Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
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HCC70 | PI103 | 1 | 72 | sigmoid | sigmoid | HCC70 PI-103 0 1 72 | 8 | 1.305 | 1.04 | -0.0102 | 0.104 | 1.14 | -0.107 | 2.26 | 0.957 | 7.9e-05 | NA | 1.83 | 0.399 | 0.938 | 1.08 | 0.349 | 2.28 | 0.949 | 0.000133 | NA |
HCC70 | ZSTK474 | 1 | 72 | sigmoid | sigmoid | HCC70 ZSTK474 0 1 72 | 8 | 1.332 | 0.167 | -0.265 | 0.366 | 0.201 | -0.206 | 1.85 | 0.975 | 1.56e-05 | NA | 0.289 | 0.264 | 0.782 | 0.182 | 0.299 | 1.96 | 0.971 | 2.35e-05 | NA |
HCC70 | AZD8055 | 1 | 72 | sigmoid | sigmoid | HCC70 AZD8055 0 1 72 | 8 | 1.339 | 0.0485 | 0.242 | 0.442 | 0.0243 | 0.26 | 1.06 | 0.976 | 1.32e-05 | NA | Inf | 0.529 | 0.721 | 0.0222 | 0.54 | 1.08 | 0.974 | 1.81e-05 | NA |
HCC38 | AS605240 | 3 | 72 | flat | flat | HCC38 AS-605240 0 3 72 | 8 | 1.343 | Inf | 0.958 | -0.0162 | 0.0 | 0.958 | 0.01 | -0.233 | 1.0 | 1.01 | Inf | 0.972 | 1.01 | 0.0 | 0.972 | 0.01 | -0.235 | 1.0 | 1.01 |
HCC70 | Torin1 | 1 | 72 | sigmoid | sigmoid | HCC70 Torin1 0 1 72 | 8 | 1.345 | 0.0472 | 0.15 | 0.487 | 0.0311 | 0.149 | 0.849 | 0.973 | 1.89e-05 | NA | 0.93 | 0.475 | 0.693 | 0.0276 | 0.475 | 0.854 | 0.973 | 2.05e-05 | NA |
HCC70 | KIN001-244 | 1 | 72 | flat | flat | HCC70 KIN001-244 0 1 72 | 8 | 1.350 | Inf | 0.889 | 0.00722 | 0.0 | 0.889 | 0.01 | 0.616 | 0.0568 | 0.988 | Inf | 0.926 | 0.995 | 0.0 | 0.926 | 0.01 | 0.612 | 0.0584 | 0.992 |
HCC70 | GDC-0980 | 1 | 72 | sigmoid | sigmoid | HCC70 apitolisib 0 1 72 | 8 | 1.350 | 0.211 | -0.312 | 0.362 | 0.339 | -0.362 | 1.15 | 0.985 | 3.24e-06 | NA | 0.441 | 0.237 | 0.779 | 0.266 | 0.236 | 1.26 | 0.985 | 3.31e-06 | NA |
HCC70 | Omipalisib | 1 | 72 | sigmoid | sigmoid | HCC70 omipalisib 0 1 72 | 8 | 1.358 | 0.00496 | -0.785 | 1.14 | 0.0157 | -0.775 | 0.812 | 0.989 | 1.34e-06 | NA | 0.0123 | 0.0486 | 0.349 | 0.011 | 0.0462 | 0.833 | 0.984 | 3.73e-06 | NA |
HCC70 | Torin2 | 1 | 72 | sigmoid | sigmoid | HCC70 Torin2 0 1 72 | 8 | 1.364 | 0.0288 | -0.732 | 0.772 | 0.183 | -1.0 | 0.594 | 0.991 | 6.58e-07 | NA | 0.088 | 0.0644 | 0.539 | 0.088 | 0.0 | 0.622 | 0.988 | 1.95e-06 | NA |
HCC70 | Everolimus | 1 | 72 | flat | flat | HCC70 everolimus 0 1 72 | 8 | 1.366 | Inf | 0.569 | 0.354 | 0.0 | 0.569 | 0.01 | 0.623 | 0.0534 | 0.643 | Inf | 0.718 | 0.766 | 0.0 | 0.718 | 0.01 | 0.62 | 0.0547 | 0.765 |
HCC70 | AZD-6482 | 1 | 72 | sigmoid | sigmoid | HCC70 AZD6482 0 1 72 | 8 | 1.368 | 0.0982 | 0.0128 | 0.462 | 0.205 | -0.212 | 0.481 | 0.975 | 1.49e-05 | NA | 0.767 | 0.394 | 0.704 | 0.121 | 0.305 | 0.509 | 0.973 | 1.9e-05 | NA |
HCC70 | Buparlisib | 1 | 72 | sigmoid | sigmoid | HCC70 buparlisib 0 1 72 | 8 | 1.374 | 0.608 | -0.494 | 0.231 | 1.27 | -0.9 | 1.4 | 0.98 | 7.6e-06 | NA | 0.988 | 0.151 | 0.861 | 0.98 | 0.00578 | 1.46 | 0.973 | 1.91e-05 | NA |
