Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
BT-20	Sirolimus	3	72	flat	flat	BT20 rapamycin 0 3 72	8	2.661	Inf	0.54	0.46	0.0	0.54	0.01	NA	NA	0.54	Inf	0.499	0.499	0.0	0.499	0.01	NA	NA	0.499
BT-20	Sirolimus	2	72	flat	flat	BT20 rapamycin 0 2 72	8	1.952	Inf	0.421	0.579	0.0	0.421	0.01	NA	NA	0.421	Inf	0.513	0.513	0.0	0.513	0.01	NA	NA	0.513
BT-20	Everolimus	2	72	flat	flat	BT20 everolimus 0 2 72	8	1.785	Inf	0.426	0.574	0.0	0.426	0.01	NA	NA	0.426	Inf	0.547	0.547	0.0	0.547	0.01	NA	NA	0.547
HCC38	Omipalisib	2	72	sigmoid	sigmoid	HCC38 omipalisib 0 2 72	8	2.124	0.0404	-0.47	0.634	0.45	-1.0	0.456	0.979	9.71e-06	NA	0.0507	0.0595	0.494	0.0507	0.0	0.556	0.96	6.44e-05	NA
HCC38	WYE-125132	3	72	sigmoid	sigmoid	HCC38 WYE-132 0 3 72	8	1.449	0.0494	-0.0216	0.518	0.0504	-0.0117	1.18	0.998	9.69e-09	NA	0.128	0.355	0.662	0.0441	0.361	1.2	0.998	9.53e-09	NA
HCC38	WYE-125132	2	72	sigmoid	sigmoid	HCC38 WYE-132 0 2 72	8	2.143	0.0568	0.149	0.473	0.0413	0.124	0.896	0.998	9.66e-09	NA	0.078	0.305	0.587	0.0297	0.285	0.875	0.997	1.58e-08	NA
HCC70	Dactolisib	2	72	sigmoid	sigmoid	HCC70 dactolisib 0 2 72	8	1.677	0.312	0.238	0.341	0.195	0.103	0.493	0.954	9.66e-05	NA	2.24	0.447	0.738	0.0858	0.419	0.56	0.954	9.8e-05	NA
BT-549	Pictilisib	3	72	sigmoid	sigmoid	BT549 pictilisib 0 3 72	8	1.767	1.42	0.276	0.169	4.62	-0.67	0.722	0.998	9.61e-09	NA	2.47	0.452	0.863	2.47	0.0	0.742	0.997	2.13e-08	NA
BT-20	Pictilisib	3	72	sigmoid	sigmoid	BT20 pictilisib 0 3 72	8	2.566	0.839	0.172	0.22	0.914	-0.0483	1.09	0.954	9.59e-05	NA	0.843	0.254	0.768	0.809	0.0179	0.898	0.918	0.000551	NA
HCC38	BX-912	2	72	sigmoid	sigmoid	HCC38 BX-912 0 2 72	8	2.186	0.583	-0.229	0.251	0.648	-0.233	3.62	0.999	9.58e-10	NA	0.602	0.124	0.807	0.559	0.123	3.78	0.998	1.03e-08	NA
Hs 578T	CAL-101	2		sigmoid	sigmoid	Hs578T idelalisib 2	8	2.534	57.5	0.801	0.0636	320.0	-0.507	0.408	0.979	9.58e-06	NA	Inf	0.766	0.923	4.27	0.505	0.495	0.975	1.65e-05	NA
Hs 578T	Alpelisib	1		sigmoid	sigmoid	Hs578T alpelisib 1	8	2.097	2.3	0.449	0.205	42.0	-1.0	0.378	0.954	9.56e-05	NA	3.9	0.508	0.803	3.9	0.0	0.401	0.94	0.000216	NA
HCC38	Buparlisib	1	72	sigmoid	sigmoid	HCC38 buparlisib 0 1 72	8	1.738	0.912	-0.226	0.194	1.46	-0.57	1.62	0.999	9.48e-10	NA	1.2	0.192	0.858	1.12	0.0495	1.66	0.998	4.36e-09	NA
