Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)

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Cell Small Molecule GR50 GRmax GR_AOC GEC50 GRinf GR Hill Coefficient GR r2 pval_GR
AU565 MK 1775
0.223405816
-0.4543 0.4894 3.6482 -1.0000 0.3933 0.8692
9.09e-12
AU565 AZD2014
0.003613668
0.0045 0.7508 0.0061 -0.0974 0.3356 0.9277
5.44e-15
AU565 AZD5363
5.62582806
0.3226 0.2242 182.9894 -1.0000 0.3155 0.7817
5.48e-09
AU565 AZD6738
9.117192222
0.2755 0.0564 11.3576 -1.0000 5.0000 0.7383
5.27e-08
AU565 BMS-265246
0.295937858
-0.1432 0.5304 0.7056 -0.3746 0.6436 0.6685
1.01e-06
AU565 Ulixertinib
10.84540185
0.5262 0.0915 39.9318 -1.0000 0.8429 0.6917
4.1e-07
AU565 Alvocidib
0.087632457
-0.5502 0.3751 0.2006 -0.8064 1.1595 0.9601
1.11e-16
AU565 GSK2334470
7.667010215
0.3822 0.2226 556.8242 -1.0000 0.2564 0.7005
2.86e-07
AU565 Ribociclib
0.595293001
0.2313 0.4319 179.3835 -0.8827 0.1782 0.7890
3.57e-09
AU565 LY3023414
0.003983539
-0.4704 0.7921 0.8999 -1.0000 0.2027 0.8707
7.87e-12
AU565 RO-3306
0.451155856
-0.1943 0.4065 23.6830 -1.0000 0.2774 0.5910
1.4e-05
AU565 Rucaparib
inf
0.6448 0.1041 0.0000 0.9100 0.0100 0.0000
0.204759045
AU565 Senexin B
inf
0.8184 0.1417 0.0000 0.8787 0.0100 0.0000
0.163234872
AU565 SHP099
inf
0.9751 0.0242 0.0000 0.9633 0.0100 0.0000
1.0
AU565 THZ1
0.018314242
-0.5809 0.5779 0.0306 -0.5110 1.3730 0.9728
1.11e-16
AU565 THZ531
0.054699066
-0.4980 0.4261 0.0769 -0.4380 1.8479 0.9799
1.11e-16
CAL-120 MK 1775
0.196043462
-0.2603 0.4877 0.9132 -0.5740 0.4969 0.9800
1.11e-16
CAL-120 AZD2014
0.180566054
0.2238 0.4601 0.3048 -0.0864 0.3044 0.9313
2.89e-15
CAL-120 AZD5363
51.38789856
0.7988 0.0266 243.4579 -1.0000 0.7063 0.4791
0.0002881
CAL-120 AZD6738
inf
0.7588 -0.1771 0.0000 1.0000 0.0100 -1.1414
0.170552683
CAL-120 BMS-265246
2.125230074
0.3446 0.3401 1000.0000 -0.9133 0.1688 0.8479
6e-11
CAL-120 Ulixertinib
9.575963441
0.4271 0.1000 64.2469 -1.0000 0.5772 0.9125
5.95e-14
CAL-120 Alvocidib
-inf
-0.0679
CAL-120 GSK2334470
4306.150401
0.7693 0.0812 1000.0000 0.1525 0.2492 0.4548
0.000509344
CAL-120 Ribociclib
inf
0.6501 0.2665 0.0400 0.5150 0.2263 0.7456
3.71e-08
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