Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-436 | Alvocidib | 0.162293194 | -0.0744 | 0.2528 | 0.1693 | -0.0464 | 2.0866 | 0.9251 | 8.55e-15 |
| SK-BR-3 | Alvocidib | 0.138970351 | -0.7648 | 0.3411 | 0.3016 | -1.0000 | 1.4181 | 0.9513 | 1.11e-16 |
| MCF7 | Alvocidib | -inf | -0.2526 | ||||||
| MDA-MB-361 | Alvocidib | 0.089713792 | -0.4956 | 0.4193 | 0.3494 | -1.0000 | 0.8080 | 0.8065 | 1.21e-09 |
| MDA-MB-468 | Alvocidib | 0.173077952 | -0.4235 | 0.2942 | 0.4622 | -0.9850 | 1.1084 | 0.9659 | 1.11e-16 |
| HCC1937 | Alvocidib | 0.166518918 | -0.2096 | 0.2105 | 0.2327 | -0.3409 | 1.5542 | 0.9076 | 1.17e-13 |
| Hs 578T | Alvocidib | 0.148558558 | -0.2518 | 0.2560 | 0.2079 | -0.3548 | 1.5955 | 0.9912 | 1.11e-16 |
| MCF 10A | Alvocidib | 0.099467899 | -0.4802 | 0.3475 | 0.1398 | -0.5288 | 2.1178 | 0.9920 | 1.11e-16 |
| HCC1428 | Alvocidib | 0.045529066 | -0.8366 | 0.5666 | 0.1496 | -1.0000 | 0.9234 | 0.6998 | 2.94e-07 |
| MDA-MB-157 | Alvocidib | 0.152222738 | -0.8658 | 0.2879 | 0.2794 | -1.0000 | 1.8087 | 0.9385 | 7.77e-16 |
| MDA-MB-453 | Alvocidib | 0.131746612 | -0.1949 | 0.2615 | 0.1512 | -0.1882 | 2.3212 | 0.9251 | 8.55e-15 |
| HCC1500 | Alvocidib | -inf | -0.9990 | ||||||
| AU565 | Alvocidib | 0.087632457 | -0.5502 | 0.3751 | 0.2006 | -0.8064 | 1.1595 | 0.9601 | 1.11e-16 |
| CAL-85-1 | Alvocidib | 0.160024022 | -0.3171 | 0.3835 | 0.1856 | -0.2356 | 2.6082 | 0.7113 | 1.8e-07 |
| HCC1395 | Alvocidib | 0.123109246 | -0.6242 | 0.3359 | 0.3193 | -1.0000 | 1.1526 | 0.9075 | 1.2e-13 |
| HCC38 | Alvocidib | 0.139603749 | -0.4046 | 0.2799 | 0.3955 | -0.9001 | 0.9887 | 0.9746 | 1.11e-16 |
| HCC1419 | Alvocidib | 0.180879399 | -0.2626 | 0.2408 | 0.5478 | -0.8902 | 0.9228 | 0.9420 | 3.33e-16 |
| HME1 | Alvocidib | 0.114196744 | -0.3549 | 0.3125 | 0.4526 | -1.0000 | 0.7978 | 0.9854 | 1.11e-16 |
| HCC1143 | Alvocidib | 0.171201738 | -0.3370 | 0.2245 | 0.2832 | -0.5220 | 1.4205 | 0.9893 | 1.11e-16 |
| CAMA-1 | Alvocidib | 0.174755194 | -0.1534 | 0.2533 | 0.7555 | -1.0000 | 0.7504 | 0.7392 | 5.05e-08 |
| MDA-MB-134-VI | Alvocidib | -inf | -0.4621 | ||||||
| CAL-120 | Alvocidib | -inf | -0.0679 | ||||||
| CAL-51 | Alvocidib | 0.203450964 | -0.1017 | 0.2311 | 0.8363 | -1.0000 | 0.7772 | 0.9758 | 1.11e-16 |
| SUM149PT | Alvocidib | 0.194050461 | -0.4382 | 0.2360 | 0.3478 | -0.7138 | 1.5198 | 0.9775 | 1.11e-16 |
| SUM1315MO2 | Alvocidib | 0.111817025 | -0.7885 | 0.3864 | 0.2928 | -1.0000 | 1.1414 | 0.9268 | 6.44e-15 |