Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| PDXHCI002 | Mitoxantrone | 72 | 0.000170736912028 | -0.5642 | 1.3538 | 0.0014 | -0.5519 | 0.3578 |
| MDA-MB-231 | Mitoxantrone | 72 | 0.000221543574526 | -0.5445 | 1.2292 | 0.0275 | -0.8714 | 0.2093 |
| Hs 578T | Mitoxantrone | 72 | 0.00035868699252 | -0.6845 | 1.3575 | 0.0152 | -0.8850 | 0.2720 |
| BT-20 | Mitoxantrone | 72 | 0.00114283548045 | -0.8192 | 1.3912 | 0.0267 | -0.9144 | 0.3300 |
| MDA-MB-134-VI | Mitoxantrone | 72 | 0.00179578357498 | -0.9383 | 1.6042 | 0.0182 | -1.0000 | 0.4745 |
| MDA-MB-361 | Mitoxantrone | 72 | 0.00180293182659 | -0.9488 | 1.4412 | 0.0357 | -1.0000 | 0.3678 |
| MDA-MB-231 | Sepantronium | 72 | 0.00234663809275 | -0.3665 | 1.2531 | 0.0040 | -0.3210 | 0.9233 |
| HCC1428 | Mitoxantrone | 72 | 0.00295749777894 | -0.6226 | 1.3027 | 0.0198 | -0.6386 | 0.4326 |
| HCC202 | Mitoxantrone | 72 | 0.00434457297625 | -0.7112 | 1.2184 | 0.1443 | -1.0000 | 0.3136 |
| CAMA-1 | Sepantronium | 72 | 0.00492479486482 | -0.5726 | 1.4926 | 0.0065 | -0.5275 | 2.5831 |
| CAMA-1 | Mitoxantrone | 72 | 0.0062993374498 | -0.8126 | 1.3228 | 0.0295 | -0.6695 | 0.5504 |
| HCC1428 | Sepantronium | 72 | 0.00658980680929 | -0.7607 | 1.4822 | 0.0245 | -0.7925 | 0.7235 |
| HCC1428 | HY-50736 | 72 | 0.00717425961123 | -0.6124 | 1.6421 | 0.0111 | -0.7153 | 2.0173 |
| CAMA-1 | HY-50736 | 72 | 0.00740329650359 | -0.4438 | 1.4260 | 0.0096 | -0.4747 | 2.5511 |
| PDX1258 | Mitoxantrone | 72 | 0.007407644519 | -0.6933 | 1.1643 | 0.2222 | -1.0000 | 0.3230 |
| MCF 10A | Sepantronium | 72 | 0.00774537160659 | -0.1459 | 1.0865 | 0.0087 | -0.1294 | 1.9809 |
| SK-BR-3 | Mitoxantrone | 72 | 0.00831816680715 | -0.7263 | 1.2354 | 0.0647 | -0.7477 | 0.4458 |
| MCF7 | Sepantronium | 72 | 0.00846233647125 | -0.3440 | 1.2181 | 0.0126 | -0.3282 | 1.2567 |
| PDX1258 | HY-50736 | 72 | 0.0087703068144 | -0.3555 | 1.4216 | 0.0121 | -0.3791 | 1.7398 |
| BT-20 | Sepantronium | 72 | 0.00899052444777 | -0.5379 | 1.5452 | 0.0105 | -0.5979 | 5.0000 |
| HCC1954 | Sepantronium | 72 | 0.0107560548807 | -0.7271 | 1.4585 | 0.0156 | -0.4591 | 1.7448 |
| HCC1500 | Mitoxantrone | 72 | 0.0111833408416 | -0.4904 | 1.0596 | 0.0246 | -0.2899 | 0.5795 |
| HCC1954 | Mitoxantrone | 72 | 0.0141773373515 | -0.6799 | 1.1790 | 0.1017 | -0.7312 | 0.4574 |
| MCF7 | Mitoxantrone | 72 | 0.0169144908308 | -0.7736 | 1.0817 | 0.3991 | -1.0000 | 0.3475 |
| HCC1937 | HY-50736 | 72 | 0.0175748900813 | -0.4737 | 1.2706 | 0.0315 | -0.5040 | 1.1960 |