Evaluation of the sensitivity of two triple-negative breast cancer cell lines (HCC1806, HCC70) to a collection of dual mTOR and PI3K-like kinase (PIKK) inhibitors. Dataset 2 of 2: GR metrics. - Dataset (ID:20367)
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| Cell line | Drug name | Experimental replicate | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared curve fit (GR values) | P-value curve fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared curve fit (relative cell counts) | P-value curve fit (relative cell counts) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | QL-XII-47 | 2 | sigmoid | sigmoid | HCC70 QL-XII-47 0 2 | 9 | 1.573 | 0.728 | -0.818 | 0.401 | 1.07 | -0.805 | 2.49 | 0.991 | 6.84e-36 | 0.901 | 0.0231 | 0.771 | 0.883 | 0.029 | 2.89 | 0.985 | 1.44e-31 |
| HCC70 | QL-XII-47 | 3 | sigmoid | sigmoid | HCC70 QL-XII-47 0 3 | 9 | 1.750 | 0.67 | -0.681 | 0.457 | 0.98 | -0.726 | 2.37 | 0.993 | 4e-37 | 0.776 | 0.0408 | 0.712 | 0.76 | 0.022 | 2.23 | 0.988 | 1.63e-33 |
| HCC70 | QL-XII-61 | 1 | sigmoid | sigmoid | HCC70 QL-XII-61 0 1 | 9 | 1.598 | 6.18 | 0.125 | 0.0875 | 11.5 | -1.0 | 1.76 | 0.946 | 2.8e-22 | 8.07 | 0.399 | 0.937 | 8.07 | 0.0 | 1.9 | 0.932 | 1.35e-20 |
| HCC70 | QL-XII-61 | 2 | sigmoid | sigmoid | HCC70 QL-XII-61 0 2 | 9 | 1.573 | 4.5 | 0.179 | 0.0498 | 4.14 | 0.169 | 5.0 | 0.928 | 3.35e-20 | 5.98 | 0.436 | 0.967 | 4.03 | 0.43 | 5.0 | 0.913 | 1.01e-18 |
| HCC70 | QL-XII-61 | 3 | sigmoid | sigmoid | HCC70 QL-XII-61 0 3 | 9 | 1.750 | 6.08 | 0.145 | 0.111 | 12.1 | -1.0 | 1.6 | 0.908 | 2.21e-18 | 7.62 | 0.377 | 0.913 | 7.62 | 0.0 | 1.76 | 0.879 | 2.58e-16 |
| HCC70 | Torin1 | 1 | sigmoid | sigmoid | HCC70 Torin1 0 1 | 9 | 1.598 | 0.061 | -0.147 | 0.573 | 0.0884 | -0.134 | 0.64 | 0.954 | 1.68e-23 | 0.182 | 0.256 | 0.601 | 0.057 | 0.275 | 0.684 | 0.957 | 6.27e-24 |
| HCC70 | Torin1 | 2 | sigmoid | sigmoid | HCC70 Torin1 0 2 | 9 | 1.573 | 0.0399 | -0.322 | 0.653 | 0.107 | -0.343 | 0.53 | 0.962 | 7.04e-25 | 0.123 | 0.183 | 0.557 | 0.0522 | 0.201 | 0.6 | 0.964 | 3.46e-25 |
| HCC70 | Torin1 | 3 | sigmoid | sigmoid | HCC70 Torin1 0 3 | 9 | 1.750 | 0.0678 | -0.133 | 0.547 | 0.0833 | -0.0781 | 0.706 | 0.967 | 3.43e-25 | 0.133 | 0.232 | 0.596 | 0.0487 | 0.284 | 0.833 | 0.971 | 4.17e-26 |
| HCC70 | Torin2 | 1 | sigmoid | sigmoid | HCC70 Torin2 0 1 | 9 | 1.598 | 0.014 | -0.946 | 1.07 | 0.0747 | -1.0 | 0.657 | 0.991 | 3.28e-35 | 0.0269 | 0.00323 | 0.362 | 0.0269 | 0.0 | 0.682 | 0.988 | 1.64e-33 |
| HCC70 | Torin2 | 2 | sigmoid | sigmoid | HCC70 Torin2 0 2 | 9 | 1.573 | 0.0124 | -0.955 | 1.11 | 0.0639 | -1.0 | 0.669 | 0.99 | 1.92e-34 | 0.0242 | 0.00262 | 0.351 | 0.0242 | 0.0 | 0.695 | 0.987 | 7.52e-33 |
| HCC70 | Torin2 | 3 | sigmoid | sigmoid | HCC70 Torin2 0 3 | 9 | 1.750 | 0.018 | -0.94 | 1.03 | 0.0947 | -1.0 | 0.661 | 0.992 | 2.34e-36 | 0.0285 | 0.00226 | 0.367 | 0.0285 | 0.0 | 0.704 | 0.99 | 4.9e-35 |
