Evaluation of the sensitivity of two triple-negative breast cancer cell lines (HCC1806, HCC70) to a collection of dual mTOR and PI3K-like kinase (PIKK) inhibitors. Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivity of two triple-negative breast cancer cell lines (HCC1806, HCC70) to a collection of dual mTOR and PI3K-like kinase (PIKK) inhibitors. Dataset 2 of 2: GR metrics. - Dataset (ID:20367)

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Cell line	Drug name	Experimental replicate	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared curve fit (GR values)	P-value curve fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared curve fit (relative cell counts)	P-value curve fit (relative cell counts)
HCC70	QL-XII-47	1	sigmoid	sigmoid	HCC70 QL-XII-47 0 1	9	1.598	0.767	-0.806	0.406	1.22	-0.822	2.11	0.994	3.85e-38	0.971	0.0243	0.758	0.954	0.0199	2.33	0.989	7.52e-34
HCC1806	Torin1	1	sigmoid	sigmoid	HCC1806 Torin1 0 1	9	2.619	0.515	0.179	0.326	0.302	0.148	0.662	0.971	9.22e-27	0.347	0.251	0.66	0.129	0.272	0.796	0.975	8.08e-28
HCC1806	QL-V-107	1	sigmoid	sigmoid	HCC1806 QL-V-107 0 1	9	2.619	0.586	-0.315	0.383	1.03	-0.442	1.12	0.993	7.41e-38	0.53	0.0606	0.662	0.53	0.0	1.07	0.989	6.64e-34
HCC1806	QL-VIII-58	1	sigmoid	sigmoid	HCC1806 QL-VIII-58 0 1	9	2.619	0.471	-0.657	0.441	1.51	-0.961	0.923	0.997	8.08e-44	0.388	0.00996	0.645	0.388	0.0	1.08	0.993	3.33e-37
HCC1806	QL-XII-47	1	sigmoid	sigmoid	HCC1806 QL-XII-47 0 1	9	2.619	1.16	-0.581	0.307	1.74	-0.626	2.01	0.998	7.86e-47	1.09	0.0168	0.766	1.07	0.0132	2.48	0.995	5.29e-40
HCC1806	QL-XII-61	1	sigmoid	sigmoid	HCC1806 QL-XII-61 0 1	9	2.619	6.9	0.407	0.0291	5.14	0.386	5.0	0.962	5.78e-25	6.52	0.4	0.974	4.87	0.384	5.0	0.956	8.68e-24
HCC70	QL-VI-86	1	sigmoid	sigmoid	HCC70 QL-VI-86 0 1	9	1.598	0.299	-0.674	0.511	1.21	-1.0	0.786	0.987	7.69e-33	0.529	0.0552	0.668	0.529	0.0	0.854	0.981	5.86e-30
HCC1806	QL-IV-100	1	sigmoid	sigmoid	HCC1806 QL-IV-100 0 1	9	2.619	0.303	-0.286	0.47	0.414	-0.317	1.57	0.992	4.02e-36	0.274	0.0675	0.611	0.259	0.0348	1.29	0.99	8.31e-35
HCC1806	QL-V-73	1	sigmoid	sigmoid	HCC1806 QL-V-73 0 1	9	2.619	2.14	-0.175	0.21	3.86	-0.536	1.24	0.992	6.14e-36	1.95	0.0983	0.797	1.94	0.000723	1.36	0.981	6.21e-30
HCC1806	QL-VI-86	1	sigmoid	sigmoid	HCC1806 QL-VI-86 0 1	9	2.619	1.41	-0.214	0.244	2.16	-0.376	1.31	0.997	1.33e-44	1.28	0.0866	0.776	1.21	0.0401	1.42	0.995	1.89e-39
HCC1806	QL-X-138	1	sigmoid	sigmoid	HCC1806 QL-X-138 0 1	9	2.619	6.42	0.243	0.0784	13.0	-0.855	1.41	0.992	2.35e-36	5.79	0.288	0.918	5.79	0.0	1.63	0.987	1.31e-32
