Evaluation of the sensitivity of two triple-negative breast cancer cell lines (HCC1806, HCC70) to a collection of dual mTOR and PI3K-like kinase (PIKK) inhibitors. Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivity of two triple-negative breast cancer cell lines (HCC1806, HCC70) to a collection of dual mTOR and PI3K-like kinase (PIKK) inhibitors. Dataset 2 of 2: GR metrics. - Dataset (ID:20367)

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Cell line	Drug name	Experimental replicate	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared curve fit (GR values)	P-value curve fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared curve fit (relative cell counts)	P-value curve fit (relative cell counts)
HCC70	QL-VI-86	2	sigmoid	sigmoid	HCC70 QL-VI-86 0 2	9	1.573	0.266	-0.695	0.519	0.899	-0.926	0.861	0.989	1.06e-33	0.467	0.052	0.672	0.467	0.0	0.934	0.983	9.31e-31
HCC70	QL-VIII-58	3	sigmoid	sigmoid	HCC70 QL-VIII-58 0 3	9	1.750	0.0774	-0.942	0.769	0.364	-1.0	0.709	0.974	1.07e-27	0.115	0.00207	0.506	0.115	0.0	0.688	0.979	3.76e-29
HCC70	QL-X-138	2	sigmoid	sigmoid	HCC70 QL-X-138 0 2	9	1.573	1.62	-0.286	0.211	3.74	-0.725	1.07	0.966	1.18e-25	2.65	0.198	0.859	2.44	0.045	1.14	0.953	3.05e-23
HCC1806	QL-VI-86	1	sigmoid	sigmoid	HCC1806 QL-VI-86 0 1	9	2.619	1.41	-0.214	0.244	2.16	-0.376	1.31	0.997	1.33e-44	1.28	0.0866	0.776	1.21	0.0401	1.42	0.995	1.89e-39
HCC70	QL-XII-108	2	sigmoid	sigmoid	HCC70 QL-XII-108 0 2	9	1.573	1.64	0.0651	0.189	1.78	-0.0491	1.11	0.948	1.42e-22	3.36	0.371	0.867	1.34	0.336	1.2	0.936	4.76e-21
HCC1806	QL-XII-61	2	sigmoid	sigmoid	HCC1806 QL-XII-61 0 2	9	2.714	5.89	0.373	0.0452	4.56	0.36	5.0	0.979	1.48e-27	5.48	0.361	0.953	4.3	0.352	5.0	0.971	2.71e-25
HCC1806	QL-V-107	3	sigmoid	sigmoid	HCC1806 QL-V-107 0 3	9	2.697	0.519	-0.346	0.402	1.01	-0.489	1.03	0.965	1.52e-25	0.443	0.0491	0.645	0.435	0.00946	1.1	0.932	1.36e-20
HCC70	Torin1	1	sigmoid	sigmoid	HCC70 Torin1 0 1	9	1.598	0.061	-0.147	0.573	0.0884	-0.134	0.64	0.954	1.68e-23	0.182	0.256	0.601	0.057	0.275	0.684	0.957	6.27e-24
HCC70	AZD8055	1	sigmoid	sigmoid	HCC70 AZD8055 0 1	9	1.598	0.0382	0.0624	0.564	0.0292	0.0882	0.722	0.969	1.75e-26	0.158	0.364	0.601	0.0229	0.379	0.734	0.965	1.44e-25
HCC1806	AZD8055	3	sigmoid	sigmoid	HCC1806 AZD8055 0 3	9	2.697	0.249	0.382	0.325	0.0778	0.383	1.25	0.992	1.75e-36	0.177	0.369	0.652	0.061	0.37	1.26	0.992	2.49e-36
HCC70	Torin2	2	sigmoid	sigmoid	HCC70 Torin2 0 2	9	1.573	0.0124	-0.955	1.11	0.0639	-1.0	0.669	0.99	1.92e-34	0.0242	0.00262	0.351	0.0242	0.0	0.695	0.987	7.52e-33
