Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
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Hs 578T | XL147 | 2 | flat | flat | Hs578T pilaralisib 2 | 8 | 2.509 | Inf | 0.976 | 0.000255 | 0.0 | 0.976 | 0.01 | 0.435 | 0.181 | 0.997 | Inf | 0.97 | 1.0 | 0.0 | 0.97 | 0.01 | 0.432 | 0.183 | 0.996 | |
HCC1806 | XL147 | 3 | 72 | flat | flat | HCC1806 pilaralisib 0 3 72 | 8 | 3.185 | Inf | 1.02 | 0.000871 | 0.0 | 1.02 | 0.01 | -2.12e-06 | 1.0 | 1.0 | Inf | 1.03 | 0.999 | 0.0 | 1.03 | 0.01 | -0.000107 | 1.0 | 1.0 |
HCC1806 | XL147 | 2 | 72 | flat | flat | HCC1806 pilaralisib 0 2 72 | 8 | 2.817 | Inf | 1.02 | 0.000975 | 0.0 | 1.02 | 0.01 | -4.46e-06 | 1.0 | 1.0 | Inf | 1.03 | 0.999 | 0.0 | 1.03 | 0.01 | -0.000109 | 1.0 | 1.0 |
HCC1806 | XL147 | 1 | 72 | flat | flat | HCC1806 pilaralisib 0 1 72 | 8 | 2.732 | Inf | 1.02 | 0.00101 | 0.0 | 1.02 | 0.01 | -4.53e-06 | 1.0 | 1.0 | Inf | 1.03 | 0.999 | 0.0 | 1.03 | 0.01 | -0.000107 | 1.0 | 1.0 |
HCC1806 | AZD-6482 | 3 | 72 | flat | flat | HCC1806 AZD6482 0 3 72 | 8 | 3.201 | Inf | 1.0 | 0.00122 | 0.0 | 1.0 | 0.01 | -0.0063 | 1.0 | 0.999 | Inf | 1.01 | 0.998 | 0.0 | 1.01 | 0.01 | -0.00515 | 1.0 | 0.998 |
HCC1806 | AZD-6482 | 2 | 72 | flat | flat | HCC1806 AZD6482 0 2 72 | 8 | 2.833 | Inf | 1.0 | 0.00136 | 0.0 | 1.0 | 0.01 | -0.0062 | 1.0 | 0.999 | Inf | 1.01 | 0.998 | 0.0 | 1.01 | 0.01 | -0.00512 | 1.0 | 0.998 |
HCC1806 | AZD-6482 | 1 | 72 | flat | flat | HCC1806 AZD6482 0 1 72 | 8 | 2.748 | Inf | 1.0 | 0.00141 | 0.0 | 1.0 | 0.01 | -0.00621 | 1.0 | 0.999 | Inf | 1.01 | 0.998 | 0.0 | 1.01 | 0.01 | -0.00515 | 1.0 | 0.998 |
HCC38 | CAL-101 | 1 | 72 | sigmoid | sigmoid | HCC38 idelalisib 0 1 72 | 8 | 1.723 | Inf | 0.92 | 0.00328 | 1.18 | 0.903 | 1.47 | 0.768 | 0.0125 | NA | Inf | 0.932 | 0.997 | 1.16 | 0.918 | 1.48 | 0.763 | 0.0133 | NA |
BT-20 | TGX221 | 1 | 72 | flat | flat | BT20 TGX-221 0 1 72 | 8 | 1.988 | Inf | 1.02 | -0.00357 | 0.0 | 1.02 | 0.01 | -0.00762 | 1.0 | 1.0 | Inf | 1.02 | 1.0 | 0.0 | 1.02 | 0.01 | -0.00881 | 1.0 | 1.0 |
Hs 578T | XL147 | 1 | flat | flat | Hs578T pilaralisib 1 | 8 | 2.013 | Inf | 0.967 | 0.00411 | 0.0 | 0.967 | 0.01 | 0.193 | 0.525 | 0.991 | Inf | 0.967 | 0.996 | 0.0 | 0.967 | 0.01 | 0.196 | 0.519 | 0.991 | |
BT-549 | KIN001-244 | 2 | 72 | sigmoid | sigmoid | BT549 KIN001-244 0 2 72 | 8 | 1.920 | Inf | 0.882 | 0.00561 | 2.72 | 0.793 | 1.67 | 0.73 | 0.0197 | NA | Inf | 0.89 | 0.995 | 2.6 | 0.813 | 1.68 | 0.718 | 0.0225 | NA |
HCC1806 | PI103 | 3 | 72 | sigmoid | sigmoid | HCC1806 PI-103 0 3 72 | 8 | 3.126 | Inf | 0.91 | 0.00588 | 1.72 | 0.873 | 1.43 | 0.782 | 0.0103 | NA | Inf | 0.866 | 0.992 | 1.61 | 0.817 | 1.44 | 0.762 | 0.0134 | NA |
