Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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| Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | MK2206 | 2 | 72 | sigmoid | sigmoid | BT549 MK-2206 0 2 72 | 8 | 1.871 | Inf | 0.926 | 0.0188 | 0.107 | 0.926 | 5.0 | 0.816 | 0.00627 | NA | Inf | 0.932 | 0.983 | 0.107 | 0.931 | 5.0 | 0.809 | 0.00694 | NA |
| BT-549 | BX-912 | 2 | 72 | sigmoid | sigmoid | BT549 BX-912 0 2 72 | 8 | 1.948 | 1.04 | 0.33 | 0.126 | 0.84 | 0.329 | 5.0 | 0.99 | 1.01e-06 | NA | 1.28 | 0.452 | 0.892 | 0.808 | 0.451 | 5.0 | 0.987 | 2.4e-06 | NA |
| HCC38 | BX-912 | 3 | 72 | sigmoid | sigmoid | HCC38 BX-912 0 3 72 | 8 | 1.454 | 0.422 | -0.428 | 0.365 | 0.478 | -0.433 | 5.0 | 0.993 | 4.02e-07 | NA | 0.496 | 0.162 | 0.778 | 0.46 | 0.159 | 5.0 | 0.989 | 1.24e-06 | NA |
| HCC38 | AZD-6482 | 3 | 72 | sigmoid | sigmoid | HCC38 AZD6482 0 3 72 | 8 | 1.420 | Inf | 0.821 | 0.0615 | 0.324 | 0.826 | 5.0 | 0.849 | 0.00342 | NA | Inf | 0.875 | 0.957 | 0.323 | 0.879 | 5.0 | 0.846 | 0.00367 | NA |
| HCC70 | BX-912 | 2 | 72 | sigmoid | sigmoid | HCC70 BX-912 0 2 72 | 8 | 1.693 | 1.25 | 0.00257 | 0.0619 | 1.25 | -0.00649 | 5.0 | 0.971 | 2.55e-05 | NA | 1.44 | 0.311 | 0.961 | 1.2 | 0.306 | 5.0 | 0.956 | 8.35e-05 | NA |
| HCC38 | TGX221 | 1 | 72 | sigmoid | sigmoid | HCC38 TGX-221 0 1 72 | 8 | 1.724 | Inf | 0.938 | 0.0116 | 0.289 | 0.941 | 5.0 | 0.676 | 0.0342 | NA | Inf | 0.947 | 0.99 | 0.289 | 0.949 | 5.0 | 0.672 | 0.0354 | NA |
| HCC70 | BX-912 | 3 | 72 | sigmoid | sigmoid | HCC70 BX-912 0 3 72 | 8 | 2.465 | 1.26 | 0.174 | 0.0739 | 1.16 | 0.168 | 5.0 | 0.988 | 1.75e-06 | NA | 1.26 | 0.269 | 0.935 | 1.08 | 0.265 | 5.0 | 0.977 | 1.15e-05 | NA |
| HCC38 | XL147 | 3 | 72 | sigmoid | sigmoid | HCC38 pilaralisib 0 3 72 | 8 | 1.420 | Inf | 0.909 | 0.0219 | 0.114 | 0.921 | 5.0 | 0.815 | 0.00631 | NA | Inf | 0.936 | 0.985 | 0.114 | 0.945 | 5.0 | 0.813 | 0.00654 | NA |
| HCC1806 | ZSTK474 | 3 | 72 | sigmoid | sigmoid | HCC1806 ZSTK474 0 3 72 | 8 | 3.162 | Inf | 0.654 | 0.0322 | 1.18 | 0.65 | 4.68 | 0.99 | 1.03e-06 | NA | Inf | 0.548 | 0.958 | 1.12 | 0.545 | 4.88 | 0.985 | 3.14e-06 | NA |
| HCC1806 | ZSTK474 | 1 | 72 | sigmoid | sigmoid | HCC1806 ZSTK474 0 1 72 | 8 | 2.709 | Inf | 0.602 | 0.037 | 1.17 | 0.599 | 4.88 | 0.99 | 1.12e-06 | NA | Inf | 0.548 | 0.958 | 1.12 | 0.545 | 4.88 | 0.985 | 3.14e-06 | NA |
| HCC1806 | ZSTK474 | 2 | 72 | sigmoid | sigmoid | HCC1806 ZSTK474 0 2 72 | 8 | 2.794 | Inf | 0.613 | 0.036 | 1.16 | 0.61 | 5.0 | 0.99 | 1.1e-06 | NA | Inf | 0.548 | 0.958 | 1.12 | 0.545 | 4.88 | 0.985 | 3.14e-06 | NA |
| HCC38 | BX-912 | 1 | 72 | sigmoid | sigmoid | HCC38 BX-912 0 1 72 | 8 | 1.760 | 0.529 | -0.322 | 0.274 | 0.591 | -0.322 | 4.49 | 0.999 | 1.36e-10 | NA | 0.584 | 0.149 | 0.818 | 0.541 | 0.149 | 4.63 | 0.999 | 8.39e-10 | NA |
