Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| HCC1500 | Ribociclib | inf | 1.0336 | 0.4512 | 0.0000 | 0.5131 | 0.0100 | 0.0000 | 1.0 |
| HCC1500 | BMS-265246 | -inf | 0.2444 | 0.9257 | 0.0000 | 0.1272 | 0.0100 | 0.0000 | 1.0 |
| HCC1428 | SHP099 | inf | 0.2659 | 0.1940 | 0.0000 | 0.7961 | 0.0100 | 0.0000 | 0.260975398 |
| HCC1428 | AZD5363 | inf | 1.8797 | -0.1143 | 0.0000 | 1.0000 | 0.0100 | -0.2534 | 1.0 |
| HCC1500 | AZD2014 | 1.37e-05 | -0.9997 | 1.9963 | 0.0000 | -0.9980 | 1.4781 | 0.6747 | 8.02e-07 |
| HCC1428 | Senexin B | -inf | -0.2008 | 0.6803 | 0.0000 | 0.2756 | 0.0100 | 0.0000 | 0.123657155 |
| HCC1428 | AZD6738 | inf | 0.5583 | -0.2743 | 0.0000 | 1.0000 | 0.0100 | -0.1317 | 0.820290357 |
| HCC1419 | Rucaparib | inf | 0.8069 | 0.0539 | 0.0000 | 0.9485 | 0.0100 | 0.0000 | 0.337916631 |
| HCC1419 | SHP099 | inf | 0.7338 | 0.0420 | 0.0000 | 0.9489 | 0.0100 | 0.0000 | 0.203508371 |
| CAL-85-1 | AZD5363 | inf | 0.2770 | 0.1987 | 0.0000 | 0.8552 | 0.0100 | 0.0000 | 0.179970694 |
| HCC1428 | Ribociclib | #NAME? | -0.3849 | 0.7838 | 0.0000 | 0.2963 | 0.0100 | 0.0000 | 0.210923138 |
| CAL-51 | SHP099 | inf | 0.8600 | 0.0220 | 0.0000 | 0.9665 | 0.0100 | 0.0000 | 1.0 |
| AU565 | SHP099 | inf | 0.9751 | 0.0242 | 0.0000 | 0.9633 | 0.0100 | 0.0000 | 1.0 |
| CAL-85-1 | GSK2334470 | inf | 0.1906 | 0.2483 | 0.0000 | 0.7764 | 0.0100 | 0.0000 | 0.11208861 |
| CAMA-1 | SHP099 | inf | 0.6544 | 0.0867 | 0.0000 | 0.9242 | 0.0100 | 0.0000 | 0.798838019 |
| CAL-85-1 | Ribociclib | inf | 0.9479 | 0.1502 | 0.0000 | 0.8929 | 0.0100 | 0.0000 | 1.0 |
| CAL-85-1 | Senexin B | inf | 0.7288 | 0.3316 | 0.0000 | 0.7468 | 0.0100 | 0.0000 | 0.98409231 |
| CAMA-1 | GSK2334470 | inf | 0.6437 | -0.0125 | 0.0000 | 0.9959 | 0.0100 | 0.0000 | 0.05607765 |
| CAL-120 | AZD6738 | inf | 0.7588 | -0.1771 | 0.0000 | 1.0000 | 0.0100 | -1.1414 | 0.170552683 |
| CAL-85-1 | SHP099 | inf | 0.5820 | 0.2604 | 0.0000 | 0.8282 | 0.0100 | 0.0000 | 1.0 |
| CAL-120 | Senexin B | inf | 0.8437 | 0.1267 | 0.0000 | 0.8683 | 0.0100 | 0.0000 | 0.139800748 |
| AU565 | Senexin B | inf | 0.8184 | 0.1417 | 0.0000 | 0.8787 | 0.0100 | 0.0000 | 0.163234872 |
| AU565 | Rucaparib | inf | 0.6448 | 0.1041 | 0.0000 | 0.9100 | 0.0100 | 0.0000 | 0.204759045 |
| HCC1500 | Rucaparib | #NAME? | 1.0742 | 0.0000 | 0.1000 | 0.0100 | |||
| HCC1500 | LY3023414 | 2.44e-06 | -0.9965 | 1.9835 | 0.0000 | -0.9955 | 0.7773 | 0.6628 | 1.25e-06 |