Evaluation of the sensitivity of two triple-negative breast cancer cell lines (HCC1806, HCC70) to a collection of dual mTOR and PI3K-like kinase (PIKK) inhibitors. Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivity of two triple-negative breast cancer cell lines (HCC1806, HCC70) to a collection of dual mTOR and PI3K-like kinase (PIKK) inhibitors. Dataset 2 of 2: GR metrics. - Dataset (ID:20367)

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Cell line	Drug name	Experimental replicate	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared curve fit (GR values)	P-value curve fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared curve fit (relative cell counts)	P-value curve fit (relative cell counts)
HCC70	QL-XII-61	2	sigmoid	sigmoid	HCC70 QL-XII-61 0 2	9	1.573	4.5	0.179	0.0498	4.14	0.169	5.0	0.928	3.35e-20	5.98	0.436	0.967	4.03	0.43	5.0	0.913	1.01e-18
HCC70	QL-IV-100	2	sigmoid	sigmoid	HCC70 QL-IV-100 0 2	9	1.573	0.0891	-0.75	0.716	0.451	-1.0	0.678	0.986	2.16e-32	0.18	0.0381	0.549	0.18	0.0	0.729	0.977	1.02e-28
HCC70	QL-V-107	2	sigmoid	sigmoid	HCC70 QL-V-107 0 2	9	1.573	0.0752	-0.655	0.721	0.361	-0.895	0.653	0.99	7.55e-35	0.163	0.0632	0.541	0.163	0.0	0.682	0.987	1.08e-32
HCC1806	QL-XII-108	3	sigmoid	sigmoid	HCC1806 QL-XII-108 0 3	9	2.697	4.76	0.208	0.11	5.85	-0.166	1.39	0.964	2.49e-25	4.23	0.262	0.882	3.69	0.0906	1.46	0.97	1.09e-26
HCC1806	QL-XII-61	3	sigmoid	sigmoid	HCC1806 QL-XII-61 0 3	9	2.697	5.77	0.315	0.0462	4.81	0.298	5.0	0.976	3.4e-28	5.48	0.324	0.954	4.51	0.311	5.0	0.961	1.27e-24
HCC1806	QL-X-138	1	sigmoid	sigmoid	HCC1806 QL-X-138 0 1	9	2.619	6.42	0.243	0.0784	13.0	-0.855	1.41	0.992	2.35e-36	5.79	0.288	0.918	5.79	0.0	1.63	0.987	1.31e-32
HCC70	QL-IV-100	3	sigmoid	sigmoid	HCC70 QL-IV-100 0 3	9	1.750	0.129	-0.657	0.638	0.443	-0.822	0.786	0.989	2.41e-34	0.208	0.0458	0.575	0.208	0.0	0.819	0.985	1.33e-31
HCC70	QL-V-107	3	sigmoid	sigmoid	HCC70 QL-V-107 0 3	9	1.750	0.14	-0.593	0.616	0.414	-0.728	0.829	0.994	4.36e-39	0.227	0.0616	0.585	0.222	0.0103	0.847	0.991	1.33e-35
HCC70	QL-XII-61	1	sigmoid	sigmoid	HCC70 QL-XII-61 0 1	9	1.598	6.18	0.125	0.0875	11.5	-1.0	1.76	0.946	2.8e-22	8.07	0.399	0.937	8.07	0.0	1.9	0.932	1.35e-20
HCC1806	QL-XII-108	2	sigmoid	sigmoid	HCC1806 QL-XII-108 0 2	9	2.714	6.59	0.385	0.105	5.93	0.0605	1.22	0.87	9.22e-16	5.58	0.369	0.88	4.06	0.163	1.24	0.847	1.36e-14
HCC1806	QL-V-107	3	sigmoid	sigmoid	HCC1806 QL-V-107 0 3	9	2.697	0.519	-0.346	0.402	1.01	-0.489	1.03	0.965	1.52e-25	0.443	0.0491	0.645	0.435	0.00946	1.1	0.932	1.36e-20