| BT-549 | BX-912 | 3 | 72 | sigmoid | sigmoid | BT549 BX-912 0 3 72 | 8 | 1.728 | 1.0 | 0.335 | 0.109 | 0.758 | 0.332 | 3.91 | 0.993 | 2.87e-07 | NA | 2.46 | 0.497 | 0.916 | 0.73 | 0.496 | 3.92 | 0.992 | 6.03e-07 | NA |
| HCC70 | BX-912 | 1 | 72 | sigmoid | sigmoid | HCC70 BX-912 0 1 72 | 8 | 1.436 | 1.08 | -0.227 | 0.134 | 1.2 | -0.255 | 3.86 | 0.99 | 1.07e-06 | NA | 1.35 | 0.256 | 0.916 | 1.14 | 0.242 | 3.87 | 0.986 | 2.78e-06 | NA |
| HCC38 | BX-912 | 2 | 72 | sigmoid | sigmoid | HCC38 BX-912 0 2 72 | 8 | 2.186 | 0.583 | -0.229 | 0.251 | 0.648 | -0.233 | 3.62 | 0.999 | 9.58e-10 | NA | 0.602 | 0.124 | 0.807 | 0.559 | 0.123 | 3.78 | 0.998 | 1.03e-08 | NA |
| HCC38 | CAL-101 | 2 | 72 | sigmoid | sigmoid | HCC38 idelalisib 0 2 72 | 8 | 2.154 | Inf | 0.881 | 0.0205 | 0.901 | 0.879 | 3.37 | 0.892 | 0.00125 | NA | Inf | 0.876 | 0.979 | 0.891 | 0.874 | 3.37 | 0.887 | 0.00144 | NA |
| BT-549 | MK2206 | 3 | 72 | sigmoid | sigmoid | BT549 MK-2206 0 3 72 | 8 | 1.685 | Inf | 0.714 | 0.131 | 0.123 | 0.711 | 3.44 | 0.953 | 0.000102 | NA | Inf | 0.771 | 0.895 | 0.123 | 0.768 | 3.25 | 0.949 | 0.000136 | NA |
| BT-549 | BX-912 | 1 | 72 | sigmoid | sigmoid | BT549 BX-912 0 1 72 | 8 | 1.839 | 0.909 | 0.247 | 0.157 | 0.742 | 0.24 | 3.23 | 0.992 | 5.95e-07 | NA | 1.2 | 0.419 | 0.872 | 0.698 | 0.415 | 3.25 | 0.988 | 1.54e-06 | NA |
| HCC70 | CAL-101 | 2 | 72 | sigmoid | sigmoid | HCC70 idelalisib 0 2 72 | 8 | 1.738 | Inf | 0.62 | 0.0432 | 0.959 | 0.611 | 3.13 | 0.965 | 4.31e-05 | NA | Inf | 0.693 | 0.965 | 0.935 | 0.686 | 3.13 | 0.96 | 6.52e-05 | NA |
| HCC1806 | BX-912 | 3 | 72 | sigmoid | sigmoid | HCC1806 BX-912 0 3 72 | 8 | 3.193 | 1.09 | 0.234 | 0.126 | 0.897 | 0.217 | 2.99 | 0.999 | 2.85e-09 | NA | 0.894 | 0.214 | 0.853 | 0.753 | 0.205 | 3.07 | 0.997 | 2.86e-08 | NA |
| HCC1806 | BX-912 | 1 | 72 | sigmoid | sigmoid | HCC1806 BX-912 0 1 72 | 8 | 2.740 | 0.971 | 0.14 | 0.143 | 0.885 | 0.121 | 2.99 | 0.998 | 3.45e-09 | NA | 0.894 | 0.214 | 0.853 | 0.753 | 0.205 | 3.07 | 0.997 | 2.86e-08 | NA |
| HCC1806 | BX-912 | 2 | 72 | sigmoid | sigmoid | HCC1806 BX-912 0 2 72 | 8 | 2.825 | 0.992 | 0.159 | 0.14 | 0.888 | 0.141 | 2.99 | 0.999 | 3.32e-09 | NA | 0.894 | 0.214 | 0.854 | 0.753 | 0.205 | 3.07 | 0.997 | 2.86e-08 | NA |
| HCC1806 | Buparlisib | 3 | 72 | sigmoid | sigmoid | HCC1806 buparlisib 0 3 72 | 8 | 3.195 | 0.808 | -0.257 | 0.203 | 0.96 | -0.303 | 2.74 | 1.0 | 2.03e-11 | NA | 0.69 | 0.0423 | 0.803 | 0.674 | 0.033 | 2.99 | 0.999 | 1.17e-09 | NA |
| HCC1806 | Buparlisib | 2 | 72 | sigmoid | sigmoid | HCC1806 buparlisib 0 2 72 | 8 | 2.827 | 0.759 | -0.346 | 0.221 | 0.937 | -0.392 | 2.75 | 1.0 | 2.72e-11 | NA | 0.69 | 0.0423 | 0.803 | 0.674 | 0.033 | 2.99 | 0.999 | 1.17e-09 | NA |
| HCC1806 | Buparlisib | 1 | 72 | sigmoid | sigmoid | HCC1806 buparlisib 0 1 72 | 8 | 2.742 | 0.748 | -0.369 | 0.226 | 0.931 | -0.415 | 2.75 | 1.0 | 2.95e-11 | NA | 0.69 | 0.0423 | 0.803 | 0.674 | 0.033 | 2.99 | 0.999 | 1.17e-09 | NA |