901
0.0
0.851
0.01
0.243
0.433
0.897
BT-20 BX-912 2 72
flat
flat
BT20 BX-912 0 2 72
8 1.873
Inf
0.683
0.213
0.0
0.683
0.01
0.118
0.686
0.777
Inf
0.724
0.81
0.0
0.724
0.01
0.111
0.702
0.802
BT-20 BX-912 3 72
flat
flat
BT20 BX-912 0 3 72
8 2.619
Inf
0.904
0.0795
0.0
0.904
0.01
0.000173
0.999
0.918
Inf
0.879
0.9
0.0
0.879
0.01
0.00619
0.982
0.896
BT-20 Everolimus 1 72
flat
flat
BT20 everolimus 0 1 72
8 2.002
Inf
0.546
0.403
0.0
0.546
0.01
-0.000401
1.0
0.595
Inf
0.597
0.638
0.0
0.597
0.01
-0.327
1.0
0.636
BT-20 Sirolimus 3 72
flat
flat
BT20 rapamycin 0 3 72
8 2.661
Inf
0.54
0.46
0.0
0.54
0.01
NA
NA
0.54
Inf
0.499
0.499
0.0
0.499
0.01
NA
NA
0.499
BT-20 KIN001-244 1 72
flat
flat
BT20 KIN001-244 0 1 72
8 2.125
Inf
0.911
0.0401
0.0
0.911
0.01
-0.00641
1.0
0.957
Inf
0.908
0.958
0.0
0.908
0.01
-0.00745
1.0
0.955
BT-20 CAL-101 1 72
flat
flat
BT20 idelalisib 0 1 72
8 2.112
Inf
0.869
0.0546
0.0
0.869
0.01
0.0807
0.777
0.938
Inf
0.867
0.943
0.0
0.867
0.01
0.0778
0.784
0.936
BT-20 CAL-101 2 72
flat
flat
BT20 idelalisib 0 2 72
8 1.768
Inf
0.818
0.0943
0.0
0.818
0.01
0.226
0.463
0.898
Inf
0.845
0.918
0.0
0.845
0.01
0.222
0.471
0.912
BT-20 CAL-101 3 72
flat
flat
BT20 idelalisib 0 3 72
8 2.589
Inf
0.916
0.0535
0.0
0.916
0.01
0.0547
0.845
0.944
Inf
0.894
0.932
0.0
0.894
0.01
0.0506
0.856
0.929
BT-549 Everolimus 3 72
sigmoid
flat
BT549 everolimus 0 3 72
8 1.587
59.5
0.533
0.425
1e-05
0.395
0.1
0.702
0.0264
NA
Inf
0.656
0.685
0.0
0.656
0.01
0.48
0.141
0.685
BT-549 Everolimus 2 72
flat
flat
BT549 everolimus 0 2 72
8 1.909
Inf
0.566
0.407
0.0
0.566
0.01
-0.646
1.0
0.594
Inf
0.627
0.648
0.0
0.627
0.01
-1.01
1.0
0.649
  • Page 1 of 18
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