HCC1806	QL-XII-108	1	sigmoid	sigmoid	HCC1806 QL-XII-108 0 1	9	2.619	7.21	0.374	0.081	12.1	-0.403	1.15	0.986	2.16e-32	6.53	0.374	0.911	6.53	0.0	1.2	0.979	2.47e-29
HCC70	QL-V-107	1	sigmoid	sigmoid	HCC70 QL-V-107 0 1	9	1.598	0.0994	-0.612	0.672	0.409	-0.834	0.694	0.988	3.47e-33	0.206	0.0727	0.566	0.206	0.0	0.712	0.984	4.79e-31
HCC70	Torin2	1	sigmoid	sigmoid	HCC70 Torin2 0 1	9	1.598	0.014	-0.946	1.07	0.0747	-1.0	0.657	0.991	3.28e-35	0.0269	0.00323	0.362	0.0269	0.0	0.682	0.988	1.64e-33
HCC70	QL-VIII-58	1	sigmoid	sigmoid	HCC70 QL-VIII-58 0 1	9	1.598	0.0739	-0.976	0.791	0.319	-1.0	0.752	0.972	4.08e-27	0.127	0.000989	0.519	0.127	0.0	0.723	0.981	6.68e-30
HCC70	QL-IV-100	1	sigmoid	sigmoid	HCC70 QL-IV-100 0 1	9	1.598	0.115	-0.713	0.67	0.502	-0.951	0.723	0.992	2.58e-36	0.219	0.045	0.574	0.219	0.0	0.776	0.989	2.4e-34
HCC1806	AZD8055	1	sigmoid	sigmoid	HCC1806 AZD8055 0 1	9	2.619	0.478	0.384	0.305	0.0881	0.405	0.984	0.981	4.01e-29	0.322	0.382	0.673	0.0664	0.398	1.01	0.981	4.52e-29
HCC70	QL-X-138	1	sigmoid	sigmoid	HCC70 QL-X-138 0 1	9	1.598	1.41	-0.213	0.248	3.83	-0.724	0.893	0.983	5.84e-31	2.51	0.225	0.827	2.38	0.025	0.931	0.978	8.59e-29
HCC70	QL-V-73	1	sigmoid	sigmoid	HCC70 QL-V-73 0 1	9	1.598	0.538	-0.558	0.42	2.22	-1.0	0.774	0.987	5.03e-33	0.973	0.0898	0.716	0.973	0.0	0.812	0.98	1.98e-29
HCC70	QL-XII-61	1	sigmoid	sigmoid	HCC70 QL-XII-61 0 1	9	1.598	6.18	0.125	0.0875	11.5	-1.0	1.76	0.946	2.8e-22	8.07	0.399	0.937	8.07	0.0	1.9	0.932	1.35e-20
HCC70	QL-XII-108	1	sigmoid	sigmoid	HCC70 QL-XII-108 0 1	9	1.598	1.64	0.0903	0.226	2.06	-0.115	0.914	0.963	5.57e-25	3.65	0.379	0.836	1.5	0.287	0.962	0.954	1.98e-23
HCC70	AZD8055	1	sigmoid	sigmoid	HCC70 AZD8055 0 1	9	1.598	0.0382	0.0624	0.564	0.0292	0.0882	0.722	0.969	1.75e-26	0.158	0.364	0.601	0.0229	0.379	0.734	0.965	1.44e-25
HCC70	Torin1	1	sigmoid	sigmoid	HCC70 Torin1 0 1	9	1.598	0.061	-0.147	0.573	0.0884	-0.134	0.64	0.954	1.68e-23	0.182	0.256	0.601	0.057	0.275	0.684	0.957	6.27e-24
HCC1806	Torin2	1	sigmoid	sigmoid	HCC1806 Torin2 0 1	9	2.619	0.0655	-0.43	0.683	0.107	-0.389	1.17	0.994	7.49e-39	0.0584	0.0375	0.456	0.0546	0.0391	1.2	0.997	3.89e-44
HCC70	QL-VI-86	2	sigmoid	sigmoid	HCC70 QL-VI-86 0 2	9	1.573	0.266	-0.695	0.519	0.899	-0.926	0.861	0.989	1.06e-33	0.467	0.052	0.672	0.467	0.0	0.934	0.983	9.31e-31

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HMS LINCS Project

Evaluation of the sensitivity of two triple-negative breast cancer cell lines (HCC1806, HCC70) to a collection of dual mTOR and PI3K-like kinase (PIKK) inhibitors. Dataset 2 of 2: GR metrics. - Dataset (ID:20367)