| HCC1806 | AZD8055 | 1 | sigmoid | sigmoid | HCC1806 AZD8055 0 1 | 9 | 2.619 | 0.478 | 0.384 | 0.305 | 0.0881 | 0.405 | 0.984 | 0.981 | 4.01e-29 | 0.322 | 0.382 | 0.673 | 0.0664 | 0.398 | 1.01 | 0.981 | 4.52e-29 |
| HCC1806 | AZD8055 | 2 | sigmoid | sigmoid | HCC1806 AZD8055 0 2 | 9 | 2.714 | 0.738 | 0.43 | 0.289 | 0.094 | 0.437 | 1.01 | 0.947 | 2.1e-22 | 0.387 | 0.402 | 0.678 | 0.0732 | 0.405 | 0.999 | 0.935 | 6.08e-21 |
| HCC1806 | AZD8055 | 3 | sigmoid | sigmoid | HCC1806 AZD8055 0 3 | 9 | 2.697 | 0.249 | 0.382 | 0.325 | 0.0778 | 0.383 | 1.25 | 0.992 | 1.75e-36 | 0.177 | 0.369 | 0.652 | 0.061 | 0.37 | 1.26 | 0.992 | 2.49e-36 |
| HCC1806 | QL-IV-100 | 1 | sigmoid | sigmoid | HCC1806 QL-IV-100 0 1 | 9 | 2.619 | 0.303 | -0.286 | 0.47 | 0.414 | -0.317 | 1.57 | 0.992 | 4.02e-36 | 0.274 | 0.0675 | 0.611 | 0.259 | 0.0348 | 1.29 | 0.99 | 8.31e-35 |
| HCC1806 | QL-IV-100 | 2 | sigmoid | sigmoid | HCC1806 QL-IV-100 0 2 | 9 | 2.714 | 0.334 | -0.269 | 0.453 | 0.46 | -0.309 | 1.51 | 0.992 | 8.44e-37 | 0.292 | 0.065 | 0.615 | 0.28 | 0.0247 | 1.22 | 0.99 | 8.24e-35 |
| HCC1806 | QL-IV-100 | 3 | sigmoid | sigmoid | HCC1806 QL-IV-100 0 3 | 9 | 2.697 | 0.287 | -0.301 | 0.472 | 0.412 | -0.344 | 1.45 | 0.995 | 2.12e-39 | 0.252 | 0.0588 | 0.608 | 0.24 | 0.0305 | 1.31 | 0.992 | 2.13e-36 |
| HCC1806 | QL-V-107 | 1 | sigmoid | sigmoid | HCC1806 QL-V-107 0 1 | 9 | 2.619 | 0.586 | -0.315 | 0.383 | 1.03 | -0.442 | 1.12 | 0.993 | 7.41e-38 | 0.53 | 0.0606 | 0.662 | 0.53 | 0.0 | 1.07 | 0.989 | 6.64e-34 |
| HCC1806 | QL-V-107 | 2 | sigmoid | sigmoid | HCC1806 QL-V-107 0 2 | 9 | 2.714 | 0.604 | -0.279 | 0.364 | 1.09 | -0.428 | 1.05 | 0.995 | 5.69e-40 | 0.517 | 0.0629 | 0.672 | 0.517 | 0.0 | 1.02 | 0.994 | 2.98e-38 |
| HCC1806 | QL-V-107 | 3 | sigmoid | sigmoid | HCC1806 QL-V-107 0 3 | 9 | 2.697 | 0.519 | -0.346 | 0.402 | 1.01 | -0.489 | 1.03 | 0.965 | 1.52e-25 | 0.443 | 0.0491 | 0.645 | 0.435 | 0.00946 | 1.1 | 0.932 | 1.36e-20 |
| HCC1806 | QL-V-73 | 1 | sigmoid | sigmoid | HCC1806 QL-V-73 0 1 | 9 | 2.619 | 2.14 | -0.175 | 0.21 | 3.86 | -0.536 | 1.24 | 0.992 | 6.14e-36 | 1.95 | 0.0983 | 0.797 | 1.94 | 0.000723 | 1.36 | 0.981 | 6.21e-30 |
| HCC1806 | QL-V-73 | 2 | sigmoid | sigmoid | HCC1806 QL-V-73 0 2 | 9 | 2.714 | 2.24 | -0.136 | 0.192 | 3.69 | -0.452 | 1.28 | 0.994 | 5.74e-39 | 1.96 | 0.102 | 0.813 | 1.92 | 0.016 | 1.41 | 0.989 | 3.06e-34 |
| HCC1806 | QL-V-73 | 3 | sigmoid | sigmoid | HCC1806 QL-V-73 0 3 | 9 | 2.697 | 1.96 | -0.197 | 0.215 | 3.3 | -0.482 | 1.29 | 0.994 | 6.63e-39 | 1.72 | 0.0855 | 0.793 | 1.68 | 0.0165 | 1.44 | 0.989 | 5.05e-34 |
| HCC1806 | QL-VI-86 | 1 | sigmoid | sigmoid | HCC1806 QL-VI-86 0 1 | 9 | 2.619 | 1.41 | -0.214 | 0.244 | 2.16 | -0.376 | 1.31 | 0.997 | 1.33e-44 | 1.28 | 0.0866 | 0.776 | 1.21 | 0.0401 | 1.42 | 0.995 | 1.89e-39 |
| HCC1806 | QL-VI-86 | 3 | sigmoid | sigmoid | HCC1806 QL-VI-86 0 3 | 9 | 2.697 | 1.31 | -0.229 | 0.248 | 2.19 | -0.42 | 1.2 | 0.994 | 4.5e-38 | 1.11 | 0.0766 | 0.771 | 1.02 | 0.0546 | 1.46 | 0.987 | 5.18e-33 |