Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)

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Cell Small Molecule Treatment Duration GR50 GRmax GR_AOC GEC50 GRinf hGR
Hs 578T Doxycycline 72
inf
 1.3436 -0.0222 0.0000 1.0000 0.0100
BT-20 STK547622 72
inf
 1.1526 -0.0532 0.0000 1.0000 0.0100
BT-20 IU1 72
inf
 1.1490 -0.1850 0.0000 1.0000 0.0100
MDA-MB-134-VI 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 1.1199 0.1894 0.0000 0.8466 0.0100
HCC1500 z-VAE(OMe)-fmk 72
inf
 1.1021 0.0136 0.0000 1.0000 0.0100
MDA-MB-361 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 1.0999 0.0175 0.0000 1.0000 0.0100
PDX1258 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 1.0981 0.0141 0.0000 0.9940 0.0100
PDX1328 Doxycycline 72
inf
 1.0834 0.0387 0.0000 0.9720 0.0100
HCC1500 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 1.0783 0.0024 0.0000 0.9998 0.0100
HCC1419 STK547622 72
inf
 1.0781 0.0128 0.0000 1.0000 0.0100
PDX1258 GW7647 72
inf
 1.0702 -0.0651 0.0000 1.0000 0.0100
PDX1328 z-VAE(OMe)-fmk 72
inf
 1.0551 0.0297 0.0000 0.9884 0.0100
MDA-MB-231 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 1.0514 0.0482 0.0000 0.9659 0.0100
HCC1954 z-VAE(OMe)-fmk 72
inf
 1.0513 0.0385 0.0000 0.9751 0.0100
MDA-MB-361 STK547622 72
inf
 1.0471 -0.1279 0.0000 1.0000 0.0100
BT-20 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 1.0460 0.0369 0.0000 0.9732 0.0100
PDX1328 SB1-F-22 72
inf
 1.0347 -0.2404 0.0000 1.0000 0.0100
HCC1937 STK547622 72
inf
 1.0316 -0.0512 0.0000 1.0000 0.0100
Hs 578T 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 1.0210 0.0119 0.0000 0.9987 0.0100
MCF7 STK547622 72
inf
 1.0181 -0.0093 0.0000 1.0000 0.0100
MCF7 z-VAE(OMe)-fmk 72
inf
 1.0118 -0.0177 0.0000 1.0000 0.0100
BT-20 HY-17542 72
inf
 1.0099 -0.0181 0.0000 1.0000 0.0100
HCC202 z-VAE(OMe)-fmk 72
inf
 1.0085 0.0421 0.0000 0.9739 0.0100
MCF7 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 1.0084 -0.0062 0.0000 1.0000 0.0100
MCF 10A STK547622 72
inf
 1.0022 -0.0053 0.0000 1.0000 0.0100
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