Evaluation of the sensitivity of two triple-negative breast cancer cell lines (HCC1806, HCC70) to a collection of dual mTOR and PI3K-like kinase (PIKK) inhibitors. Dataset 2 of 2: GR metrics. - Dataset (ID:20367)

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Cell line Drug name Experimental replicate Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared curve fit (GR values) P-value curve fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared curve fit (relative cell counts) P-value curve fit (relative cell counts)
HCC70 Torin2 2
sigmoid
sigmoid
HCC70 Torin2 0 2
 9 1.573
0.0124
-0.955
1.11
0.0639
-1.0
0.669
0.99
1.92e-34
0.0242
0.00262
0.351
0.0242
0.0
0.695
0.987
7.52e-33
HCC70 Torin2 1
sigmoid
sigmoid
HCC70 Torin2 0 1
 9 1.598
0.014
-0.946
1.07
0.0747
-1.0
0.657
0.991
3.28e-35
0.0269
0.00323
0.362
0.0269
0.0
0.682
0.988
1.64e-33
HCC70 Torin2 3
sigmoid
sigmoid
HCC70 Torin2 0 3
 9 1.750
0.018
-0.94
1.03
0.0947
-1.0
0.661
0.992
2.34e-36
0.0285
0.00226
0.367
0.0285
0.0
0.704
0.99
4.9e-35
HCC1806 Torin2 3
sigmoid
sigmoid
HCC1806 Torin2 0 3
 9 2.697
0.06
-0.564
0.7
0.119
-0.475
0.977
0.987
4.74e-33
0.0508
0.0164
0.441
0.0481
0.0316
1.17
0.993
3.18e-37
HCC1806 Torin2 1
sigmoid
sigmoid
HCC1806 Torin2 0 1
 9 2.619
0.0655
-0.43
0.683
0.107
-0.389
1.17
0.994
7.49e-39
0.0584
0.0375
0.456
0.0546
0.0391
1.2
0.997
3.89e-44
HCC1806 Torin2 2
sigmoid
sigmoid
HCC1806 Torin2 0 2
 9 2.714
0.0767
-0.467
0.658
0.13
-0.401
1.12
0.99
2.21e-34
0.0654
0.0278
0.465
0.062
0.0296
1.13
0.994
4.16e-38
HCC70 AZD8055 2
sigmoid
sigmoid
HCC70 AZD8055 0 2
 9 1.573
0.029
-0.0375
0.612
0.0272
0.0241
0.792
0.972
3.37e-27
0.0959
0.317
0.576
0.0216
0.35
0.808
0.974
9.92e-28
HCC70 AZD8055 3
sigmoid
sigmoid
HCC70 AZD8055 0 3
 9 1.750
0.0456
0.0533
0.54
0.0343
0.105
0.837
0.979
2.64e-29
0.109
0.326
0.593
0.026
0.359
0.885
0.98
1.62e-29
HCC70 QL-VIII-58 3
sigmoid
sigmoid
HCC70 QL-VIII-58 0 3
 9 1.750
0.0774
-0.942
0.769
0.364
-1.0
0.709
0.974
1.07e-27
0.115
0.00207
0.506
0.115
0.0
0.688
0.979
3.76e-29
HCC70 QL-VIII-58 2
sigmoid
sigmoid
HCC70 QL-VIII-58 0 2
 9 1.573
0.0674
-0.973
0.806
0.287
-1.0
0.759
0.972
3.07e-27
0.12
0.00122
0.517
0.12
0.0
0.752
0.975
6.9e-28
HCC70 Torin1 2
sigmoid
sigmoid
HCC70 Torin1 0 2
 9 1.573
0.0399
-0.322
0.653
0.107
-0.343
0.53
0.962
7.04e-25
0.123
0.183
0.557
0.0522
0.201
0.6
0.964
3.46e-25
HCC70 QL-VIII-58 1
