Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| HCC1500 | THZ1 | -inf | -0.9999 | ||||||
| HCC1500 | AZD2014 | 1.37e-05 | -0.9997 | 1.9963 | 0.0000 | -0.9980 | 1.4781 | 0.6747 | 8.02e-07 |
| HCC1500 | THZ531 | -inf | -0.9990 | ||||||
| HCC1500 | Alvocidib | -inf | -0.9990 | ||||||
| HCC1500 | LY3023414 | 2.44e-06 | -0.9965 | 1.9835 | 0.0000 | -0.9955 | 0.7773 | 0.6628 | 1.25e-06 |
| HCC1500 | RO-3306 | -inf | -0.9896 | ||||||
| MDA-MB-361 | LY3023414 | 1.3e-05 | -0.9848 | 1.4263 | 0.0014 | -1.0000 | 0.2362 | 0.9070 | 1.28e-13 |
| HCC1500 | Senexin B | -inf | -0.9794 | ||||||
| HCC1500 | MK 1775 | -inf | -0.9646 | ||||||
| HCC1500 | AZD6738 | -inf | -0.9469 | ||||||
| MDA-MB-134-VI | LY3023414 | 2.28e-05 | -0.9131 | 1.4118 | 0.0019 | -1.0000 | 0.2471 | 0.8907 | 9.62e-13 |
| MDA-MB-157 | THZ1 | 0.032181836 | -0.8998 | 0.5842 | 0.0485 | -0.8227 | 2.3777 | 0.9766 | 1.11e-16 |
| HCC1428 | THZ531 | 0.034802646 | -0.8953 | 0.6552 | 0.0565 | -0.7360 | 1.8647 | 0.7050 | 2.36e-07 |
| HCC70 | THZ1 | -inf | -0.8868 | ||||||
| HCC1428 | THZ1 | 0.011292388 | -0.8773 | 0.6550 | 0.0212 | -0.7576 | 1.4635 | 0.8598 | 2.16e-11 |
| MDA-MB-157 | MK 1775 | -inf | -0.8758 | ||||||
| MDA-MB-157 | Alvocidib | 0.152222738 | -0.8658 | 0.2879 | 0.2794 | -1.0000 | 1.8087 | 0.9385 | 7.77e-16 |
| HCC70 | Alvocidib | 0.0750808131344 | -0.8534 | 0.4131 | 0.1347 | -0.9337 | 1.8026 | 0.9849 | 1.11022302463e-16 |
| HCC70 | THZ531 | 0.0645734883647 | -0.8397 | 0.4266 | 0.0849 | -0.7832 | 3.4505 | 0.9663 | 1.11022302463e-16 |
| HCC1428 | Alvocidib | 0.045529066 | -0.8366 | 0.5666 | 0.1496 | -1.0000 | 0.9234 | 0.6998 | 2.94e-07 |
| SUM1315MO2 | Alvocidib | 0.111817025 | -0.7885 | 0.3864 | 0.2928 | -1.0000 | 1.1414 | 0.9268 | 6.44e-15 |
| SK-BR-3 | THZ1 | 0.014309421 | -0.7784 | 0.6625 | 0.0292 | -0.7395 | 1.2733 | 0.9657 | 1.11e-16 |
| SK-BR-3 | Alvocidib | 0.138970351 | -0.7648 | 0.3411 | 0.3016 | -1.0000 | 1.4181 | 0.9513 | 1.11e-16 |
| MDA-MB-157 | THZ531 | 0.060618587 | -0.7599 | 0.4261 | 0.0784 | -0.6567 | 3.2544 | 0.9596 | 1.11e-16 |
| MCF 10A | Alvocidib | -inf | -0.7589 |