Evaluation of the sensitivity of two triple-negative breast cancer cell lines (HCC1806, HCC70) to a collection of dual mTOR and PI3K-like kinase (PIKK) inhibitors. Dataset 2 of 2: GR metrics. - Dataset (ID:20367)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell line | Drug name | Experimental replicate | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared curve fit (GR values) | P-value curve fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared curve fit (relative cell counts) | P-value curve fit (relative cell counts) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | QL-XII-108 | 2 | sigmoid | sigmoid | HCC1806 QL-XII-108 0 2 | 9 | 2.714 | 6.59 | 0.385 | 0.105 | 5.93 | 0.0605 | 1.22 | 0.87 | 9.22e-16 | 5.58 | 0.369 | 0.88 | 4.06 | 0.163 | 1.24 | 0.847 | 1.36e-14 |
| HCC70 | QL-XII-61 | 3 | sigmoid | sigmoid | HCC70 QL-XII-61 0 3 | 9 | 1.750 | 6.08 | 0.145 | 0.111 | 12.1 | -1.0 | 1.6 | 0.908 | 2.21e-18 | 7.62 | 0.377 | 0.913 | 7.62 | 0.0 | 1.76 | 0.879 | 2.58e-16 |
| HCC70 | QL-XII-61 | 2 | sigmoid | sigmoid | HCC70 QL-XII-61 0 2 | 9 | 1.573 | 4.5 | 0.179 | 0.0498 | 4.14 | 0.169 | 5.0 | 0.928 | 3.35e-20 | 5.98 | 0.436 | 0.967 | 4.03 | 0.43 | 5.0 | 0.913 | 1.01e-18 |
| HCC1806 | QL-VIII-58 | 2 | sigmoid | sigmoid | HCC1806 QL-VIII-58 0 2 | 9 | 2.714 | 0.377 | -0.671 | 0.481 | 1.56 | -1.0 | 0.773 | 0.938 | 2.91e-21 | 0.267 | 0.00748 | 0.596 | 0.267 | 0.0 | 0.778 | 0.895 | 2.46e-17 |
| HCC70 | QL-XII-61 | 1 | sigmoid | sigmoid | HCC70 QL-XII-61 0 1 | 9 | 1.598 | 6.18 | 0.125 | 0.0875 | 11.5 | -1.0 | 1.76 | 0.946 | 2.8e-22 | 8.07 | 0.399 | 0.937 | 8.07 | 0.0 | 1.9 | 0.932 | 1.35e-20 |
| HCC1806 | AZD8055 | 2 | sigmoid | sigmoid | HCC1806 AZD8055 0 2 | 9 | 2.714 | 0.738 | 0.43 | 0.289 | 0.094 | 0.437 | 1.01 | 0.947 | 2.1e-22 | 0.387 | 0.402 | 0.678 | 0.0732 | 0.405 | 0.999 | 0.935 | 6.08e-21 |
| HCC70 | QL-XII-108 | 2 | sigmoid | sigmoid | HCC70 QL-XII-108 0 2 | 9 | 1.573 | 1.64 | 0.0651 | 0.189 | 1.78 | -0.0491 | 1.11 | 0.948 | 1.42e-22 | 3.36 | 0.371 | 0.867 | 1.34 | 0.336 | 1.2 | 0.936 | 4.76e-21 |
| HCC70 | QL-XII-108 | 3 | sigmoid | sigmoid | HCC70 QL-XII-108 0 3 | 9 | 1.750 | 1.72 | 0.15 | 0.238 | 2.29 | -0.122 | 0.763 | 0.951 | 5.13e-23 | 3.53 | 0.38 | 0.813 | 1.52 | 0.245 | 0.796 | 0.937 | 3.73e-21 |
| HCC70 | Torin1 | 1 | sigmoid | sigmoid | HCC70 Torin1 0 1 | 9 | 1.598 | 0.061 | -0.147 | 0.573 | 0.0884 | -0.134 | 0.64 | 0.954 | 1.68e-23 | 0.182 | 0.256 | 0.601 | 0.057 | 0.275 | 0.684 | 0.957 | 6.27e-24 |
| HCC70 | Torin1 | 2 | sigmoid | sigmoid | HCC70 Torin1 0 2 | 9 | 1.573 | 0.0399 | -0.322 | 0.653 | 0.107 | -0.343 | 0.53 | 0.962 | 7.04e-25 | 0.123 | 0.183 | 0.557 | 0.0522 | 0.201 | 0.6 | 0.964 | 3.46e-25 |
| HCC1806 | QL-XII-61 | 1 | sigmoid | sigmoid | HCC1806 QL-XII-61 0 1 | 9 | 2.619 | 6.9 | 0.407 | 0.0291 | 5.14 | 0.386 | 5.0 | 0.962 | 5.78e-25 | 6.52 | 0.4 | 0.974 | 4.87 | 0.384 | 5.0 | 0.956 | 8.68e-24 |