HCC38	GDC-0980	1	72	sigmoid	sigmoid	HCC38 apitolisib 0 1 72	8	1.777	0.317	0.114	0.305	0.295	0.0315	0.91	0.99	9.47e-07	NA	0.623	0.354	0.761	0.219	0.315	0.951	0.989	1.26e-06	NA
HCC70	Torin2	2	72	sigmoid	sigmoid	HCC70 Torin2 0 2 72	8	1.826	0.0342	-0.522	0.671	0.401	-1.0	0.446	0.979	9.23e-06	NA	0.0639	0.0733	0.507	0.0639	0.0	0.462	0.969	2.98e-05	NA
BT-20	Dactolisib	1	72	sigmoid	sigmoid	BT20 dactolisib 0 1 72	8	2.055	0.0223	-0.205	0.652	0.0609	-0.33	0.505	0.979	9.18e-06	NA	0.0305	0.15	0.475	0.0171	0.153	0.631	0.979	9.75e-06	NA
Hs 578T	Pictilisib	2		sigmoid	sigmoid	Hs578T pictilisib 2	8	2.512	1.93	0.45	0.194	0.4	0.333	0.696	0.98	8e-06	NA	1.58	0.446	0.787	0.231	0.381	0.746	0.974	1.74e-05	NA
Hs 578T	Pictilisib	1		sigmoid	sigmoid	Hs578T pictilisib 1	8	2.048	0.482	0.341	0.267	0.162	0.295	0.819	0.998	8.97e-09	NA	0.981	0.441	0.759	0.12	0.416	0.847	0.998	6.97e-09	NA
HCC70	Omipalisib	3	72	sigmoid	sigmoid	HCC70 omipalisib 0 3 72	8	2.458	0.0158	-0.404	0.771	0.0319	-0.379	0.8	0.99	8.95e-07	NA	0.0148	0.051	0.376	0.0127	0.0733	1.02	0.996	4.59e-08	NA
Hs 578T	WYE-125132	2		sigmoid	sigmoid	Hs578T WYE-132 2	8	2.544	0.0374	0.152	0.505	0.0268	0.147	1.04	0.999	8.81e-10	NA	0.0344	0.246	0.516	0.0183	0.239	1.03	0.999	2.53e-09	NA
BT-549	PIK-93	2	72	sigmoid	sigmoid	BT549 PIK-93 0 2 72	8	1.983	7.03	0.687	0.0641	29.9	-1.0	0.759	0.956	8.81e-05	NA	10.4	0.713	0.939	10.4	0.0	0.788	0.949	0.000136	NA
Hs 578T	Omipalisib	3		sigmoid	sigmoid	Hs578T omipalisib 3	8	2.869	0.0255	-0.107	0.615	0.0533	-0.22	0.494	0.99	8.79e-07	NA	0.0145	0.0989	0.392	0.0102	0.0968	0.62	0.993	3.4e-07	NA
HCC70	AZD8055	3	72	sigmoid	sigmoid	HCC70 AZD8055 0 3 72	8	2.442	Inf	0.571	0.287	0.0133	0.574	1.17	0.98	8.55e-06	NA	Inf	0.554	0.694	0.0116	0.556	1.17	0.974	1.69e-05	NA
BT-549	Torin2	3	72	sigmoid	sigmoid	BT549 Torin2 0 3 72	8	1.613	0.00797	-0.254	0.794	0.0216	-0.338	0.517	0.98	8.52e-06	NA	0.0236	0.204	0.458	0.0104	0.191	0.585	0.976	1.3e-05	NA
HCC38	MK2206	1	72	sigmoid	sigmoid	HCC38 MK-2206 0 1 72	8	1.789	19.4	0.698	0.0995	320.0	-0.949	0.38	0.956	8.33e-05	NA	61.8	0.746	0.914	61.8	0.0	0.386	0.951	0.000115	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)