Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
MB 157
Unknown
Unknown
 GSK1838705A
IGF1R
RTK
7482.091
uM
inf
0.15366
 0.4980 0.6154 5.0000 0.2226
0.7803
 1.9368
MB 157
Unknown
Unknown
 GSK1838705A
IGF1R
RTK
7482.098
uM
13.1410
25.90460
 -0.6844 -1.0000 1.6187 0.2372
0.9646
 2.2478
MB 157
Unknown
Unknown
 Ibandronate
FDPS
12580.143
uM
136.3470
396.08660
 -0.6113 -1.0000 1.0302 0.2335
0.9936
 2.2318
MB 157
Unknown
Unknown
 ICRF-193
TOP2
TOP
12580.171
uM
inf
6.10730
 0.6967 0.6039 0.6807 0.0598
0.9693
 2.0272
MB 157
Unknown
Unknown
 Imatinib
ABL/KIT/PDGFR
nRTK
7482.091
uM
21.96750
32.89250
 -0.9235 -0.9157 2.5782 0.4301
0.9918
 1.9368
MB 157
Unknown
Unknown
 Ispinesib
KSP
Kinesin
7482.067
uM
0.01035
0.01271
 -0.9081 -0.7477 4.4646 1.0951
0.9672
 1.9350
MB 157
Unknown
Unknown
 Ixabepilone
TUBB
TUBB
7482.095
uM
0.00650
0.01010
 -0.8414 -0.5486 1.6781 0.9670
0.9725
 2.2108
MB 157
Unknown
Unknown
 JNK-IN-5A
JNK
JNK
12580.168
uM
140.86720
212.72740
 0.1400 -0.8586 2.4251 0.1014
0.9615
 2.0973
MB 157
Unknown
Unknown
 L-779450
BRAF
MAPK
12580.166
uM
10.15030
9.16750
 0.1997 0.1984 4.9629 0.0310
0.9777
 1.8686
MB 157
Unknown
Unknown
 Lapatinib
EGFR/HER2
ErbB
7482.098
uM
inf
0.84860
 0.5818 0.5588 1.3649 0.1246
0.9576
 2.2478
MB 157
Unknown
Unknown
 LBH589
HDAC
HDAC
12580.167
uM
0.09791
0.21279
 -0.7184 -0.7419 1.1720 0.6807
0.9985
 2.1970
MB 157
Unknown
Unknown
 Lestaurtinib
FLT3/JAK2/TrkA
RTK
12580.167
uM
1.19390
2.9160
 -0.5705 -0.7086 0.9884 0.3296
0.9978
 2.1970
MB 157
Unknown
Unknown
 Methotrexate
DHFR
Metabolism
7482.084
uM
0.00739
0.00686
 0.1498 0.1549 5.0000 0.6920
0.9484
 1.8697
MB 157
Unknown
Unknown
 MG-132
Proteasome
Proteasome
12580.17
uM
0.21638
0.29557
 -0.7447 -0.7340 2.8965 0.7295
0.9997
 1.9993
MB 157
Unknown
Unknown
 MG-132
Proteasome
Proteasome
12580.17
uM
0.21638
0.29557
 -0.7447 -0.7340 2.8965 0.7295
0.9997
 1.9993
MB 157
Unknown
Unknown
 Pevonedistat
NAE1
NAE1
12580.135
uM
0.30216
0.24681
 0.1102 0.1338 1.5384 0.3784
0.9967
 2.1782
MB 157
Unknown
Unknown
 Nilotinib
ABL
nRTK
12580.17
uM
inf
inf
 0.8681 0.8681 0.0000 -0.0263
0.5610
 1.9993
MB 157
Unknown
Unknown
 NSC 663284
CDC25
CDC
12580.152
uM
1.98170
2.38630
 -0.7558 -0.7659 5.0000 0.5664
0.9993
 2.2597
MB 157
Unknown
Unknown
 NU6102
CDK1/2
CDK
12580.147
uM
15.12290
15.03190
 0.0154 0.0149 4.9987 0.0904
0.9945
 2.2358
MB 157
Unknown
Unknown
 Nutlin 3a
MDM2
MDM2
7482.066
uM
19.4010
19.74440
 -0.0414 -0.0443 4.8390 0.0474
0.9858
 1.1347
MB 157
Unknown
Unknown
 Olomoucine II
CDK1
CDK
12580.147
uM
6.63190
6.67680
 -0.0300 -0.0171 4.9968 0.2096
0.9975
 2.2358
MB 157
Unknown
Unknown
 Oxamflatin
HDAC
HDAC
12580.147
uM
0.85570
2.17280
 -0.7159 -0.7630 0.9944 0.4721
0.9998
 2.2358
MB 157
Unknown
Unknown
 PD 98059
MEK
MAPK
12580.152
uM
inf
13.27340
 0.8145 0.8142 4.7549 0.0130
0.9491
 2.2597
MB 157
Unknown
Unknown
 PD184352
MEK
MAPK
12580.155
uM
18.04330
65.47820
 0.2734 -1.0000 0.8523 0.1204
0.9309
 2.2315
MB 157
Unknown
Unknown
 PD184352
MEK
MAPK
12580.155
uM
18.04330
65.47820
 0.2734 -1.0000 0.8523 0.1204
0.9309
 2.2315