| HCC70 | QL-XII-108 | 1 | sigmoid | sigmoid | HCC70 QL-XII-108 0 1 | 9 | 1.598 | 1.64 | 0.0903 | 0.226 | 2.06 | -0.115 | 0.914 | 0.963 | 5.57e-25 | 3.65 | 0.379 | 0.836 | 1.5 | 0.287 | 0.962 | 0.954 | 1.98e-23 |
| HCC1806 | QL-XII-108 | 3 | sigmoid | sigmoid | HCC1806 QL-XII-108 0 3 | 9 | 2.697 | 4.76 | 0.208 | 0.11 | 5.85 | -0.166 | 1.39 | 0.964 | 2.49e-25 | 4.23 | 0.262 | 0.882 | 3.69 | 0.0906 | 1.46 | 0.97 | 1.09e-26 |
| HCC1806 | QL-V-107 | 3 | sigmoid | sigmoid | HCC1806 QL-V-107 0 3 | 9 | 2.697 | 0.519 | -0.346 | 0.402 | 1.01 | -0.489 | 1.03 | 0.965 | 1.52e-25 | 0.443 | 0.0491 | 0.645 | 0.435 | 0.00946 | 1.1 | 0.932 | 1.36e-20 |
| HCC70 | QL-X-138 | 3 | sigmoid | sigmoid | HCC70 QL-X-138 0 3 | 9 | 1.750 | 1.82 | -0.239 | 0.243 | 6.2 | -1.0 | 0.897 | 0.966 | 9.19e-26 | 2.7 | 0.185 | 0.817 | 2.7 | 0.0 | 0.961 | 0.947 | 2.27e-22 |
| HCC70 | QL-X-138 | 2 | sigmoid | sigmoid | HCC70 QL-X-138 0 2 | 9 | 1.573 | 1.62 | -0.286 | 0.211 | 3.74 | -0.725 | 1.07 | 0.966 | 1.18e-25 | 2.65 | 0.198 | 0.859 | 2.44 | 0.045 | 1.14 | 0.953 | 3.05e-23 |
| HCC70 | Torin1 | 3 | sigmoid | sigmoid | HCC70 Torin1 0 3 | 9 | 1.750 | 0.0678 | -0.133 | 0.547 | 0.0833 | -0.0781 | 0.706 | 0.967 | 3.43e-25 | 0.133 | 0.232 | 0.596 | 0.0487 | 0.284 | 0.833 | 0.971 | 4.17e-26 |
| HCC70 | AZD8055 | 1 | sigmoid | sigmoid | HCC70 AZD8055 0 1 | 9 | 1.598 | 0.0382 | 0.0624 | 0.564 | 0.0292 | 0.0882 | 0.722 | 0.969 | 1.75e-26 | 0.158 | 0.364 | 0.601 | 0.0229 | 0.379 | 0.734 | 0.965 | 1.44e-25 |
| HCC1806 | Torin1 | 1 | sigmoid | sigmoid | HCC1806 Torin1 0 1 | 9 | 2.619 | 0.515 | 0.179 | 0.326 | 0.302 | 0.148 | 0.662 | 0.971 | 9.22e-27 | 0.347 | 0.251 | 0.66 | 0.129 | 0.272 | 0.796 | 0.975 | 8.08e-28 |
| HCC1806 | Torin1 | 3 | sigmoid | sigmoid | HCC1806 Torin1 0 3 | 9 | 2.697 | 0.393 | 0.144 | 0.339 | 0.25 | 0.145 | 0.753 | 0.972 | 4.9e-27 | 0.243 | 0.222 | 0.648 | 0.112 | 0.264 | 0.964 | 0.972 | 5.22e-27 |
| HCC70 | AZD8055 | 2 | sigmoid | sigmoid | HCC70 AZD8055 0 2 | 9 | 1.573 | 0.029 | -0.0375 | 0.612 | 0.0272 | 0.0241 | 0.792 | 0.972 | 3.37e-27 | 0.0959 | 0.317 | 0.576 | 0.0216 | 0.35 | 0.808 | 0.974 | 9.92e-28 |
| HCC70 | QL-VIII-58 | 2 | sigmoid | sigmoid | HCC70 QL-VIII-58 0 2 | 9 | 1.573 | 0.0674 | -0.973 | 0.806 | 0.287 | -1.0 | 0.759 | 0.972 | 3.07e-27 | 0.12 | 0.00122 | 0.517 | 0.12 | 0.0 | 0.752 | 0.975 | 6.9e-28 |
| HCC70 | QL-VIII-58 | 1 | sigmoid | sigmoid | HCC70 QL-VIII-58 0 1 | 9 | 1.598 | 0.0739 | -0.976 | 0.791 | 0.319 | -1.0 | 0.752 | 0.972 | 4.08e-27 | 0.127 | 0.000989 | 0.519 | 0.127 | 0.0 | 0.723 | 0.981 | 6.68e-30 |
| HCC70 | QL-VIII-58 | 3 | sigmoid | sigmoid | HCC70 QL-VIII-58 0 3 | 9 | 1.750 | 0.0774 | -0.942 | 0.769 | 0.364 | -1.0 | 0.709 | 0.974 | 1.07e-27 | 0.115 | 0.00207 | 0.506 | 0.115 | 0.0 | 0.688 | 0.979 | 3.76e-29 |
| HCC1806 | QL-XII-61 | 3 | sigmoid | sigmoid | HCC1806 QL-XII-61 0 3 | 9 | 2.697 | 5.77 | 0.315 | 0.0462 | 4.81 | 0.298 | 5.0 | 0.976 | 3.4e-28 | 5.48 | 0.324 | 0.954 | 4.51 | 0.311 | 5.0 | 0.961 | 1.27e-24 |