Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| HCC1500 | AZD2014 | 1.37e-05 | -0.9997 | 1.9963 | 0.0000 | -0.9980 | 1.4781 | 0.6747 | 8.02e-07 |
| HCC1500 | LY3023414 | 2.44e-06 | -0.9965 | 1.9835 | 0.0000 | -0.9955 | 0.7773 | 0.6628 | 1.25e-06 |
| MDA-MB-361 | LY3023414 | 1.3e-05 | -0.9848 | 1.4263 | 0.0014 | -1.0000 | 0.2362 | 0.9070 | 1.28e-13 |
| MDA-MB-134-VI | LY3023414 | 2.28e-05 | -0.9131 | 1.4118 | 0.0019 | -1.0000 | 0.2471 | 0.8907 | 9.62e-13 |
| HCC1428 | LY3023414 | 4.66e-07 | -0.7374 | 1.2208 | 0.0032 | -1.0000 | 0.1242 | 0.3630 | 0.003559188 |
| HCC1428 | AZD2014 | 2.19e-05 | -0.5555 | 1.2048 | 0.0005 | -0.5838 | 0.2503 | 0.4940 | 0.000200146 |
| MDA-MB-361 | AZD2014 | 0.000105775 | -0.6868 | 1.1635 | 0.0173 | -1.0000 | 0.2155 | 0.9146 | 4.4e-14 |
| HCC70 | MK 1775 | 0.000494343213706 | -0.7213 | 1.1390 | 0.0113 | -0.7848 | 0.3020 | 0.9292 | 4.21884749358e-15 |
| SUM1315MO2 | MK 1775 | 0.00109721 | -0.6828 | 0.9928 | 0.0075 | -0.4794 | 0.3502 | 0.6449 | 2.4e-06 |
| T47D | AZD2014 | 3.57e-05 | -0.0845 | 0.9793 | 0.0001 | -0.1251 | 0.2870 | 0.8093 | 1.01e-09 |
| HCC1419 | AZD2014 | 0.000451019 | -0.1328 | 0.9581 | 0.0009 | -0.1553 | 0.4080 | 0.8343 | 1.75e-10 |
| HCC1428 | BMS-265246 | 0.000203941 | -0.4531 | 0.9502 | 0.0775 | -0.8101 | 0.1622 | 0.3392 | 0.00563904 |
| BT-549 | BMS-265246 | 0.000876906453272 | -0.1682 | 0.9458 | 0.0017 | -0.1811 | 0.4642 | 0.9714 | 1.11022302463e-16 |
| CAMA-1 | LY3023414 | 4.27e-05 | -0.5001 | 0.9375 | 0.0004 | -0.2985 | 0.2143 | 0.5057 | 0.00014946 |
| HCC38 | MK 1775 | 0.004188304 | -0.4069 | 0.9360 | 0.0178 | -0.4523 | 0.4447 | 0.9813 | 1.11e-16 |
| HCC1500 | BMS-265246 | -inf | 0.2444 | 0.9257 | 0.0000 | 0.1272 | 0.0100 | 0.0000 | 1.0 |
| HCC1937 | BMS-265246 | 0.000340758 | -0.0634 | 0.9143 | 0.0005 | -0.0734 | 0.4108 | 0.8462 | 6.89e-11 |
| HCC70 | BMS-265246 | 0.00319357669583 | -0.1940 | 0.9108 | 0.0045 | -0.1529 | 0.7677 | 0.9705 | 1.11022302463e-16 |
| MDA-MB-157 | BMS-265246 | 0.001094371 | -0.2133 | 0.9099 | 0.0034 | -0.2455 | 0.3568 | 0.8223 | 4.17e-10 |
| T47D | LY3023414 | 0.000116934 | -0.3084 | 0.9068 | 0.4558 | -1.0000 | 0.1329 | 0.9366 | 1.11e-15 |
| MDA-MB-361 | MK 1775 | 0.005155215 | -0.3351 | 0.8878 | 0.0200 | -0.3972 | 0.4315 | 0.8532 | 3.83e-11 |
| CAMA-1 | AZD2014 | 4.02e-06 | -0.0824 | 0.8730 | 0.0055 | -0.5291 | 0.1000 | 0.5846 | 1.7e-05 |
| SK-BR-3 | AZD2014 | 1.21e-05 | -0.0787 | 0.8687 | 0.0006 | -0.3127 | 0.1272 | 0.7038 | 2.48e-07 |
| MDA-MB-453 | LY3023414 | 0.000358181 | -0.6542 | 0.8640 | 0.5638 | -1.0000 | 0.1492 | 0.6094 | 7.89e-06 |
| HME1 | BMS-265246 | 0.001224504 | 0.0652 | 0.8579 | 0.0014 | -0.0301 | 0.4949 | 0.9271 | 6.11e-15 |