sigmoid
sigmoid
HCC70 QL-VIII-58 0 1
 9 1.598
0.0739
-0.976
0.791
0.319
-1.0
0.752
0.972
4.08e-27
0.127
0.000989
0.519
0.127
0.0
0.723
0.981
6.68e-30
HCC70 Torin1 3
sigmoid
sigmoid
HCC70 Torin1 0 3
 9 1.750
0.0678
-0.133
0.547
0.0833
-0.0781
0.706
0.967
3.43e-25
0.133
0.232
0.596
0.0487
0.284
0.833
0.971
4.17e-26
HCC70 AZD8055 1
sigmoid
sigmoid
HCC70 AZD8055 0 1
 9 1.598
0.0382
0.0624
0.564
0.0292
0.0882
0.722
0.969
1.75e-26
0.158
0.364
0.601
0.0229
0.379
0.734
0.965
1.44e-25
HCC70 QL-V-107 2
sigmoid
sigmoid
HCC70 QL-V-107 0 2
 9 1.573
0.0752
-0.655
0.721
0.361
-0.895
0.653
0.99
7.55e-35
0.163
0.0632
0.541
0.163
0.0
0.682
0.987
1.08e-32
HCC1806 AZD8055 3
sigmoid
sigmoid
HCC1806 AZD8055 0 3
 9 2.697
0.249
0.382
0.325
0.0778
0.383
1.25
0.992
1.75e-36
0.177
0.369
0.652
0.061
0.37
1.26
0.992
2.49e-36
HCC70 QL-IV-100 2
sigmoid
sigmoid
HCC70 QL-IV-100 0 2
 9 1.573
0.0891
-0.75
0.716
0.451
-1.0
0.678
0.986
2.16e-32
0.18
0.0381
0.549
0.18
0.0
0.729
0.977
1.02e-28
HCC70 Torin1 1
sigmoid
sigmoid
HCC70 Torin1 0 1
 9 1.598
0.061
-0.147
0.573
0.0884
-0.134
0.64
0.954
1.68e-23
0.182
0.256
0.601
0.057
0.275
0.684
0.957
6.27e-24
HCC70 QL-V-107 1
sigmoid
sigmoid
HCC70 QL-V-107 0 1
 9 1.598
0.0994
-0.612
0.672
0.409
-0.834
0.694
0.988
3.47e-33
0.206
0.0727
0.566
0.206
0.0
0.712
0.984
4.79e-31
HCC70 QL-IV-100 3
sigmoid
sigmoid
HCC70 QL-IV-100 0 3
 9 1.750
0.129
-0.657
0.638
0.443
-0.822
0.786
0.989
2.41e-34
0.208
0.0458
0.575
0.208
0.0
0.819
0.985
1.33e-31
HCC70 QL-IV-100 1
sigmoid
sigmoid
HCC70 QL-IV-100 0 1
 9 1.598
0.115
-0.713
0.67
0.502
-0.951
0.723
0.992
2.58e-36
0.219
0.045
0.574
0.219
0.0
0.776
0.989
2.4e-34
HCC70 QL-V-107 3
sigmoid
sigmoid
HCC70 QL-V-107 0 3
 9 1.750
0.14
-0.593
0.616
0.414
-0.728
0.829
0.994
4.36e-39
0.227
0.0616
0.585
0.222
0.0103
0.847
0.991
1.33e-35
HCC1806 Torin1 3
sigmoid
sigmoid
HCC1806 Torin1 0 3
 9 2.697
0.393
0.144
0.339
0.25
0.145
0.753
0.972
4.9e-27
0.243
0.222
0.648
0.112
0.264
0.964
0.972
5.22e-27
HCC1806 QL-IV-100 3
sigmoid
sigmoid
HCC1806 QL-IV-100 0 3
 9 2.697
0.287
-0.301
0.472
0.412
-0.344
1.45
0.995
2.12e-39
0.252
0.0588
0.608
0.24
0.0305
1.31
0.992
2.13e-36
HCC1806 QL-VIII-58 2
sigmoid
sigmoid
HCC1806 QL-VIII-58 0 2
 9 2.714
0.377
-0.671
0.481
1.56
-1.0
0.773
0.938
2.91e-21
0.267
0.00748
0.596
0.267
0.0
0.778
0.895
2.46e-17
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