HCC1806	QL-VIII-58	3	sigmoid	sigmoid	HCC1806 QL-VIII-58 0 3	9	2.697	0.386	-0.758	0.491	1.25	-1.0	0.936	0.991	1.99e-35	0.289	0.00336	0.612	0.289	0.0	1.04	0.987	8.61e-33
HCC1806	QL-X-138	3	sigmoid	sigmoid	HCC1806 QL-X-138 0 3	9	2.697	6.59	0.283	0.0757	10.6	-0.493	1.46	0.982	2.01e-30	5.91	0.302	0.919	5.91	0.0	1.58	0.969	2.38e-26
HCC70	QL-V-73	3	sigmoid	sigmoid	HCC70 QL-V-73 0 3	9	1.750	0.729	-0.527	0.364	2.62	-1.0	0.859	0.991	2.06e-35	1.08	0.0803	0.743	1.08	0.0	0.961	0.983	6.66e-31
HCC1806	QL-IV-100	3	sigmoid	sigmoid	HCC1806 QL-IV-100 0 3	9	2.697	0.287	-0.301	0.472	0.412	-0.344	1.45	0.995	2.12e-39	0.252	0.0588	0.608	0.24	0.0305	1.31	0.992	2.13e-36
HCC70	QL-IV-100	2	sigmoid	sigmoid	HCC70 QL-IV-100 0 2	9	1.573	0.0891	-0.75	0.716	0.451	-1.0	0.678	0.986	2.16e-32	0.18	0.0381	0.549	0.18	0.0	0.729	0.977	1.02e-28
HCC1806	QL-XII-108	1	sigmoid	sigmoid	HCC1806 QL-XII-108 0 1	9	2.619	7.21	0.374	0.081	12.1	-0.403	1.15	0.986	2.16e-32	6.53	0.374	0.911	6.53	0.0	1.2	0.979	2.47e-29
HCC1806	AZD8055	2	sigmoid	sigmoid	HCC1806 AZD8055 0 2	9	2.714	0.738	0.43	0.289	0.094	0.437	1.01	0.947	2.1e-22	0.387	0.402	0.678	0.0732	0.405	0.999	0.935	6.08e-21
HCC70	QL-XII-61	3	sigmoid	sigmoid	HCC70 QL-XII-61 0 3	9	1.750	6.08	0.145	0.111	12.1	-1.0	1.6	0.908	2.21e-18	7.62	0.377	0.913	7.62	0.0	1.76	0.879	2.58e-16
HCC1806	Torin2	2	sigmoid	sigmoid	HCC1806 Torin2 0 2	9	2.714	0.0767	-0.467	0.658	0.13	-0.401	1.12	0.99	2.21e-34	0.0654	0.0278	0.465	0.062	0.0296	1.13	0.994	4.16e-38
HCC1806	QL-X-138	2	sigmoid	sigmoid	HCC1806 QL-X-138 0 2	9	2.714	6.65	0.278	0.084	15.6	-1.0	1.29	0.989	2.34e-34	5.77	0.297	0.907	5.77	0.0	1.52	0.982	3.19e-30
HCC70	Torin2	3	sigmoid	sigmoid	HCC70 Torin2 0 3	9	1.750	0.018	-0.94	1.03	0.0947	-1.0	0.661	0.992	2.34e-36	0.0285	0.00226	0.367	0.0285	0.0	0.704	0.99	4.9e-35
HCC1806	QL-X-138	1	sigmoid	sigmoid	HCC1806 QL-X-138 0 1	9	2.619	6.42	0.243	0.0784	13.0	-0.855	1.41	0.992	2.35e-36	5.79	0.288	0.918	5.79	0.0	1.63	0.987	1.31e-32
HCC70	QL-IV-100	3	sigmoid	sigmoid	HCC70 QL-IV-100 0 3	9	1.750	0.129	-0.657	0.638	0.443	-0.822	0.786	0.989	2.41e-34	0.208	0.0458	0.575	0.208	0.0	0.819	0.985	1.33e-31
HCC1806	QL-XII-108	3	sigmoid	sigmoid	HCC1806 QL-XII-108 0 3	9	2.697	4.76	0.208	0.11	5.85	-0.166	1.39	0.964	2.49e-25	4.23	0.262	0.882	3.69	0.0906	1.46	0.97	1.09e-26

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HMS LINCS Project

Evaluation of the sensitivity of two triple-negative breast cancer cell lines (HCC1806, HCC70) to a collection of dual mTOR and PI3K-like kinase (PIKK) inhibitors. Dataset 2 of 2: GR metrics. - Dataset (ID:20367)