Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| BT-20 | AZD6738 | 5.68190940846 | 0.1069 | -0.0571 | 5.4098 | 0.1088 | 5.0000 | 0.8298 | 2.43821740575e-10 |
| BT-20 | RO-3306 | 5.05230087025 | -0.2878 | 0.1099 | 5.5833 | -0.3241 | 5.0000 | 0.9562 | 1.11022302463e-16 |
| MDA-MB-361 | THZ531 | 0.027601073 | -0.5305 | 0.6318 | 0.0328 | -0.6914 | 5.0000 | 0.9478 | 1.11e-16 |
| SK-BR-3 | GSK2334470 | inf | 0.1727 | 0.3229 | 0.0048 | 0.6054 | 5.0000 | 0.3843 | 0.002330067 |
| T47D | THZ531 | 0.113575449 | -0.1534 | 0.2161 | 0.1189 | -0.1295 | 5.0000 | 0.9624 | 1.11e-16 |
| SK-BR-3 | Rucaparib | inf | 0.7324 | 0.1120 | 0.0074 | 0.8618 | 5.0000 | 0.2180 | 0.046276083 |
| MDA-MB-157 | AZD6738 | 8.215702739 | -0.0514 | -0.2134 | 10.2346 | -1.0000 | 5.0000 | 0.3830 | 0.000671245 |
| MDA-MB-361 | Ulixertinib | 0.487697861 | 0.0501 | 0.2106 | 0.3084 | 0.4494 | 5.0000 | 0.6060 | 8.79e-06 |
| MDA-MB-361 | Rucaparib | inf | 0.1133 | 0.3149 | 0.0128 | 0.5095 | 5.0000 | 0.3359 | 0.005993375 |
| MDA-MB-157 | Ribociclib | inf | 0.5908 | 0.0808 | 0.0790 | 0.8320 | 5.0000 | 0.2263 | 0.040460682 |
| MDA-MB-436 | RO-3306 | 4.603680516 | 0.0322 | 0.0603 | 4.5391 | 0.0341 | 5.0000 | 0.8979 | 4.12e-13 |
| HCC38 | RO-3306 | 7.435051917 | -0.2110 | 0.0493 | 9.2621 | -1.0000 | 5.0000 | 0.9513 | 1.11e-16 |
| HCC1428 | GSK2334470 | 0.261068206 | 0.2500 | 0.4172 | 0.2322 | 0.2218 | 5.0000 | 0.2993 | 0.01172251 |
| HCC1395 | SHP099 | inf | 0.5184 | 0.0927 | 5.0946 | 0.5377 | 5.0000 | 0.4367 | 0.000766633 |
| AU565 | AZD6738 | 9.117192222 | 0.2755 | 0.0564 | 11.3576 | -1.0000 | 5.0000 | 0.7383 | 5.27e-08 |
| CAL-120 | SHP099 | 13.63352074 | 0.7924 | 0.0042 | 16.9837 | -1.0000 | 5.0000 | 0.4392 | 0.000724955 |
| HME1 | AZD6738 | 5.825895792 | 0.2920 | 0.0055 | 4.9604 | 0.2763 | 5.0000 | 0.8741 | 5.61e-12 |
| MDA-MB-157 | RO-3306 | 4.277636246 | -0.4568 | 0.0971 | 4.8761 | -0.4623 | 5.0000 | 0.8859 | 1.65e-12 |
| HME1 | RO-3306 | 4.087843972 | -0.0172 | 0.0517 | 4.0640 | 0.0144 | 5.0000 | 0.9574 | 1.11e-16 |
| CAL-120 | RO-3306 | 8.527233934 | 0.1534 | 0.0250 | 10.6226 | -1.0000 | 5.0000 | 0.9423 | 3.33e-16 |
| HCC1937 | Rucaparib | inf | 0.7658 | 0.0636 | 0.0095 | 0.8675 | 5.0000 | 0.2293 | 0.038523875 |
| CAMA-1 | Rucaparib | inf | 0.8528 | 0.1254 | 0.0108 | 0.8301 | 5.0000 | 0.2588 | 0.023653062 |
| HCC1419 | RO-3306 | 8.899414267 | 0.2237 | 0.0089 | 11.0863 | -1.0000 | 5.0000 | 0.7309 | 7.48e-08 |
| HCC1954 | AZD6738 | 5.21852308366 | 0.1138 | -0.0199 | 5.0338 | 0.0824 | 5.0000 | 0.8519 | 4.27073931775e-11 |
| HCC1806 | RO-3306 | 5.34198338119 | -0.1128 | 0.0801 | 5.6376 | -0.1545 | 5.0000 | 0.9818 | 1.11022302463e-16 |