Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| BT-20 | 1247825-37-1 | 72 | 10.843923028 | -0.5078 | 0.1707 | 13.0472 | -0.4829 | 3.6541 |
| BT-20 | USP7-IN-1 | 72 | 67.2869814403 | 0.7451 | 0.0229 | 80.6417 | -0.3763 | 3.0994 |
| BT-20 | GW7647 | 72 | inf | 0.7093 | -0.0625 | 0.0000 | 1.0000 | 0.0100 |
| BT-20 | HBX19818 | 72 | 30.8921915642 | -0.2433 | 0.0631 | 35.1813 | -0.4578 | 5.0000 |
| BT-20 | HBX 41108 | 72 | 0.575869637316 | -0.5895 | 0.6999 | 1.0838 | -0.5642 | 1.1945 |
| BT-20 | HY-17541A | 72 | 9.75522426236 | -0.8815 | 0.3328 | 13.7782 | -0.9458 | 3.0751 |
| BT-20 | HY-17542 | 72 | inf | 1.0099 | -0.0181 | 0.0000 | 1.0000 | 0.0100 |
| BT-20 | HY-50736 | 72 | 0.154452624267 | -0.4430 | 0.9442 | 0.2491 | -0.5003 | 1.4504 |
| BT-20 | HY-50737A | 72 | 0.556969018793 | -0.5469 | 0.6980 | 0.9349 | -0.5102 | 1.3577 |
| BT-20 | IU1 | 72 | inf | 1.1490 | -0.1850 | 0.0000 | 1.0000 | 0.0100 |
| BT-20 | LDN57444 | 72 | 0.273589049961 | -0.5384 | 0.7238 | 0.4768 | -0.3750 | 1.0074 |
| BT-20 | MI-2 | 72 | 0.409633050522 | -0.7406 | 0.9227 | 0.6203 | -0.7720 | 2.2499 |
| BT-20 | ML-323 | 72 | 211.396631725 | 0.7311 | 0.0653 | 1563.4058 | -1.0000 | 0.5491 |
| BT-20 | Pevonedistat | 72 | 0.777542936783 | -0.2693 | 0.5455 | 0.9974 | -0.2189 | 1.4577 |
| BT-20 | PB49673382 | 72 | 3.13374675059 | 0.0918 | 0.3024 | 2.9808 | 0.1107 | 5.0000 |
| BT-20 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 1.0460 | 0.0369 | 0.0000 | 0.9732 | 0.0100 |
| BT-20 | SB1-F-21 | 72 | 0.696988451088 | -0.7116 | 0.7843 | 0.8263 | -0.6712 | 5.0000 |
| BT-20 | SB1-F-22 | 72 | inf | 0.8486 | -0.0325 | 0.0000 | 1.0000 | 0.0100 |
| BT-20 | SJB2-043 | 72 | 0.626589137637 | -0.6216 | 0.5257 | 0.7914 | -0.6048 | 3.3941 |
| BT-20 | SJB3-019A | 72 | 0.340138717913 | -0.6009 | 0.8217 | 0.3987 | -0.6067 | 5.0000 |
| BT-20 | STK547622 | 72 | inf | 1.1526 | -0.0532 | 0.0000 | 1.0000 | 0.0100 |
| BT-20 | Vialinin A | 72 | 5.11668603811 | -0.6101 | 0.3004 | 9.2727 | -0.7177 | 1.4971 |
| BT-20 | Degrasyn | 72 | 1.87496854329 | -0.6371 | 0.6302 | 2.2190 | -0.6608 | 5.0000 |
| BT-20 | Sepantronium | 72 | 0.00899052444777 | -0.5379 | 1.5452 | 0.0105 | -0.5979 | 5.0000 |
| BT-20 | b-AP15 | 72 | 0.164472498608 | -0.6967 | 1.0402 | 0.2405 | -0.6510 | 2.1937 |