Evaluation of the sensitivity of two triple-negative breast cancer cell lines (HCC1806, HCC70) to a collection of dual mTOR and PI3K-like kinase (PIKK) inhibitors. Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivity of two triple-negative breast cancer cell lines (HCC1806, HCC70) to a collection of dual mTOR and PI3K-like kinase (PIKK) inhibitors. Dataset 2 of 2: GR metrics. - Dataset (ID:20367)

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Cell line	Drug name	Experimental replicate	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared curve fit (GR values)	P-value curve fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared curve fit (relative cell counts)	P-value curve fit (relative cell counts)
HCC70	AZD8055	1	sigmoid	sigmoid	HCC70 AZD8055 0 1	9	1.598	0.0382	0.0624	0.564	0.0292	0.0882	0.722	0.969	1.75e-26	0.158	0.364	0.601	0.0229	0.379	0.734	0.965	1.44e-25
HCC70	AZD8055	2	sigmoid	sigmoid	HCC70 AZD8055 0 2	9	1.573	0.029	-0.0375	0.612	0.0272	0.0241	0.792	0.972	3.37e-27	0.0959	0.317	0.576	0.0216	0.35	0.808	0.974	9.92e-28
HCC70	AZD8055	3	sigmoid	sigmoid	HCC70 AZD8055 0 3	9	1.750	0.0456	0.0533	0.54	0.0343	0.105	0.837	0.979	2.64e-29	0.109	0.326	0.593	0.026	0.359	0.885	0.98	1.62e-29
HCC70	QL-IV-100	1	sigmoid	sigmoid	HCC70 QL-IV-100 0 1	9	1.598	0.115	-0.713	0.67	0.502	-0.951	0.723	0.992	2.58e-36	0.219	0.045	0.574	0.219	0.0	0.776	0.989	2.4e-34
HCC70	QL-IV-100	2	sigmoid	sigmoid	HCC70 QL-IV-100 0 2	9	1.573	0.0891	-0.75	0.716	0.451	-1.0	0.678	0.986	2.16e-32	0.18	0.0381	0.549	0.18	0.0	0.729	0.977	1.02e-28
HCC70	QL-IV-100	3	sigmoid	sigmoid	HCC70 QL-IV-100 0 3	9	1.750	0.129	-0.657	0.638	0.443	-0.822	0.786	0.989	2.41e-34	0.208	0.0458	0.575	0.208	0.0	0.819	0.985	1.33e-31
HCC70	QL-V-107	1	sigmoid	sigmoid	HCC70 QL-V-107 0 1	9	1.598	0.0994	-0.612	0.672	0.409	-0.834	0.694	0.988	3.47e-33	0.206	0.0727	0.566	0.206	0.0	0.712	0.984	4.79e-31
HCC70	QL-V-107	2	sigmoid	sigmoid	HCC70 QL-V-107 0 2	9	1.573	0.0752	-0.655	0.721	0.361	-0.895	0.653	0.99	7.55e-35	0.163	0.0632	0.541	0.163	0.0	0.682	0.987	1.08e-32
HCC70	QL-V-107	3	sigmoid	sigmoid	HCC70 QL-V-107 0 3	9	1.750	0.14	-0.593	0.616	0.414	-0.728	0.829	0.994	4.36e-39	0.227	0.0616	0.585	0.222	0.0103	0.847	0.991	1.33e-35
HCC70	QL-V-73	1	sigmoid	sigmoid	HCC70 QL-V-73 0 1	9	1.598	0.538	-0.558	0.42	2.22	-1.0	0.774	0.987	5.03e-33	0.973	0.0898	0.716	0.973	0.0	0.812	0.98	1.98e-29
HCC70	QL-V-73	2	sigmoid	sigmoid	HCC70 QL-V-73 0 2	9	1.573	0.397	-0.619	0.474	1.71	-1.0	0.751	0.983	7.11e-31	0.749	0.0739	0.686	0.749	0.0	0.776	0.972	4.32e-27
