Evaluation of the sensitivity of two triple-negative breast cancer cell lines (HCC1806, HCC70) to a collection of dual mTOR and PI3K-like kinase (PIKK) inhibitors. Dataset 2 of 2: GR metrics. - Dataset (ID:20367)

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Cell line Drug name Experimental replicate Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared curve fit (GR values) P-value curve fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared curve fit (relative cell counts) P-value curve fit (relative cell counts)
HCC1806 QL-V-107 2
sigmoid
sigmoid
HCC1806 QL-V-107 0 2
 9 2.714
0.604
-0.279
0.364
1.09
-0.428
1.05
0.995
5.69e-40
0.517
0.0629
0.672
0.517
0.0
1.02
0.994
2.98e-38
HCC70 QL-IV-100 3
sigmoid
sigmoid
HCC70 QL-IV-100 0 3
 9 1.750
0.129
-0.657
0.638
0.443
-0.822
0.786
0.989
2.41e-34
0.208
0.0458
0.575
0.208
0.0
0.819
0.985
1.33e-31
HCC70 Torin2 1
sigmoid
sigmoid
HCC70 Torin2 0 1
 9 1.598
0.014
-0.946
1.07
0.0747
-1.0
0.657
0.991
3.28e-35
0.0269
0.00323
0.362
0.0269
0.0
0.682
0.988
1.64e-33
HCC70 QL-XII-61 3
sigmoid
sigmoid
HCC70 QL-XII-61 0 3
 9 1.750
6.08
0.145
0.111
12.1
-1.0
1.6
0.908
2.21e-18
7.62
0.377
0.913
7.62
0.0
1.76
0.879
2.58e-16
HCC1806 QL-VIII-58 1
sigmoid
sigmoid
HCC1806 QL-VIII-58 0 1
 9 2.619
0.471
-0.657
0.441
1.51
-0.961
0.923
0.997
8.08e-44
0.388
0.00996
0.645
0.388
0.0
1.08
0.993
3.33e-37
HCC70 QL-V-107 1
sigmoid
sigmoid
HCC70 QL-V-107 0 1
 9 1.598
0.0994
-0.612
0.672
0.409
-0.834
0.694
0.988
3.47e-33
0.206
0.0727
0.566
0.206
0.0
0.712
0.984
4.79e-31
HCC70 QL-V-107 2
sigmoid
sigmoid
HCC70 QL-V-107 0 2
 9 1.573
0.0752
-0.655
0.721
0.361
-0.895
0.653
0.99
7.55e-35
0.163
0.0632
0.541
0.163
0.0
0.682
0.987
1.08e-32
HCC70 Torin2 2
sigmoid
sigmoid
HCC70 Torin2 0 2
 9 1.573
0.0124
-0.955
1.11
0.0639
-1.0
0.669
0.99
1.92e-34
0.0242
0.00262
0.351
0.0242
0.0
0.695
0.987
7.52e-33
HCC70 QL-IV-100 2
sigmoid
sigmoid
HCC70 QL-IV-100 0 2
 9 1.573
0.0891
-0.75
0.716
0.451
-1.0
0.678
0.986
2.16e-32
0.18
0.0381
0.549
0.18
0.0
0.729
0.977
1.02e-28
HCC70 QL-XII-61 1
sigmoid
sigmoid
HCC70 QL-XII-61 0 1
 9 1.598
6.18
0.125
0.0875
11.5
-1.0
1.76
0.946
2.8e-22
8.07
0.399
0.937
8.07
0.0
1.9
0.932
1.35e-20
HCC70 Torin2 3
sigmoid
sigmoid
HCC70 Torin2 0 3
 9 1.750
0.018
-0.94
1.03
0.0947
-1.0
0.661
0.992
2.34e-36
0.0285
0.00226
0.367
0.0285
0.0
0.704
0.99
4.9e-35