HCC70 | TGX221 | 1 | 72 | sigmoid | sigmoid | HCC70 TGX-221 0 1 72 | 8 | 1.381 | 0.539 | 0.344 | 0.244 | 0.245 | 0.278 | 1.03 | 0.986 | 2.58e-06 | NA | Inf | 0.578 | 0.84 | 0.229 | 0.536 | 1.02 | 0.986 | 2.87e-06 | NA |
HCC38 | PIK-93 | 3 | 72 | sigmoid | sigmoid | HCC38 PIK-93 0 3 72 | 8 | 1.382 | 5.05 | 0.598 | 0.061 | 2.34 | 0.358 | 1.63 | 0.919 | 0.000533 | NA | Inf | 0.734 | 0.959 | 2.23 | 0.586 | 1.64 | 0.914 | 0.000645 | NA |
HCC70 | WYE-125132 | 1 | 72 | sigmoid | sigmoid | HCC70 WYE-132 0 1 72 | 8 | 1.382 | 0.0518 | 0.346 | 0.418 | 0.0175 | 0.348 | 1.1 | 0.985 | 3.58e-06 | NA | Inf | 0.579 | 0.727 | 0.0165 | 0.579 | 1.09 | 0.983 | 4.63e-06 | NA |
HCC70 | Alpelisib | 1 | 72 | sigmoid | sigmoid | HCC70 alpelisib 0 1 72 | 8 | 1.383 | 4.4 | 0.574 | 0.105 | 20.4 | -1.0 | 0.717 | 0.78 | 0.0106 | NA | 11.9 | 0.718 | 0.929 | 11.9 | 0.0 | 0.732 | 0.768 | 0.0124 | NA |
HCC70 | CAL-101 | 1 | 72 | sigmoid | sigmoid | HCC70 idelalisib 0 1 72 | 8 | 1.384 | 2.78 | 0.485 | 0.0894 | 0.883 | 0.424 | 1.65 | 0.972 | 2.11e-05 | NA | Inf | 0.662 | 0.941 | 0.846 | 0.626 | 1.66 | 0.97 | 2.79e-05 | NA |
HCC38 | Torin2 | 3 | 72 | sigmoid | sigmoid | HCC38 Torin2 0 3 72 | 8 | 1.385 | 0.013 | -0.624 | 0.855 | 0.0547 | -0.706 | 0.615 | 0.996 | 8.13e-08 | NA | 0.0407 | 0.0986 | 0.484 | 0.0311 | 0.0829 | 0.669 | 0.997 | 3.31e-08 | NA |
HCC70 | AS605240 | 1 | 72 | sigmoid | sigmoid | HCC70 AS-605240 0 1 72 | 8 | 1.387 | 10.4 | 0.487 | 0.159 | 0.247 | 0.497 | 1.34 | 0.963 | 5.14e-05 | NA | Inf | 0.663 | 0.894 | 0.23 | 0.672 | 1.39 | 0.961 | 6.01e-05 | NA |
HCC70 | XL147 | 1 | 72 | flat | flat | HCC70 pilaralisib 0 1 72 | 8 | 1.396 | Inf | 1.05 | -0.0406 | 0.0 | 1.05 | 0.01 | -0.285 | 1.0 | 1.03 | Inf | 1.04 | 1.03 | 0.0 | 1.04 | 0.01 | -0.295 | 1.0 | 1.02 |
HCC38 | Alpelisib | 3 | 72 | flat | flat | HCC38 alpelisib 0 3 72 | 8 | 1.398 | Inf | 0.75 | 0.0995 | 0.0 | 0.75 | 0.01 | 0.141 | 0.634 | 0.883 | Inf | 0.829 | 0.932 | 0.0 | 0.829 | 0.01 | 0.113 | 0.698 | 0.92 |
HCC70 | Dactolisib | 1 | 72 | sigmoid | sigmoid | HCC70 dactolisib 0 1 72 | 8 | 1.400 | 0.0808 | -0.0667 | 0.501 | 3.34 | -1.0 | 0.295 | 0.963 | 5.02e-05 | NA | 0.753 | 0.344 | 0.673 | 0.753 | 0.0 | 0.308 | 0.962 | 5.37e-05 | NA |
HCC70 | Pictilisib | 1 | 72 | sigmoid | sigmoid | HCC70 pictilisib 0 1 72 | 8 | 1.409 | 0.408 | -0.099 | 0.284 | 0.578 | -0.245 | 1.14 | 0.996 | 7.62e-08 | NA | 0.888 | 0.325 | 0.816 | 0.477 | 0.261 | 1.19 | 0.995 | 1.2e-07 | NA |
HCC70 | Sirolimus | 1 | 72 | sigmoid | sigmoid | HCC70 rapamycin 0 1 72 | 8 | 1.416 | 37.6 | 0.533 | 0.397 | 0.00426 | 0.298 | 0.1 | 0.742 | 0.0172 | NA | 125000000.0 | 0.687 | 0.732 | 0.00186 | 0.541 | 0.1 | 0.74 | 0.0175 | NA |
HCC38 | AZD8055 | 3 | 72 | sigmoid | sigmoid | HCC38 AZD8055 0 3 72 | 8 | 1.417 | 0.0464 | 0.0327 | 0.53 | 0.0463 | 0.000983 | 1.04 | 0.997 | 4.27e-08 | NA | 0.157 | 0.392 | 0.658 | 0.041 | 0.372 | 1.02 | 0.996 | 5.78e-08 | NA |