Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| PDX1328 | SB1-F-21 | 72 | 0.844936773852 | -0.9869 | 0.7625 | 1.8713 | -1.0000 | 1.3817 |
| PDX1328 | Trifluoperazine | 72 | 10.4012800704 | -0.9795 | 0.3652 | 12.9427 | -0.9916 | 5.0000 |
| PDX1328 | SJB3-019A | 72 | 0.117013699533 | -0.9745 | 1.3027 | 0.1897 | -0.9715 | 2.2348 |
| PDX1328 | HY-17541A | 72 | 6.04754155289 | -0.9724 | 0.3564 | 13.0481 | -1.0000 | 1.4286 |
| PDX1328 | Sepantronium | 72 | 0.0218983386219 | -0.9670 | 1.5930 | 0.0347 | -0.5708 | 1.6579 |
| PDX1328 | Mitoxantrone | 72 | 0.0227860417414 | -0.9642 | 1.3672 | 0.1228 | -1.0000 | 0.6522 |
| PDX1328 | SJB2-043 | 72 | 0.283039978056 | -0.9550 | 0.9369 | 0.3776 | -0.9607 | 3.7191 |
| PDX1328 | P22077 | 72 | 8.67568163015 | -0.9510 | 0.3247 | 12.1205 | -0.9858 | 3.2572 |
| PDX1328 | HBX19818 | 72 | 13.6607133025 | -0.9490 | 0.3096 | 19.8613 | -1.0000 | 2.9355 |
| MDA-MB-361 | Mitoxantrone | 72 | 0.00180293182659 | -0.9488 | 1.4412 | 0.0357 | -1.0000 | 0.3678 |
| MDA-MB-134-VI | Mitoxantrone | 72 | 0.00179578357498 | -0.9383 | 1.6042 | 0.0182 | -1.0000 | 0.4745 |
| MDA-MB-134-VI | HY-17541A | 72 | 7.95461844294 | -0.9278 | 0.2754 | 16.0755 | -1.0000 | 1.5615 |
| PDX1328 | b-AP15 | 72 | 0.183369061603 | -0.9168 | 1.1450 | 0.2761 | -0.8858 | 2.4900 |
| PDX1328 | MI-2 | 72 | 5.25760821785 | -0.9161 | 0.4330 | 6.4858 | -0.9284 | 5.0000 |
| PDX1328 | Degrasyn | 72 | 2.23838869532 | -0.9056 | 0.6219 | 3.3568 | -0.9207 | 2.5770 |
| PDX1328 | Pimozide | 72 | 9.51211170773 | -0.8995 | 0.2585 | 11.6946 | -0.9045 | 5.0000 |
| HCC1419 | Mitoxantrone | 72 | 0.0324309949523 | -0.8993 | 1.0606 | 0.5551 | -1.0000 | 0.3868 |
| PDX1328 | HY-50737A | 72 | 0.2644727784 | -0.8890 | 1.0078 | 0.4995 | -0.8567 | 1.5697 |
| BT-20 | HY-17541A | 72 | 9.75522426236 | -0.8815 | 0.3328 | 13.7782 | -0.9458 | 3.0751 |
| MDA-MB-134-VI | Trifluoperazine | 72 | 9.80158936254 | -0.8785 | 0.3335 | 11.9699 | -0.8413 | 4.9377 |
| HCC202 | Trifluoperazine | 72 | 10.0332245014 | -0.8634 | 0.3175 | 14.5499 | -0.9578 | 2.8790 |
| PDX1328 | HBX 41108 | 72 | 0.252282958678 | -0.8598 | 0.9493 | 0.8725 | -0.9529 | 0.8597 |
| MDA-MB-361 | HY-17541A | 72 | 8.08778635864 | -0.8457 | 0.3036 | 20.0570 | -1.0000 | 1.2096 |
| HCC1954 | HY-17541A | 72 | 4.05518549047 | -0.8364 | 0.4858 | 9.2414 | -1.0000 | 1.3338 |
| MDA-MB-134-VI | Sepantronium | 72 | 0.188092865815 | -0.8332 | 0.9138 | 0.6637 | -0.8337 | 0.7781 |