HCC70	QL-V-73	3	sigmoid	sigmoid	HCC70 QL-V-73 0 3	9	1.750	0.729	-0.527	0.364	2.62	-1.0	0.859	0.991	2.06e-35	1.08	0.0803	0.743	1.08	0.0	0.961	0.983	6.66e-31
HCC70	QL-VI-86	1	sigmoid	sigmoid	HCC70 QL-VI-86 0 1	9	1.598	0.299	-0.674	0.511	1.21	-1.0	0.786	0.987	7.69e-33	0.529	0.0552	0.668	0.529	0.0	0.854	0.981	5.86e-30
HCC70	QL-VI-86	2	sigmoid	sigmoid	HCC70 QL-VI-86 0 2	9	1.573	0.266	-0.695	0.519	0.899	-0.926	0.861	0.989	1.06e-33	0.467	0.052	0.672	0.467	0.0	0.934	0.983	9.31e-31
HCC70	QL-VI-86	3	sigmoid	sigmoid	HCC70 QL-VI-86 0 3	9	1.750	0.305	-0.639	0.508	1.34	-1.0	0.742	0.989	4.41e-34	0.478	0.0501	0.649	0.478	0.0	0.81	0.981	5.26e-30
HCC70	QL-VIII-58	1	sigmoid	sigmoid	HCC70 QL-VIII-58 0 1	9	1.598	0.0739	-0.976	0.791	0.319	-1.0	0.752	0.972	4.08e-27	0.127	0.000989	0.519	0.127	0.0	0.723	0.981	6.68e-30
HCC70	QL-VIII-58	2	sigmoid	sigmoid	HCC70 QL-VIII-58 0 2	9	1.573	0.0674	-0.973	0.806	0.287	-1.0	0.759	0.972	3.07e-27	0.12	0.00122	0.517	0.12	0.0	0.752	0.975	6.9e-28
HCC70	QL-VIII-58	3	sigmoid	sigmoid	HCC70 QL-VIII-58 0 3	9	1.750	0.0774	-0.942	0.769	0.364	-1.0	0.709	0.974	1.07e-27	0.115	0.00207	0.506	0.115	0.0	0.688	0.979	3.76e-29
HCC70	QL-X-138	1	sigmoid	sigmoid	HCC70 QL-X-138 0 1	9	1.598	1.41	-0.213	0.248	3.83	-0.724	0.893	0.983	5.84e-31	2.51	0.225	0.827	2.38	0.025	0.931	0.978	8.59e-29
HCC70	QL-X-138	2	sigmoid	sigmoid	HCC70 QL-X-138 0 2	9	1.573	1.62	-0.286	0.211	3.74	-0.725	1.07	0.966	1.18e-25	2.65	0.198	0.859	2.44	0.045	1.14	0.953	3.05e-23
HCC70	QL-X-138	3	sigmoid	sigmoid	HCC70 QL-X-138 0 3	9	1.750	1.82	-0.239	0.243	6.2	-1.0	0.897	0.966	9.19e-26	2.7	0.185	0.817	2.7	0.0	0.961	0.947	2.27e-22
HCC70	QL-XII-108	1	sigmoid	sigmoid	HCC70 QL-XII-108 0 1	9	1.598	1.64	0.0903	0.226	2.06	-0.115	0.914	0.963	5.57e-25	3.65	0.379	0.836	1.5	0.287	0.962	0.954	1.98e-23
HCC70	QL-XII-108	2	sigmoid	sigmoid	HCC70 QL-XII-108 0 2	9	1.573	1.64	0.0651	0.189	1.78	-0.0491	1.11	0.948	1.42e-22	3.36	0.371	0.867	1.34	0.336	1.2	0.936	4.76e-21
HCC70	QL-XII-108	3	sigmoid	sigmoid	HCC70 QL-XII-108 0 3	9	1.750	1.72	0.15	0.238	2.29	-0.122	0.763	0.951	5.13e-23	3.53	0.38	0.813	1.52	0.245	0.796	0.937	3.73e-21
HCC70	QL-XII-47	1	sigmoid	sigmoid	HCC70 QL-XII-47 0 1	9	1.598	0.767	-0.806	0.406	1.22	-0.822	2.11	0.994	3.85e-38	0.971	0.0243	0.758	0.954	0.0199	2.33	0.989	7.52e-34

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HMS LINCS Project

Evaluation of the sensitivity of two triple-negative breast cancer cell lines (HCC1806, HCC70) to a collection of dual mTOR and PI3K-like kinase (PIKK) inhibitors. Dataset 2 of 2: GR metrics. - Dataset (ID:20367)