Hs 578T | XL147 | 3 | flat | flat | Hs578T pilaralisib 3 | 8 | 2.879 | Inf | 0.971 | -0.00618 | 0.0 | 0.971 | 0.01 | 0.331 | 0.299 | 1.0 | Inf | 0.959 | 1.01 | 0.0 | 0.959 | 0.01 | 0.319 | 0.315 | 1.0 | |
HCC1806 | PI103 | 2 | 72 | sigmoid | sigmoid | HCC1806 PI-103 0 2 72 | 8 | 2.758 | Inf | 0.898 | 0.00662 | 1.71 | 0.857 | 1.43 | 0.781 | 0.0105 | NA | Inf | 0.866 | 0.992 | 1.61 | 0.817 | 1.44 | 0.762 | 0.0134 | NA |
HCC1806 | PI103 | 1 | 72 | sigmoid | sigmoid | HCC1806 PI-103 0 1 72 | 8 | 2.673 | Inf | 0.895 | 0.00682 | 1.71 | 0.853 | 1.43 | 0.781 | 0.0106 | NA | Inf | 0.866 | 0.992 | 1.61 | 0.817 | 1.44 | 0.762 | 0.0134 | NA |
HCC70 | KIN001-244 | 1 | 72 | flat | flat | HCC70 KIN001-244 0 1 72 | 8 | 1.350 | Inf | 0.889 | 0.00722 | 0.0 | 0.889 | 0.01 | 0.616 | 0.0568 | 0.988 | Inf | 0.926 | 0.995 | 0.0 | 0.926 | 0.01 | 0.612 | 0.0584 | 0.992 |
BT-549 | XL147 | 2 | 72 | flat | flat | BT549 pilaralisib 0 2 72 | 8 | 1.952 | Inf | 0.967 | -0.00824 | 0.0 | 0.967 | 0.01 | -0.000427 | 1.0 | 1.0 | Inf | 0.968 | 1.01 | 0.0 | 0.968 | 0.01 | -0.000878 | 1.0 | 1.0 |
HCC1806 | CAL-101 | 3 | 72 | flat | flat | HCC1806 idelalisib 0 3 72 | 8 | 3.147 | Inf | 1.02 | -0.00869 | 0.0 | 1.02 | 0.01 | -0.594 | 1.0 | 1.01 | Inf | 1.03 | 1.01 | 0.0 | 1.03 | 0.01 | -0.587 | 1.0 | 1.02 |
Hs 578T | KIN001-244 | 3 | sigmoid | sigmoid | Hs578T KIN001-244 3 | 8 | 2.888 | Inf | 0.866 | 0.00909 | 5.05 | 0.617 | 1.35 | 0.858 | 0.00289 | NA | 50.0 | 0.818 | 0.988 | 5.2 | 0.474 | 1.31 | 0.842 | 0.00391 | NA | |
HCC1806 | CAL-101 | 2 | 72 | flat | flat | HCC1806 idelalisib 0 2 72 | 8 | 2.779 | Inf | 1.02 | -0.00985 | 0.0 | 1.02 | 0.01 | -0.594 | 1.0 | 1.01 | Inf | 1.03 | 1.01 | 0.0 | 1.03 | 0.01 | -0.588 | 1.0 | 1.02 |
HCC1806 | TGX221 | 3 | 72 | flat | flat | HCC1806 TGX-221 0 3 72 | 8 | 3.132 | Inf | 1.0 | -0.0101 | 0.0 | 1.0 | 0.01 | -1.16 | 1.0 | 1.01 | Inf | 1.0 | 1.02 | 0.0 | 1.0 | 0.01 | -1.16 | 1.0 | 1.02 |
HCC1806 | CAL-101 | 1 | 72 | flat | flat | HCC1806 idelalisib 0 1 72 | 8 | 2.695 | Inf | 1.02 | -0.0102 | 0.0 | 1.02 | 0.01 | -0.593 | 1.0 | 1.01 | Inf | 1.03 | 1.01 | 0.0 | 1.03 | 0.01 | -0.587 | 1.0 | 1.02 |
HCC1806 | AS605240 | 3 | 72 | sigmoid | sigmoid | HCC1806 AS-605240 0 3 72 | 8 | 3.181 | Inf | 0.923 | 0.011 | 0.57 | 0.923 | 2.81 | 0.936 | 0.000257 | NA | Inf | 0.883 | 0.983 | 0.559 | 0.882 | 2.81 | 0.931 | 0.000333 | NA |
HCC1806 | TGX221 | 2 | 72 | flat | flat | HCC1806 TGX-221 0 2 72 | 8 | 2.763 | Inf | 1.0 | -0.0114 | 0.0 | 1.0 | 0.01 | -1.16 | 1.0 | 1.01 | Inf | 1.0 | 1.02 | 0.0 | 1.0 | 0.01 | -1.16 | 1.0 | 1.02 |
HCC38 | TGX221 | 1 | 72 | sigmoid | sigmoid | HCC38 TGX-221 0 1 72 | 8 | 1.724 | Inf | 0.938 | 0.0116 | 0.289 | 0.941 | 5.0 | 0.676 | 0.0342 | NA | Inf | 0.947 | 0.99 | 0.289 | 0.949 | 5.0 | 0.672 | 0.0354 | NA |