Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
BT-20	AS605240	1	72	sigmoid	sigmoid	BT20 AS-605240 0 1 72	8	2.142	Inf	0.817	0.0993	3.91	0.634	0.244	0.861	0.00271	NA	Inf	0.814	0.897	3.87	0.629	0.237	0.854	0.00311	NA
BT-20	AS605240	2	72	sigmoid	sigmoid	BT20 AS-605240 0 2 72	8	1.846	4509270.0	0.729	0.203	320.0	0.31	0.101	0.845	0.00373	NA	4.4e+12	0.764	0.821	56.5	0.46	0.101	0.843	0.00388	NA
BT-20	AS605240	3	72	sigmoid	sigmoid	BT20 AS-605240 0 3 72	8	2.607	Inf	0.845	0.0823	4.13	0.662	0.292	0.729	0.0199	NA	Inf	0.81	0.897	3.97	0.589	0.284	0.712	0.0239	NA
BT-20	AZD-6482	1	72	sigmoid	sigmoid	BT20 AZD6482 0 1 72	8	2.043	1.34	0.182	0.173	3.83	-0.782	0.893	0.982	5.6e-06	NA	1.65	0.342	0.845	1.65	0.0	0.977	0.972	2.09e-05	NA
BT-20	AZD-6482	2	72	sigmoid	sigmoid	BT20 AZD6482 0 2 72	8	1.645	0.581	0.0253	0.303	3.86	-1.0	0.58	0.904	0.000884	NA	1.34	0.333	0.772	1.34	0.0	0.582	0.864	0.0025	NA
BT-20	AZD-6482	3	72	sigmoid	sigmoid	BT20 AZD6482 0 3 72	8	2.601	1.68	0.3	0.173	8.38	-1.0	0.685	0.959	6.72e-05	NA	1.5	0.326	0.805	1.5	0.0	0.733	0.925	0.000414	NA
BT-20	AZD8055	1	72	sigmoid	sigmoid	BT20 AZD8055 0 1 72	8	2.117	0.0548	0.243	0.465	0.0266	0.213	0.768	0.984	4.08e-06	NA	0.0937	0.365	0.589	0.0198	0.335	0.713	0.982	5.4e-06	NA
BT-20	AZD8055	2	72	sigmoid	sigmoid	BT20 AZD8055 0 2 72	8	1.951	0.00909	0.155	0.651	0.00651	0.115	0.785	0.936	0.000258	NA	0.0185	0.343	0.477	0.00469	0.311	0.706	0.934	0.000289	NA
BT-20	AZD8055	3	72	sigmoid	sigmoid	BT20 AZD8055 0 3 72	8	2.694	0.0351	0.345	0.472	0.0116	0.313	0.89	0.934	0.000286	NA	0.0291	0.343	0.506	0.00813	0.306	0.743	0.922	0.000471	NA
BT-20	Dactolisib	1	72	sigmoid	sigmoid	BT20 dactolisib 0 1 72	8	2.055	0.0223	-0.205	0.652	0.0609	-0.33	0.505	0.979	9.18e-06	NA	0.0305	0.15	0.475	0.0171	0.153	0.631	0.979	9.75e-06	NA
BT-20	Dactolisib	2	72	sigmoid	sigmoid	BT20 dactolisib 0 2 72	8	1.727	0.00497	-0.212	0.896	0.00652	-0.186	1.17	0.995	1.45e-07	NA	0.00801	0.2	0.382	0.00505	0.211	1.19	0.994	2.07e-07	NA
BT-20	Dactolisib	3	72	sigmoid	sigmoid	BT20 dactolisib 0 3 72	8	2.420	0.0111	0.024	0.639	0.00921	0.0987	1.17	0.982	6.27e-06	NA	0.0106	0.198	0.427	0.00645	0.241	1.32	0.99	9.14e-07	NA
