Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| CAL-120 | SHP099 | 13.63352074 | 0.7924 | 0.0042 | 16.9837 | -1.0000 | 5.0000 | 0.4392 | 0.000724955 |
| CAL-85-1 | BMS-265246 | 0.006551436 | -0.0684 | 0.7136 | 8.4904 | -1.0000 | 0.1533 | 0.7672 | 1.22e-08 |
| CAL-51 | RO-3306 | 8.346101408 | 0.1772 | 0.0379 | 11.9039 | -1.0000 | 3.0941 | 0.9243 | 9.77e-15 |
| CAL-85-1 | MK 1775 | 0.182874423 | -0.5298 | 0.5409 | 3.0854 | -1.0000 | 0.3888 | 0.7205 | 1.2e-07 |
| CAL-51 | THZ1 | 0.398213883 | 0.0975 | 0.1363 | 1.3472 | -1.0000 | 0.9014 | 0.9402 | 5.55e-16 |
| CAL-85-1 | AZD6738 | 6.237645512 | 0.1470 | 0.1766 | 11.7933 | -1.0000 | 1.7249 | 0.5594 | 3.56e-05 |
| CAL-51 | Alvocidib | 0.203450964 | -0.1017 | 0.2311 | 0.8363 | -1.0000 | 0.7772 | 0.9758 | 1.11e-16 |
| CAL-51 | MK 1775 | 0.310910353 | -0.1886 | 0.4395 | 4.9452 | -1.0000 | 0.3971 | 0.9792 | 1.11e-16 |
| CAL-51 | LY3023414 | 0.012387901 | -0.1180 | 0.6129 | 29.3234 | -1.0000 | 0.1414 | 0.7984 | 2.03e-09 |
| CAL-120 | RO-3306 | 8.527233934 | 0.1534 | 0.0250 | 10.6226 | -1.0000 | 5.0000 | 0.9423 | 3.33e-16 |
| CAL-51 | AZD2014 | 0.186060272 | 0.1980 | 0.4693 | 322.5046 | -1.0000 | 0.1473 | 0.9177 | 2.79e-14 |
| CAL-51 | Ribociclib | 3.77803891 | 0.3496 | 0.2868 | 766.6836 | -1.0000 | 0.2068 | 0.9334 | 2e-15 |
| AU565 | AZD5363 | 5.62582806 | 0.3226 | 0.2242 | 182.9894 | -1.0000 | 0.3155 | 0.7817 | 5.48e-09 |
| CAL-51 | BMS-265246 | 4.166699159 | 0.3180 | 0.2124 | 83.7459 | -1.0000 | 0.3661 | 0.8327 | 1.96e-10 |
| AU565 | GSK2334470 | 7.667010215 | 0.3822 | 0.2226 | 556.8242 | -1.0000 | 0.2564 | 0.7005 | 2.86e-07 |
| CAL-51 | AZD6738 | 5.499126795 | 0.0467 | 0.0977 | 10.8204 | -1.0000 | 1.6231 | 0.9631 | 1.11e-16 |
| AU565 | AZD6738 | 9.117192222 | 0.2755 | 0.0564 | 11.3576 | -1.0000 | 5.0000 | 0.7383 | 5.27e-08 |
| CAL-120 | AZD5363 | 51.38789856 | 0.7988 | 0.0266 | 243.4579 | -1.0000 | 0.7063 | 0.4791 | 0.0002881 |
| AU565 | LY3023414 | 0.003983539 | -0.4704 | 0.7921 | 0.8999 | -1.0000 | 0.2027 | 0.8707 | 7.87e-12 |
| AU565 | MK 1775 | 0.223405816 | -0.4543 | 0.4894 | 3.6482 | -1.0000 | 0.3933 | 0.8692 | 9.09e-12 |
| CAL-120 | Ulixertinib | 9.575963441 | 0.4271 | 0.1000 | 64.2469 | -1.0000 | 0.5772 | 0.9125 | 5.95e-14 |
| AU565 | RO-3306 | 0.451155856 | -0.1943 | 0.4065 | 23.6830 | -1.0000 | 0.2774 | 0.5910 | 1.4e-05 |
| AU565 | Ulixertinib | 10.84540185 | 0.5262 | 0.0915 | 39.9318 | -1.0000 | 0.8429 | 0.6917 | 4.1e-07 |
| CAL-85-1 | RO-3306 | 6.045627864 | -0.3140 | 0.2213 | 9.4578 | -1.0000 | 2.4550 | 0.5125 | 0.000125886 |
| CAL-85-1 | Ulixertinib | 3.83746694 | 0.2311 | 0.2960 | 72.1557 | -1.0000 | 0.3744 | 0.3008 | 0.011412092 |