Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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  • Page 1 of 18
  • 1 to 25 of 432 records
Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
Hs 578T XL147 2
flat
flat
Hs578T pilaralisib 2
8 2.509
Inf
0.976
0.000255
0.0
0.976
0.01
0.435
0.181
0.997
Inf
0.97
1.0
0.0
0.97
0.01
0.432
0.183
0.996
HCC1806 XL147 3 72
flat
flat
HCC1806 pilaralisib 0 3 72
8 3.185
Inf
1.02
0.000871
0.0
1.02
0.01
-2.12e-06
1.0
1.0
Inf
1.03
0.999
0.0
1.03
0.01
-0.000107
1.0
1.0
HCC1806 XL147 2 72
flat
flat
HCC1806 pilaralisib 0 2 72
8 2.817
Inf
1.02
0.000975
0.0
1.02
0.01
-4.46e-06
1.0
1.0
Inf
1.03
0.999
0.0
1.03
0.01
-0.000109
1.0
1.0
HCC1806 XL147 1 72
flat
flat
HCC1806 pilaralisib 0 1 72
8 2.732
Inf
1.02
0.00101
0.0
1.02
0.01
-4.53e-06
1.0
1.0
Inf
1.03
0.999
0.0
1.03
0.01
-0.000107
1.0
1.0
HCC1806 AZD-6482 3 72
flat
flat
HCC1806 AZD6482 0 3 72
8 3.201
Inf
1.0
0.00122
0.0
1.0
0.01
-0.0063
1.0
0.999
Inf
1.01
0.998
0.0
1.01
0.01
-0.00515
1.0
0.998
HCC1806 AZD-6482 2 72
flat
flat
HCC1806 AZD6482 0 2 72
8 2.833
Inf
1.0
0.00136
0.0
1.0
0.01
-0.0062
1.0
0.999
Inf
1.01
0.998
0.0
1.01
0.01
-0.00512
1.0
0.998
HCC1806 AZD-6482 1 72
flat
flat
HCC1806 AZD6482 0 1 72
8 2.748
Inf
1.0
0.00141
0.0
1.0
0.01
-0.00621
1.0
0.999
Inf
1.01
0.998
0.0
1.01
0.01
-0.00515
1.0
0.998
HCC38 CAL-101 1 72
sigmoid
sigmoid
HCC38 idelalisib 0 1 72
8 1.723
Inf
0.92
0.00328
1.18
0.903
1.47
0.768
0.0125
NA
Inf
0.932
0.997
1.16
0.918
1.48
0.763
0.0133
NA
BT-20 TGX221 1 72
flat
flat
BT20 TGX-221 0 1 72
8 1.988
Inf
1.02
-0.00357
0.0
1.02
0.01
-0.00762
1.0
1.0
Inf
1.02
1.0
0.0
1.02
0.01
-0.00881
1.0
1.0
Hs 578T XL147 1
flat
flat
Hs578T pilaralisib 1
8 2.013
Inf
0.967
0.00411
0.0
0.967
0.01
0.193
0.525
0.991
Inf
0.967
0.996
0.0
0.967
0.01
0.196
0.519
0.991
BT-549 KIN001-244 2 72
sigmoid
sigmoid
BT549 KIN001-244 0 2 72
8 1.920
Inf
0.882
0.00561
2.72
0.793
1.67
0.73
0.0197
NA
Inf
0.89
0.995
2.6
0.813
1.68
0.718
0.0225
NA
HCC1806 PI103 3 72
sigmoid
sigmoid
HCC1806 PI-103 0 3 72
8 3.126
Inf
0.91
0.00588
1.72
0.873
1.43
0.782
0.0103
NA
Inf
0.866
0.992
1.61
0.817
1.44
0.762
0.0134
NA
Hs 578T XL147 3
flat
flat
Hs578T pilaralisib 3
8 2.879
Inf
0.971
-0.00618
0.0
0.971
0.01
0.331
0.299
1.0
Inf
0.959
1.01
0.0
0.959
0.01
0.319
0.315
1.0
HCC1806 PI103 2 72
sigmoid
sigmoid
HCC1806 PI-103 0 2 72
8 2.758
Inf
0.898
0.00662
1.71
0.857
1.43
0.781
0.0105
NA
Inf
0.866
0.992
1.61
0.817
1.44
0.762
0.0134
NA
HCC1806 PI103 1 72
sigmoid
sigmoid
HCC1806 PI-103 0 1 72
8 2.673
Inf
0.895
0.00682
1.71
0.853
1.43
0.781
0.0106
NA
Inf
0.866
0.992
1.61
0.817
1.44
0.762
0.0134
NA
HCC70 KIN001-244 1 72
flat
flat
HCC70 KIN001-244 0 1 72
8 1.350
Inf
0.889
0.00722
0.0
0.889
0.01
0.616
0.0568
0.988
Inf
0.926
0.995
0.0
0.926
0.01
0.612
0.0584
0.992
BT-549 XL147 2 72
flat
flat
BT549 pilaralisib 0 2 72
8 1.952
Inf
0.967
-0.00824
0.0
0.967
0.01
-0.000427
1.0
1.0
Inf
0.968
1.01
0.0
0.968
0.01
-0.000878
1.0
1.0
HCC1806 CAL-101 3 72
flat
flat
HCC1806 idelalisib 0 3 72
8 3.147
Inf
1.02
-0.00869
0.0
1.02
0.01
-0.594
1.0
1.01
Inf
1.03
1.01
0.0
1.03
0.01
-0.587
1.0
1.02
Hs 578T KIN001-244 3
sigmoid
sigmoid
Hs578T KIN001-244 3
8 2.888
Inf
0.866
0.00909
5.05
0.617
1.35
0.858
0.00289
NA
50.0
0.818
0.988
5.2
0.474
1.31
0.842
0.00391
NA
HCC1806 CAL-101 2 72
flat
flat
HCC1806 idelalisib 0 2 72
8 2.779
Inf
1.02
-0.00985
0.0
1.02
0.01
-0.594
1.0
1.01
Inf
1.03
1.01
0.0
1.03
0.01
-0.588
1.0
1.02
HCC1806 TGX221 3 72
flat
flat
HCC1806 TGX-221 0 3 72
8 3.132
Inf
1.0
-0.0101
0.0
1.0
0.01
-1.16
1.0
1.01
Inf
1.0
1.02
0.0
1.0
0.01
-1.16
1.0
1.02
HCC1806 CAL-101 1 72
flat
flat
HCC1806 idelalisib 0 1 72
8 2.695
Inf
1.02
-0.0102
0.0
1.02
0.01
-0.593
1.0
1.01
Inf
1.03
1.01
0.0
1.03
0.01
-0.587
1.0
1.02
HCC1806 AS605240 3 72
sigmoid
sigmoid
HCC1806 AS-605240 0 3 72
8 3.181
Inf
0.923
0.011
0.57
0.923
2.81
0.936
0.000257
NA
Inf
0.883
0.983
0.559
0.882
2.81
0.931
0.000333
NA
HCC1806 TGX221 2 72
flat
flat
HCC1806 TGX-221 0 2 72
8 2.763
Inf
1.0
-0.0114
0.0
1.0
0.01
-1.16
1.0
1.01
Inf
1.0
1.02
0.0
1.0
0.01
-1.16
1.0
1.02
HCC38 TGX221 1 72
sigmoid
sigmoid
HCC38 TGX-221 0 1 72
8 1.724
Inf
0.938
0.0116
0.289
0.941
5.0
0.676
0.0342
NA
Inf
0.947
0.99
0.289
0.949
5.0
0.672
0.0354
NA
  • Page 1 of 18
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