MK 1775 - Small Molecule (ID:10152-101)

HMS LINCS ID: 10152-101
Name: MK 1775
Alternative Names:
LINCS ID: LSM-1153
PubChem CID: 24856436
ChEBI ID:
ChEMBL ID:
Molecular Mass: 500.26
InChi: InChI=1S/C27H32N8O2/c1-5-13-34-25(36)21-18-28-26(29-19-9-11-20(12-10-19)33-16-14-32(4)15-17-33)31-24(21)35(34)23-8-6-7-22(30-23)27(2,3)37/h5-12,18,37H,1,13-17H2,2-4H3,(H,28,29,31)
InChi Key: BKWJAKQVGHWELA-UHFFFAOYSA-N
SMILES: CC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC=C(C=C4)N5CCN(CC5)C)O
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
2
(equivalent to 100 nM ≤ Kd < 1µM)
ABL1, CDK5, LCK, LRRK2, NEK2, PRKCQ, SYK, TNK2, WEE1
3
(equivalent to 1µM ≤ Kd < 10 µM)
ACVR1, AIM1, ALK, AURKB, BTK, CAMK1D, CAMK2A, CDK7, CDK8, CHEK1, CLK2, CLK4, CSF1R, CSNK1A1, DAPK3, DYRK1B, FGFR1, FGFR3, FLG, FLT1, FLT3, FYN, GRK5, GSK3A, GSK3B, IGF1R, IKBKE, JAK2, JAK3, LIMK1, LTK, MAP2K1, MAP2K2, MAP4K2, MAP4K4, MAP4K5, MAPK14, MAPK8, MAPK9, MET, MINK1, MST1R, NTRK1, NTRK2, NTRK3, PAK4, PDGFRA, PIM1, PKN2, PRKAA1, PRKD3, PRKX, PTK2, RET, ROCK1, ROS1, RPS6KA3, STK3, TAOK1, TBK1, TYRO3
10
(confirmed non-binding)

Batch Information for HMSL10152-101-2:

HMS LINCS Batch ID: 10152-101-2
Provider: MedChem Express
Provider Batch ID: 03485
Salt: 101
Molecular Formula: C27H32N8O2
Molecular Weight: 500.6
Purity:
Purification Method:
Chemical Synthesis Reference:
Comments:
Date Publicly Available: 2015-06-17
Most Recent Update: 2016-04-04

HMS QC Testing Events for HMSL10152-101-2:

Date HMS QC Outcome Comment Files
08/31/2015 PASS HMSL10152-101-2_LCMS.pdf