HCC1806 QL-V-107 1
sigmoid
sigmoid
HCC1806 QL-V-107 0 1
 9 2.619
0.586
-0.315
0.383
1.03
-0.442
1.12
0.993
7.41e-38
0.53
0.0606
0.662
0.53
0.0
1.07
0.989
6.64e-34
HCC70 QL-VI-86 2
sigmoid
sigmoid
HCC70 QL-VI-86 0 2
 9 1.573
0.266
-0.695
0.519
0.899
-0.926
0.861
0.989
1.06e-33
0.467
0.052
0.672
0.467
0.0
0.934
0.983
9.31e-31
HCC70 QL-VI-86 3
sigmoid
sigmoid
HCC70 QL-VI-86 0 3
 9 1.750
0.305
-0.639
0.508
1.34
-1.0
0.742
0.989
4.41e-34
0.478
0.0501
0.649
0.478
0.0
0.81
0.981
5.26e-30
HCC70 QL-VIII-58 1
sigmoid
sigmoid
HCC70 QL-VIII-58 0 1
 9 1.598
0.0739
-0.976
0.791
0.319
-1.0
0.752
0.972
4.08e-27
0.127
0.000989
0.519
0.127
0.0
0.723
0.981
6.68e-30
HCC70 QL-VIII-58 2
sigmoid
sigmoid
HCC70 QL-VIII-58 0 2
 9 1.573
0.0674
-0.973
0.806
0.287
-1.0
0.759
0.972
3.07e-27
0.12
0.00122
0.517
0.12
0.0
0.752
0.975
6.9e-28
HCC70 QL-VIII-58 3
sigmoid
sigmoid
HCC70 QL-VIII-58 0 3
 9 1.750
0.0774
-0.942
0.769
0.364
-1.0
0.709
0.974
1.07e-27
0.115
0.00207
0.506
0.115
0.0
0.688
0.979
3.76e-29
HCC70 QL-IV-100 1
sigmoid
sigmoid
HCC70 QL-IV-100 0 1
 9 1.598
0.115
-0.713
0.67
0.502
-0.951
0.723
0.992
2.58e-36
0.219
0.045
0.574
0.219
0.0
0.776
0.989
2.4e-34
HCC70 QL-V-73 1
sigmoid
sigmoid
HCC70 QL-V-73 0 1
 9 1.598
0.538
-0.558
0.42
2.22
-1.0
0.774
0.987
5.03e-33
0.973
0.0898
0.716
0.973
0.0
0.812
0.98
1.98e-29
HCC70 QL-X-138 3
sigmoid
sigmoid
HCC70 QL-X-138 0 3
 9 1.750
1.82
-0.239
0.243
6.2
-1.0
0.897
0.966
9.19e-26
2.7
0.185
0.817
2.7
0.0
0.961
0.947
2.27e-22
HCC70 QL-V-73 2
sigmoid
sigmoid
HCC70 QL-V-73 0 2
 9 1.573
0.397
-0.619
0.474
1.71
-1.0
0.751
0.983
7.11e-31
0.749
0.0739
0.686
0.749
0.0
0.776
0.972
4.32e-27
HCC70 QL-VI-86 1
sigmoid
sigmoid
HCC70 QL-VI-86 0 1
 9 1.598
0.299
-0.674
0.511
1.21
-1.0
0.786
0.987
7.69e-33
0.529
0.0552
0.668
0.529
0.0
0.854
0.981
5.86e-30
HCC70 QL-V-73 3
sigmoid
sigmoid
HCC70 QL-V-73 0 3
 9 1.750
0.729
-0.527
0.364
2.62
-1.0
0.859
0.991
2.06e-35
1.08
0.0803
0.743
1.08
0.0
0.961
0.983
6.66e-31
HCC1806 QL-VIII-58 3
sigmoid
sigmoid
HCC1806 QL-VIII-58 0 3
 9 2.697
0.386
-0.758
0.491
1.25
-1.0
0.936
0.991
1.99e-35
0.289
0.00336
0.612
0.289
0.0
1.04
0.987
8.61e-33
HCC1806 QL-VIII-58 2
sigmoid
sigmoid
HCC1806 QL-VIII-58 0 2
 9 2.714
0.377
-0.671
0.481
1.56
-1.0
0.773
0.938
2.91e-21
0.267
0.00748
0.596
0.267
0.0
0.778
0.895
2.46e-17
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