HCC70	AZD8055	1	sigmoid	sigmoid	HCC70 AZD8055 0 1	9	1.598	0.0382	0.0624	0.564	0.0292	0.0882	0.722	0.969	1.75e-26	0.158	0.364	0.601	0.0229	0.379	0.734	0.965	1.44e-25
HCC70	QL-XII-47	2	sigmoid	sigmoid	HCC70 QL-XII-47 0 2	9	1.573	0.728	-0.818	0.401	1.07	-0.805	2.49	0.991	6.84e-36	0.901	0.0231	0.771	0.883	0.029	2.89	0.985	1.44e-31
HCC70	AZD8055	3	sigmoid	sigmoid	HCC70 AZD8055 0 3	9	1.750	0.0456	0.0533	0.54	0.0343	0.105	0.837	0.979	2.64e-29	0.109	0.326	0.593	0.026	0.359	0.885	0.98	1.62e-29
HCC70	QL-XII-47	3	sigmoid	sigmoid	HCC70 QL-XII-47 0 3	9	1.750	0.67	-0.681	0.457	0.98	-0.726	2.37	0.993	4e-37	0.776	0.0408	0.712	0.76	0.022	2.23	0.988	1.63e-33
HCC70	Torin2	1	sigmoid	sigmoid	HCC70 Torin2 0 1	9	1.598	0.014	-0.946	1.07	0.0747	-1.0	0.657	0.991	3.28e-35	0.0269	0.00323	0.362	0.0269	0.0	0.682	0.988	1.64e-33
HCC1806	QL-VI-86	1	sigmoid	sigmoid	HCC1806 QL-VI-86 0 1	9	2.619	1.41	-0.214	0.244	2.16	-0.376	1.31	0.997	1.33e-44	1.28	0.0866	0.776	1.21	0.0401	1.42	0.995	1.89e-39
HCC70	QL-XII-108	1	sigmoid	sigmoid	HCC70 QL-XII-108 0 1	9	1.598	1.64	0.0903	0.226	2.06	-0.115	0.914	0.963	5.57e-25	3.65	0.379	0.836	1.5	0.287	0.962	0.954	1.98e-23
HCC70	QL-V-73	1	sigmoid	sigmoid	HCC70 QL-V-73 0 1	9	1.598	0.538	-0.558	0.42	2.22	-1.0	0.774	0.987	5.03e-33	0.973	0.0898	0.716	0.973	0.0	0.812	0.98	1.98e-29
HCC1806	QL-IV-100	3	sigmoid	sigmoid	HCC1806 QL-IV-100 0 3	9	2.697	0.287	-0.301	0.472	0.412	-0.344	1.45	0.995	2.12e-39	0.252	0.0588	0.608	0.24	0.0305	1.31	0.992	2.13e-36
HCC70	QL-X-138	3	sigmoid	sigmoid	HCC70 QL-X-138 0 3	9	1.750	1.82	-0.239	0.243	6.2	-1.0	0.897	0.966	9.19e-26	2.7	0.185	0.817	2.7	0.0	0.961	0.947	2.27e-22
HCC1806	QL-X-138	3	sigmoid	sigmoid	HCC1806 QL-X-138 0 3	9	2.697	6.59	0.283	0.0757	10.6	-0.493	1.46	0.982	2.01e-30	5.91	0.302	0.919	5.91	0.0	1.58	0.969	2.38e-26
HCC1806	QL-VIII-58	2	sigmoid	sigmoid	HCC1806 QL-VIII-58 0 2	9	2.714	0.377	-0.671	0.481	1.56	-1.0	0.773	0.938	2.91e-21	0.267	0.00748	0.596	0.267	0.0	0.778	0.895	2.46e-17
HCC1806	QL-XII-108	1	sigmoid	sigmoid	HCC1806 QL-XII-108 0 1	9	2.619	7.21	0.374	0.081	12.1	-0.403	1.15	0.986	2.16e-32	6.53	0.374	0.911	6.53	0.0	1.2	0.979	2.47e-29
HCC1806	AZD8055	3	sigmoid	sigmoid	HCC1806 AZD8055 0 3	9	2.697	0.249	0.382	0.325	0.0778	0.383	1.25	0.992	1.75e-36	0.177	0.369	0.652	0.061	0.37	1.26	0.992	2.49e-36

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HMS LINCS Project

Evaluation of the sensitivity of two triple-negative breast cancer cell lines (HCC1806, HCC70) to a collection of dual mTOR and PI3K-like kinase (PIKK) inhibitors. Dataset 2 of 2: GR metrics. - Dataset (ID:20367)