Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| AU565 | MK 1775 | 0.223405816 | -0.4543 | 0.4894 | 3.6482 | -1.0000 | 0.3933 | 0.8692 | 9.09e-12 |
| AU565 | AZD2014 | 0.003613668 | 0.0045 | 0.7508 | 0.0061 | -0.0974 | 0.3356 | 0.9277 | 5.44e-15 |
| AU565 | AZD5363 | 5.62582806 | 0.3226 | 0.2242 | 182.9894 | -1.0000 | 0.3155 | 0.7817 | 5.48e-09 |
| AU565 | AZD6738 | 9.117192222 | 0.2755 | 0.0564 | 11.3576 | -1.0000 | 5.0000 | 0.7383 | 5.27e-08 |
| AU565 | BMS-265246 | 0.295937858 | -0.1432 | 0.5304 | 0.7056 | -0.3746 | 0.6436 | 0.6685 | 1.01e-06 |
| AU565 | Ulixertinib | 10.84540185 | 0.5262 | 0.0915 | 39.9318 | -1.0000 | 0.8429 | 0.6917 | 4.1e-07 |
| AU565 | Alvocidib | 0.087632457 | -0.5502 | 0.3751 | 0.2006 | -0.8064 | 1.1595 | 0.9601 | 1.11e-16 |
| AU565 | GSK2334470 | 7.667010215 | 0.3822 | 0.2226 | 556.8242 | -1.0000 | 0.2564 | 0.7005 | 2.86e-07 |
| AU565 | Ribociclib | 0.595293001 | 0.2313 | 0.4319 | 179.3835 | -0.8827 | 0.1782 | 0.7890 | 3.57e-09 |
| AU565 | LY3023414 | 0.003983539 | -0.4704 | 0.7921 | 0.8999 | -1.0000 | 0.2027 | 0.8707 | 7.87e-12 |
| AU565 | RO-3306 | 0.451155856 | -0.1943 | 0.4065 | 23.6830 | -1.0000 | 0.2774 | 0.5910 | 1.4e-05 |
| AU565 | Rucaparib | inf | 0.6448 | 0.1041 | 0.0000 | 0.9100 | 0.0100 | 0.0000 | 0.204759045 |
| AU565 | Senexin B | inf | 0.8184 | 0.1417 | 0.0000 | 0.8787 | 0.0100 | 0.0000 | 0.163234872 |
| AU565 | SHP099 | inf | 0.9751 | 0.0242 | 0.0000 | 0.9633 | 0.0100 | 0.0000 | 1.0 |
| AU565 | THZ1 | 0.018314242 | -0.5809 | 0.5779 | 0.0306 | -0.5110 | 1.3730 | 0.9728 | 1.11e-16 |
| AU565 | THZ531 | 0.054699066 | -0.4980 | 0.4261 | 0.0769 | -0.4380 | 1.8479 | 0.9799 | 1.11e-16 |
| CAL-120 | MK 1775 | 0.196043462 | -0.2603 | 0.4877 | 0.9132 | -0.5740 | 0.4969 | 0.9800 | 1.11e-16 |
| CAL-120 | AZD2014 | 0.180566054 | 0.2238 | 0.4601 | 0.3048 | -0.0864 | 0.3044 | 0.9313 | 2.89e-15 |
| CAL-120 | AZD5363 | 51.38789856 | 0.7988 | 0.0266 | 243.4579 | -1.0000 | 0.7063 | 0.4791 | 0.0002881 |
| CAL-120 | AZD6738 | inf | 0.7588 | -0.1771 | 0.0000 | 1.0000 | 0.0100 | -1.1414 | 0.170552683 |
| CAL-120 | BMS-265246 | 2.125230074 | 0.3446 | 0.3401 | 1000.0000 | -0.9133 | 0.1688 | 0.8479 | 6e-11 |
| CAL-120 | Ulixertinib | 9.575963441 | 0.4271 | 0.1000 | 64.2469 | -1.0000 | 0.5772 | 0.9125 | 5.95e-14 |
| CAL-120 | Alvocidib | -inf | -0.0679 | ||||||
| CAL-120 | GSK2334470 | 4306.150401 | 0.7693 | 0.0812 | 1000.0000 | 0.1525 | 0.2492 | 0.4548 | 0.000509344 |
| CAL-120 | Ribociclib | inf | 0.6501 | 0.2665 | 0.0400 | 0.5150 | 0.2263 | 0.7456 | 3.71e-08 |