Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | Ulixertinib | 0.487697861 | 0.0501 | 0.2106 | 0.3084 | 0.4494 | 5.0000 | 0.6060 | 8.79e-06 |
| SK-BR-3 | Ulixertinib | 6.689869543 | 0.1867 | 0.1225 | 26.0072 | -1.0000 | 0.8091 | 0.7440 | 4.01e-08 |
| HME1 | Ulixertinib | 0.212403292 | -0.0098 | 0.4485 | 0.3361 | -0.1385 | 0.5327 | 0.9448 | 2.22e-16 |
| MDA-MB-157 | Ulixertinib | -inf | 0.3233 | ||||||
| MDA-MB-453 | Ulixertinib | 7.626205493 | 0.3905 | 0.0734 | 22.8576 | -1.0000 | 1.0008 | 0.7623 | 1.58e-08 |
| MDA-MB-468 | Ulixertinib | 1.621194239 | 0.3429 | 0.2660 | 0.2539 | 0.3452 | 0.6324 | 0.9377 | 8.88e-16 |
| HCC38 | Ulixertinib | 4.626845935 | 0.3500 | 0.2125 | 206.4527 | -1.0000 | 0.2892 | 0.7494 | 3.07e-08 |
| Hs 578T | Ulixertinib | 1.12758771 | 0.2421 | 0.3284 | 1.7251 | -0.0883 | 0.3825 | 0.9567 | 1.11e-16 |
| MCF7 | Ulixertinib | 3.786667089 | 0.3222 | 0.1986 | 9.6095 | -0.2846 | 0.4838 | 0.8626 | 1.69e-11 |
| MDA-MB-134-VI | Ulixertinib | -inf | -0.2948 | ||||||
| MDA-MB-436 | Ulixertinib | 34.76507133 | 0.5719 | 0.1213 | 534.6670 | -1.0000 | 0.4020 | 0.5984 | 1.11e-05 |
| CAMA-1 | Ulixertinib | 2.566161953 | 0.1288 | 0.2586 | 42.4009 | -1.0000 | 0.3917 | 0.5616 | 3.34e-05 |
| HCC1419 | Ulixertinib | 15.03549958 | 0.5776 | 0.0806 | 48.1146 | -1.0000 | 0.9445 | 0.5529 | 4.27e-05 |
| HCC1937 | Ulixertinib | 15.02907863 | 0.4534 | 0.1152 | 180.4631 | -1.0000 | 0.4420 | 0.6441 | 2.46e-06 |
| HCC1500 | Ulixertinib | -inf | 0.3396 | ||||||
| CAL-51 | Ulixertinib | 20.08181132 | 0.7439 | 0.0569 | 48.1868 | -0.9997 | 1.2549 | 0.4674 | 0.000380369 |
| CAL-85-1 | Ulixertinib | 3.83746694 | 0.2311 | 0.2960 | 72.1557 | -1.0000 | 0.3744 | 0.3008 | 0.011412092 |
| HCC1143 | Ulixertinib | 1.718095034 | 0.0344 | 0.2458 | 19.1869 | -1.0000 | 0.4553 | 0.8884 | 1.25e-12 |
| HCC1395 | Ulixertinib | 1.871580782 | 0.1659 | 0.2498 | 4.1054 | -0.2114 | 0.4489 | 0.7753 | 7.87e-09 |
| MCF 10A | Ulixertinib | 1.461707314 | 0.2159 | 0.2704 | 2.7171 | -0.1676 | 0.4662 | 0.9511 | 1.11e-16 |
| CAL-120 | Ulixertinib | 9.575963441 | 0.4271 | 0.1000 | 64.2469 | -1.0000 | 0.5772 | 0.9125 | 5.95e-14 |
| HCC1428 | Ulixertinib | 0.227625258 | 0.1375 | 0.4320 | 0.1734 | 0.1614 | 1.4315 | 0.2319 | 0.036949884 |
| AU565 | Ulixertinib | 10.84540185 | 0.5262 | 0.0915 | 39.9318 | -1.0000 | 0.8429 | 0.6917 | 4.1e-07 |
| SUM149PT | Ulixertinib | 2.037761408 | 0.1734 | 0.2350 | 4.8956 | -0.2916 | 0.5241 | 0.9161 | 3.52e-14 |
| SUM1315MO2 | Ulixertinib | 5.524882323 | 0.1115 | 0.1198 | 15.1090 | -1.0000 | 1.0920 | 0.7778 | 6.82e-09 |