Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| PDXHCI002 | 1247825-37-1 | 72 | 7.7918126167 | -0.2501 | 0.2337 | 8.8742 | -0.2609 | 3.2282 |
| HCC1428 | 1247825-37-1 | 72 | 4.93495492588 | -0.2477 | 0.3384 | 6.4761 | -0.2632 | 1.5561 |
| MDA-MB-134-VI | 1247825-37-1 | 72 | 10.4154396199 | -0.1095 | 0.2026 | 10.7700 | -0.0911 | 5.0000 |
| PDX1328 | 1247825-37-1 | 72 | 22.1349466658 | -0.4424 | 0.1065 | 25.3891 | -0.4927 | 5.0000 |
| HCC1500 | 1247825-37-1 | 72 | 9.28838157031 | -0.3852 | 0.2439 | 10.3909 | -0.3761 | 5.0000 |
| Hs 578T | 1247825-37-1 | 72 | 10.9138626563 | -0.3555 | 0.2306 | 11.9637 | -0.2914 | 5.0000 |
| MCF 10A | 1247825-37-1 | 72 | 7.50677192458 | -0.0271 | 0.2339 | 7.8926 | -0.0577 | 2.1809 |
| MCF7 | 1247825-37-1 | 72 | 11.3527817708 | -0.0635 | 0.1793 | 13.0348 | -0.1527 | 1.9288 |
| MDA-MB-231 | 1247825-37-1 | 72 | 11.4936019115 | -0.0918 | 0.1830 | 11.8477 | -0.0819 | 5.0000 |
| PDX1258 | 1247825-37-1 | 72 | 13.2811411655 | 0.1210 | 0.0958 | 12.5137 | 0.1287 | 5.0000 |
| SK-BR-3 | 1247825-37-1 | 72 | 8.5852333914 | -0.0647 | 0.2610 | 8.9503 | -0.0631 | 2.8528 |
| T47D | 1247825-37-1 | 72 | 11.5296139364 | -0.2221 | 0.1900 | 12.3560 | -0.2068 | 5.0000 |
| CAMA-1 | 1247825-37-1 | 72 | 12.5263467336 | -0.2434 | 0.1646 | 13.4850 | -0.2229 | 5.0000 |
| HCC1419 | 1247825-37-1 | 72 | 11.9633348293 | -0.2267 | 0.1675 | 13.1469 | -0.2174 | 3.8271 |
| BT-20 | 1247825-37-1 | 72 | 10.843923028 | -0.5078 | 0.1707 | 13.0472 | -0.4829 | 3.6541 |
| HCC202 | 1247825-37-1 | 72 | 8.82600510672 | -0.3858 | 0.1854 | 10.8343 | -0.3618 | 2.6557 |
| HCC1937 | 1247825-37-1 | 72 | 13.156649451 | 0.0110 | 0.1377 | 13.6093 | -0.0392 | 2.2330 |
| BT-549 | 1247825-37-1 | 72 | 13.5700541273 | -0.0465 | 0.1614 | 13.9726 | -0.0577 | 3.7355 |
| HCC1954 | 1247825-37-1 | 72 | 9.27208726827 | -0.2049 | 0.2775 | 11.2541 | -0.2697 | 2.2268 |
| HCC1806 | 1247825-37-1 | 72 | 9.12829214245 | -0.2678 | 0.2475 | 11.9984 | -0.3697 | 2.0245 |
| MDA-MB-361 | 1247825-37-1 | 72 | 13.2255127818 | -0.4648 | 0.1648 | 21.0813 | -0.7304 | 1.9314 |
| HCC1500 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 1.0783 | 0.0024 | 0.0000 | 0.9998 | 0.0100 |
| MCF 10A | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | 738.9217363 | 0.8943 | 0.0150 | 255.4365 | 0.3311 | 1.0216 |
| Hs 578T | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 1.0210 | 0.0119 | 0.0000 | 0.9987 | 0.0100 |
| HCC202 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 0.7899 | 0.0919 | 0.0000 | 0.9166 | 0.0100 |