Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | NM | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14215.189 | uM | 0.19306 | 0.33832 | -0.5358 | -0.5384 | 1.3027 | 0.6413 | 0.9941 | 3.3654 | |
| MCF 10A | NM | Basal B | ZM-447439 | AURK | AURK | 11056.15 | uM | inf | 0.46426 | 0.6809 | 0.6831 | 2.5666 | 0.1026 | 0.9909 | 3.0207 | |
| MCF 10F | NM | - | (Z)-4-Hydroxytamoxifen | ESR1 | 9566.132 | uM | inf | inf | 0.8030 | 0.8030 | 0.0000 | 0.1021 | 0.1442 | 2.4013 | ||
| MCF 10F | NM | - | (Z)-4-Hydroxytamoxifen | ESR1 | 7488.016 | uM | inf | inf | 0.7328 | 0.7328 | 0.0000 | 0.0898 | 0.5484 | 1.2238 | ||
| MCF 10F | NM | - | (Z)-4-Hydroxytamoxifen | ESR1 | 7871.016 | uM | inf | 34.66260 | 0.8429 | 0.8429 | 4.9988 | -0.0104 | 0.6376 | 1.0272 | ||
| MCF 10F | NM | - | (Z)-4-Hydroxytamoxifen | ESR1 | 7872.016 | uM | 7.35710 | 5.64830 | 0.1459 | 0.2589 | 2.7594 | 0.2512 | 0.8956 | 1.4834 | ||
| MCF 10F | NM | - | 17-AAG | HSP90 | HSP90 | 9566.037 | uM | 0.02204 | 0.02960 | -0.6811 | -0.4104 | 2.0316 | 0.8581 | 0.9734 | 2.3981 | |
| MCF 10F | NM | - | 17-AAG | HSP90 | HSP90 | 7872.05 | uM | 0.05381 | 0.07251 | -0.6743 | -0.4438 | 2.1310 | 0.7870 | 0.9773 | 1.4902 | |
| MCF 10F | NM | - | 17-AAG | HSP90 | HSP90 | 7488.05 | uM | 0.03331 | 0.04908 | -0.6479 | -0.6520 | 2.1534 | 0.9911 | 0.9931 | 1.3218 | |
| MCF 10F | NM | - | 17-AAG | HSP90 | HSP90 | 7871.05 | uM | 0.03306 | 0.04763 | -0.6716 | -0.6276 | 2.2263 | 0.9743 | 0.9978 | 1.2892 | |
| MCF 10F | NM | - | 5-DFUR | TYMS | TYMS | 12254.143 | uM | 63.3380 | 706.87470 | -0.1749 | -0.7057 | 0.3649 | 0.3869 | 0.9817 | 1.4110 | |
| MCF 10F | NM | - | 5-FU | TYMS | TYMS | 7872.017 | uM | inf | inf | 1.0126 | 1.0126 | 0.0000 | 0.1656 | 0.1751 | 1.5155 | |
| MCF 10F | NM | - | 5-FU | TYMS | TYMS | 9566.017 | uM | inf | inf | -0.5228 | -0.5228 | 0.0000 | 0.9440 | 0.5049 | 2.1734 | |
| MCF 10F | NM | - | Afatinib | EGFR/HER2 | ErbB | 12254.165 | uM | 0.14488 | 1.2310 | -0.9038 | -1.0000 | 0.5134 | 0.6500 | 0.9482 | 1.6980 | |
| MCF 10F | NM | - | AG1024 | IGF1R | RTK | 7487.066 | uM | 3.16780 | 3.58670 | -0.2159 | -0.2180 | 2.9137 | 0.2458 | 0.9890 | 1.5845 | |
| MCF 10F | NM | - | AG1024 | IGF1R | RTK | 7486.066 | uM | 6.10380 | 6.67550 | -0.2819 | -0.2824 | 5.0000 | 0.1371 | 0.9935 | 1.0443 | |
| MCF 10F | NM | - | AG1478 | EGFR | ErbB | 7871.016 | uM | 0.26822 | 0.61294 | -0.7528 | -0.4319 | 0.7534 | 0.5760 | 0.9143 | 1.0272 | |
| MCF 10F | NM | - | AG1478 | EGFR | ErbB | 7872.016 | uM | 0.18152 | 0.17521 | -0.1284 | 0.0354 | 2.0740 | 0.5174 | 0.9676 | 1.4834 | |
| MCF 10F | NM | - | AG1478 | EGFR | ErbB | 7488.016 | uM | 0.13005 | 0.18318 | -0.5014 | -0.3822 | 1.6575 | 0.7346 | 0.9867 | 1.2238 | |
| MCF 10F | NM | - | AS-252424 | PI3K | PI3K | 12254.165 | uM | inf | 7.11430 | 0.5640 | 0.5638 | 4.9952 | 0.0226 | 0.9503 | 1.6980 | |
| MCF 10F | NM | - | Baicalein | Lipoxygenase | Metabolism | 7486.072 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0295 | -0.4179 | 1.0885 | |
| MCF 10F | NM | - | Baicalein | Lipoxygenase | Metabolism | 12254.072 | uM | inf | inf | 0.9615 | 0.9615 | 0.0000 | 0.0021 | 0.0460 | 1.9429 | |
| MCF 10F | NM | - | Bortezomib | Proteasome | Proteasome | 14751.203 | uM | 0.00760 | 0.02274 | -0.7561 | -0.6964 | 0.7957 | 1.0581 | 0.9771 | 1.8391 | |
| MCF 10F | NM | - | Bortezomib | Proteasome | Proteasome | 14751.203 | uM | 0.00760 | 0.02274 | -0.7561 | -0.6964 | 0.7957 | 1.0581 | 0.9771 | 1.8391 | |
| MCF 10F | NM | - | Bortezomib | Proteasome | Proteasome | 15319.203 | uM | 0.25752 | 1.08520 | -0.6660 | -0.8305 | 0.6804 | 0.6021 | 0.9885 | 2.2432 |