Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | THZ531 | 0.403782298 | -0.4375 | 0.1475 | 0.6623 | -1.0000 | 2.2199 | 0.9948 | 1.11e-16 |
| Hs 578T | THZ531 | 0.048528081 | -0.2670 | 0.3750 | 0.0565 | -0.2217 | 2.4067 | 0.9945 | 1.11e-16 |
| MCF 10A | THZ531 | 0.357116458529 | -0.6687 | 0.1492 | 0.5711 | -1.0000 | 2.3402 | 0.9921 | 1.11022302463e-16 |
| MCF 10A | Alvocidib | 0.099467899 | -0.4802 | 0.3475 | 0.1398 | -0.5288 | 2.1178 | 0.9920 | 1.11e-16 |
| Hs 578T | Alvocidib | 0.148558558 | -0.2518 | 0.2560 | 0.2079 | -0.3548 | 1.5955 | 0.9912 | 1.11e-16 |
| Hs 578T | THZ1 | 0.018250125 | -0.4195 | 0.5223 | 0.0232 | -0.3000 | 1.9491 | 0.9905 | 1.11e-16 |
| MCF 10A | THZ1 | 0.046492791 | -0.4253 | 0.4095 | 0.1201 | -0.6388 | 0.8674 | 0.9905 | 1.11e-16 |
| BT-549 | Alvocidib | 0.161331919984 | -0.4334 | 0.2463 | 0.3134 | -0.7128 | 1.3342 | 0.9894 | 1.11022302463e-16 |
| HCC1143 | Alvocidib | 0.171201738 | -0.3370 | 0.2245 | 0.2832 | -0.5220 | 1.4205 | 0.9893 | 1.11e-16 |
| SUM149PT | THZ1 | 0.048963473 | -0.4879 | 0.4000 | 0.0794 | -0.4676 | 1.3644 | 0.9885 | 1.11e-16 |
| HCC1143 | THZ1 | 0.026504565 | -0.2975 | 0.4699 | 0.0315 | -0.2909 | 2.6729 | 0.9872 | 1.11e-16 |
| MCF 10A | BMS-265246 | 0.454251489017 | 0.0186 | 0.3954 | 6.2231 | -0.7970 | 0.3642 | 0.9860 | 1.11022302463e-16 |
| BT-20 | Alvocidib | 0.109020751309 | -0.6023 | 0.3436 | 0.2983 | -1.0000 | 1.0915 | 0.9859 | 1.11022302463e-16 |
| HCC1806 | Alvocidib | 0.165238718298 | -0.4850 | 0.2588 | 0.4377 | -1.0000 | 1.1279 | 0.9859 | 1.11022302463e-16 |
| HME1 | Alvocidib | 0.114196744 | -0.3549 | 0.3125 | 0.4526 | -1.0000 | 0.7978 | 0.9854 | 1.11e-16 |
| BT-549 | THZ531 | 0.288722955947 | -0.3189 | 0.1797 | 0.5487 | -0.8192 | 1.5112 | 0.9852 | 1.11022302463e-16 |
| HCC70 | Alvocidib | 0.0750808131344 | -0.8534 | 0.4131 | 0.1347 | -0.9337 | 1.8026 | 0.9849 | 1.11022302463e-16 |
| MCF 10A | RO-3306 | 5.973258525 | -0.0959 | 0.0874 | 9.3379 | -1.0000 | 2.4589 | 0.9848 | 1.11e-16 |
| MDA-MB-231 | THZ1 | 0.0637722395519 | -0.4824 | 0.3383 | 0.1459 | -0.6653 | 1.0222 | 0.9846 | 1.11022302463e-16 |
| MCF 10A | AZD6738 | 9.21613673637 | 0.4291 | 0.0314 | 16.0807 | -0.9996 | 1.9730 | 0.9840 | 1.11022302463e-16 |
| SUM159PT | Alvocidib | 0.135046848 | -0.0857 | 0.2341 | 0.1695 | -0.1659 | 1.2608 | 0.9830 | 1.11e-16 |
| MCF 10A | AZD6738 | 6.530884217 | 0.1820 | 0.0788 | 12.1220 | -1.0000 | 1.7763 | 0.9830 | 1.11e-16 |
| SUM149PT | THZ531 | 0.351886206 | -0.4909 | 0.1494 | 0.5549 | -0.8336 | 2.1536 | 0.9830 | 1.11e-16 |
| HCC38 | THZ1 | 0.02382594 | -0.5420 | 0.5167 | 0.0405 | -0.4828 | 1.2756 | 0.9829 | 1.11e-16 |
| HCC1143 | THZ531 | 0.129709951 | -0.2293 | 0.2435 | 0.1509 | -0.2433 | 2.6173 | 0.9825 | 1.11e-16 |