BT-20	Buparlisib	1	72	sigmoid	sigmoid	BT20 buparlisib 0 1 72	8	2.131	0.598	-0.394	0.285	1.19	-0.763	1.35	0.992	4.68e-07	NA	0.663	0.0784	0.766	0.663	0.0	1.49	0.981	7.06e-06	NA
BT-20	Buparlisib	2	72	sigmoid	sigmoid	BT20 buparlisib 0 2 72	8	1.743	0.334	-0.45	0.391	0.844	-0.82	1.05	0.972	2.21e-05	NA	0.487	0.105	0.718	0.487	0.0	1.12	0.948	0.000142	NA
BT-20	Buparlisib	3	72	sigmoid	sigmoid	BT20 buparlisib 0 3 72	8	2.529	0.629	-0.303	0.26	1.06	-0.565	1.46	0.994	2.13e-07	NA	0.603	0.0696	0.764	0.603	0.0	1.52	0.984	4.36e-06	NA
BT-20	BX-912	1	72	flat	flat	BT20 BX-912 0 1 72	8	2.193	Inf	0.858	0.0928	0.0	0.858	0.01	0.25	0.422	0.903	Inf	0.851	0.901	0.0	0.851	0.01	0.243	0.433	0.897
BT-20	BX-912	2	72	flat	flat	BT20 BX-912 0 2 72	8	1.873	Inf	0.683	0.213	0.0	0.683	0.01	0.118	0.686	0.777	Inf	0.724	0.81	0.0	0.724	0.01	0.111	0.702	0.802
BT-20	BX-912	3	72	flat	flat	BT20 BX-912 0 3 72	8	2.619	Inf	0.904	0.0795	0.0	0.904	0.01	0.000173	0.999	0.918	Inf	0.879	0.9	0.0	0.879	0.01	0.00619	0.982	0.896
BT-20	Alpelisib	1	72	sigmoid	sigmoid	BT20 alpelisib 0 1 72	8	2.077	1.14	0.046	0.196	3.52	-1.0	0.977	0.966	4.1e-05	NA	1.32	0.26	0.825	1.32	0.0	1.13	0.942	0.000194	NA
BT-20	Alpelisib	2	72	sigmoid	sigmoid	BT20 alpelisib 0 2 72	8	1.692	0.253	-0.0994	0.405	2.25	-1.0	0.503	0.835	0.00451	NA	0.612	0.259	0.698	0.612	0.0	0.507	0.764	0.0131	NA
BT-20	Alpelisib	3	72	sigmoid	sigmoid	BT20 alpelisib 0 3 72	8	2.541	1.21	0.199	0.21	5.83	-1.0	0.697	0.881	0.00167	NA	1.12	0.272	0.775	1.12	0.0	0.764	0.791	0.00916	NA
BT-20	CAL-101	1	72	flat	flat	BT20 idelalisib 0 1 72	8	2.112	Inf	0.869	0.0546	0.0	0.869	0.01	0.0807	0.777	0.938	Inf	0.867	0.943	0.0	0.867	0.01	0.0778	0.784	0.936
BT-20	CAL-101	2	72	flat	flat	BT20 idelalisib 0 2 72	8	1.768	Inf	0.818	0.0943	0.0	0.818	0.01	0.226	0.463	0.898	Inf	0.845	0.918	0.0	0.845	0.01	0.222	0.471	0.912
BT-20	CAL-101	3	72	flat	flat	BT20 idelalisib 0 3 72	8	2.589	Inf	0.916	0.0535	0.0	0.916	0.01	0.0547	0.845	0.944	Inf	0.894	0.932	0.0	0.894	0.01	0.0506	0.856	0.929
BT-20	Everolimus	1	72	flat	flat	BT20 everolimus 0 1 72	8	2.002	Inf	0.546	0.403	0.0	0.546	0.01	-0.000401	1.0	0.595	Inf	0.597	0.638	0.0	0.597	0.01	-0.327	1.0	0.636

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)