Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | AZD6738 | inf | 0.5583 | -0.2743 | 0.0000 | 1.0000 | 0.0100 | -0.1317 | 0.820290357 |
| MDA-MB-157 | AZD6738 | 8.215702739 | -0.0514 | -0.2134 | 10.2346 | -1.0000 | 5.0000 | 0.3830 | 0.000671245 |
| T47D | AZD6738 | inf | 0.6619 | -0.2131 | 0.0000 | 1.0000 | 0.0100 | -0.9822 | 0.211726496 |
| CAL-120 | AZD6738 | inf | 0.7588 | -0.1771 | 0.0000 | 1.0000 | 0.0100 | -1.1414 | 0.170552683 |
| HCC1428 | AZD5363 | inf | 1.8797 | -0.1143 | 0.0000 | 1.0000 | 0.0100 | -0.2534 | 1.0 |
| HCC1937 | AZD6738 | 7.75547782 | 0.2590 | -0.1086 | 19.3707 | -0.9926 | 1.1948 | 0.4429 | 0.00046323 |
| BT-20 | AZD6738 | 5.68190940846 | 0.1069 | -0.0571 | 5.4098 | 0.1088 | 5.0000 | 0.8298 | 2.43821740575e-10 |
| HCC70 | Rucaparib | inf | 1.1144 | -0.0414 | 0.0000 | 1.0000 | 0.0100 | -0.1078 | 1.0 |
| MDA-MB-231 | AZD6738 | 8.82761747838 | 0.3448 | -0.0384 | 12.4996 | -0.9998 | 3.1583 | 0.8459 | 7.04556413211e-11 |
| MCF 10A | Senexin B | 13.2364754711 | 0.8231 | -0.0310 | 16.5655 | -1.0000 | 4.8970 | 0.5533 | 1.42287035656e-05 |
| SUM149PT | SHP099 | 31.82140091 | 0.7648 | -0.0244 | 70.8992 | -0.9990 | 1.3705 | 0.2286 | 0.038994512 |
| CAMA-1 | AZD6738 | 8.908669378 | 0.2804 | -0.0237 | 11.1124 | -1.0000 | 4.9704 | 0.6787 | 6.86e-07 |
| HCC1954 | AZD6738 | 5.21852308366 | 0.1138 | -0.0199 | 5.0338 | 0.0824 | 5.0000 | 0.8519 | 4.27073931775e-11 |
| MDA-MB-231 | AZD5363 | inf | 1.0802 | -0.0194 | 0.0000 | 1.0000 | 0.0100 | -0.2298 | 1.0 |
| MDA-MB-436 | SHP099 | inf | 0.8419 | -0.0182 | 0.0000 | 0.9962 | 0.0100 | 0.0000 | 0.527646554 |
| MDA-MB-231 | SHP099 | inf | 0.9470 | -0.0146 | 0.0000 | 1.0000 | 0.0100 | -0.0002 | 0.198394332856 |
| HCC1937 | Ribociclib | inf | 0.9905 | -0.0141 | 0.0000 | 0.9898 | 0.0100 | 0.0000 | 1.0 |
| MCF 10A | GSK2334470 | 15.0731115613 | 0.8830 | -0.0129 | 18.7770 | -1.0000 | 5.0000 | 0.4636 | 0.000172093714918 |
| CAMA-1 | GSK2334470 | inf | 0.6437 | -0.0125 | 0.0000 | 0.9959 | 0.0100 | 0.0000 | 0.05607765 |
| MDA-MB-436 | Ribociclib | inf | 0.9493 | -0.0090 | 0.0000 | 1.0000 | 0.0100 | -0.0149 | 0.928505437 |
| HCC1806 | SHP099 | inf | 0.9525 | -0.0087 | 0.0000 | 1.0000 | 0.0100 | -0.0671 | 0.950463130981 |
| MDA-MB-231 | RO-3306 | 8.57955379445 | 0.0936 | -0.0084 | 10.6878 | -1.0000 | 5.0000 | 0.9180 | 2.64233079861e-14 |
| T47D | SHP099 | inf | 0.6931 | -0.0080 | 0.0000 | 0.9839 | 0.0100 | 0.0000 | 0.180531821 |
| SUM159PT | AZD6738 | 10.0174126 | 0.4273 | -0.0067 | 12.5628 | -1.0000 | 4.8522 | 0.9120 | 6.41e-14 |
| HCC70 | Ribociclib | inf | 1.0564 | -0.0040 | 0.0000 | 1.0000 | 0.0100 | -0.1699 | 1.0 |