Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| MCF7 | GSK2334470 | 3.397326315 | 0.2955 | 0.2507 | 120.0410 | -1.0000 | 0.3082 | 0.7269 | 9e-08 |
| MCF 10A | AZD5363 | 61.7286667806 | 0.7916 | 0.0307 | 77.1806 | -0.0911 | 0.7489 | 0.9088 | 9.96980276113e-14 |
| CAL-51 | RO-3306 | 8.346101408 | 0.1772 | 0.0379 | 11.9039 | -1.0000 | 3.0941 | 0.9243 | 9.77e-15 |
| MDA-MB-134-VI | LY3023414 | 2.28e-05 | -0.9131 | 1.4118 | 0.0019 | -1.0000 | 0.2471 | 0.8907 | 9.62e-13 |
| BT-20 | Ulixertinib | 11.8069404762 | 0.3655 | 0.1384 | 160.1062 | -1.0000 | 0.4214 | 0.7256 | 9.53864038866e-08 |
| HCC70 | AZD2014 | 0.000212092429893 | 0.0222 | 0.7748 | 0.0025 | -0.2340 | 0.1552 | 0.8423 | 9.37158128878e-11 |
| SUM1315MO2 | LY3023414 | 0.016412717 | -0.2854 | 0.6641 | 4.0058 | -1.0000 | 0.1998 | 0.8425 | 9.21e-11 |
| AU565 | MK 1775 | 0.223405816 | -0.4543 | 0.4894 | 3.6482 | -1.0000 | 0.3933 | 0.8692 | 9.09e-12 |
| MCF7 | Ribociclib | 0.189284804 | 0.2285 | 0.4067 | 0.0345 | 0.2453 | 0.3959 | 0.8429 | 8.95e-11 |
| MDA-MB-468 | Ulixertinib | 1.621194239 | 0.3429 | 0.2660 | 0.2539 | 0.3452 | 0.6324 | 0.9377 | 8.88e-16 |
| MDA-MB-231 | AZD2014 | 0.54209289151 | 0.2201 | 0.4003 | 113.8476 | -1.0000 | 0.2055 | 0.9249 | 8.881784197e-15 |
| MDA-MB-361 | Ulixertinib | 0.487697861 | 0.0501 | 0.2106 | 0.3084 | 0.4494 | 5.0000 | 0.6060 | 8.79e-06 |
| MDA-MB-453 | Alvocidib | 0.131746612 | -0.1949 | 0.2615 | 0.1512 | -0.1882 | 2.3212 | 0.9251 | 8.55e-15 |
| MDA-MB-436 | Alvocidib | 0.162293194 | -0.0744 | 0.2528 | 0.1693 | -0.0464 | 2.0866 | 0.9251 | 8.55e-15 |
| SUM159PT | THZ531 | 1.158729591 | 0.6103 | 0.0475 | 1.7617 | -1.0000 | 2.6222 | 0.8700 | 8.37e-12 |
| BT-20 | THZ531 | 1.39952715577 | 0.5663 | 0.0377 | 3.3807 | -1.0000 | 1.2457 | 0.6737 | 8.31588281125e-07 |
| MCF 10A | Senexin B | 617.6674136 | 0.8672 | 0.0282 | 1000.0000 | -0.1291 | 0.4768 | 0.7287 | 8.28e-08 |
| HCC1954 | Ulixertinib | 2.75874205583 | 0.2574 | 0.2843 | 57.3582 | -1.0000 | 0.3620 | 0.7744 | 8.25544232974e-09 |
| MDA-MB-157 | LY3023414 | 0.120671918 | -0.4605 | 0.5635 | 2.6226 | -1.0000 | 0.3568 | 0.8702 | 8.21e-12 |
| MDA-MB-134-VI | MK 1775 | 0.087205685 | -0.3434 | 0.5624 | 3.0209 | -1.0000 | 0.3099 | 0.7289 | 8.21e-08 |
| HCC1937 | LY3023414 | 0.148759974 | -0.0889 | 0.4702 | 448.2987 | -1.0000 | 0.1371 | 0.5290 | 8.17e-05 |
| HCC1806 | LY3023414 | 0.347508533485 | -0.0312 | 0.4262 | 128.5881 | -1.0000 | 0.1858 | 0.6743 | 8.14403017468e-07 |
| HCC1500 | AZD2014 | 1.37e-05 | -0.9997 | 1.9963 | 0.0000 | -0.9980 | 1.4781 | 0.6747 | 8.02e-07 |
| HCC38 | AZD2014 | 0.444460248 | 0.1801 | 0.4094 | 63.7169 | -1.0000 | 0.2213 | 0.8924 | 7.9e-13 |
| MDA-MB-453 | LY3023414 | 0.000358181 | -0.6542 | 0.8640 | 0.5638 | -1.0000 | 0.1492 | 0.6094 | 7.89e-06 |