Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10F | NM | - | Bortezomib | Proteasome | Proteasome | 15319.203 | uM | 0.25752 | 1.08520 | -0.6660 | -0.8305 | 0.6804 | 0.6021 | 0.9885 | 2.2432 | |
| MCF 10F | NM | - | Bortezomib | Proteasome | Proteasome | 7487.074 | uM | 0.14698 | 0.69853 | -0.9095 | -0.9810 | 0.6967 | 0.8500 | 0.9984 | 1.4197 | |
| MCF 10F | NM | - | Bortezomib | Proteasome | Proteasome | 7487.074 | uM | 0.14698 | 0.69853 | -0.9095 | -0.9810 | 0.6967 | 0.8500 | 0.9984 | 1.4197 | |
| MCF 10F | NM | - | Bosutinib | Src | nRTK | 12254.145 | uM | 1.74970 | 1.42480 | 0.1378 | 0.1430 | 1.6396 | 0.2593 | 0.9896 | 1.7869 | |
| MCF 10F | NM | - | Carboplatin | DNA cross-linker | DNA cross-linker | 9566.011 | uM | 50.05840 | 101.28940 | -0.7823 | -0.8360 | 1.3945 | 0.3717 | 0.9990 | 2.3358 | |
| MCF 10F | NM | - | Cetuximab | EGFR | ErbB | 7871.018 | uM | inf | inf | 0.9011 | 0.9011 | 0.0000 | -0.0407 | -0.0154 | 1.1973 | |
| MCF 10F | NM | - | Cetuximab | EGFR | ErbB | 7872.042 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0054 | -0.0002 | 1.3632 | |
| MCF 10F | NM | - | Cetuximab | EGFR | ErbB | 9566.026 | uM | inf | 0.82410 | 0.8674 | 0.5338 | 5.0000 | -0.0169 | 0.5906 | 2.1367 | |
| MCF 10F | NM | - | Cetuximab | EGFR | ErbB | 7487.102 | uM | 1.06250 | 14.53060 | 0.5584 | -1.0000 | 0.4200 | 0.0918 | 0.9670 | 1.5273 | |
| MCF 10F | NM | - | CGC-11047 | Polyamine analogue | 7871.018 | uM | 47.070 | 357.34540 | -0.9407 | -1.0000 | 0.5420 | 0.5234 | 0.8721 | 1.1973 | ||
| MCF 10F | NM | - | CGC-11047 | Polyamine analogue | 9566.026 | uM | 528.70890 | 925.43090 | -0.8038 | -0.8874 | 1.8230 | 0.3767 | 0.9064 | 2.1367 | ||
| MCF 10F | NM | - | Cisplatin | DNA cross-linker | DNA cross-linker | 7872.017 | uM | inf | inf | 1.0147 | 1.0147 | 0.0000 | 0.0576 | 0.1865 | 1.5155 | |
| MCF 10F | NM | - | Cisplatin | DNA cross-linker | DNA cross-linker | 9566.017 | uM | 4.6420 | 12.04970 | -0.8879 | -0.9634 | 1.1258 | 0.4811 | 0.9925 | 2.1734 | |
| MCF 10F | NM | - | CPT-11 | TOP1 | TOP | 7488.078 | uM | 6.62120 | 145.43530 | 0.0707 | -1.0000 | 0.3556 | 0.2851 | 0.8922 | 1.5130 | |
| MCF 10F | NM | - | CPT-11 | TOP1 | TOP | 9566.121 | uM | 11.98630 | 9.85590 | 0.2040 | 0.0709 | 0.7813 | 0.1541 | 0.9856 | 2.3089 | |
| MCF 10F | NM | - | CPT-11 | TOP1 | TOP | 7872.007 | uM | 6.86330 | 50.68290 | -0.1196 | -1.0000 | 0.5495 | 0.2254 | 0.9895 | 1.7126 | |
| MCF 10F | NM | - | Dactolisib | PI3K | PI3K | 12254.155 | uM | inf | inf | 0.7426 | 0.7426 | 0.0000 | 0.2566 | 0.4622 | 1.8150 | |
| MCF 10F | NM | - | Dichloroacetate | PDK | PDK | 13750.176 | uM | inf | inf | 0.8474 | 0.8474 | 0.0000 | 0.0585 | 0.2166 | 1.5387 | |
| MCF 10F | NM | - | Disulfiram | Proteasome | Proteasome | 13750.174 | uM | inf | inf | 0.7281 | 0.7281 | 0.0000 | 0.1301 | 0.5378 | 1.4282 | |
| MCF 10F | NM | - | Docetaxel | TUBB | TUBB | 9566.002 | uM | 0.00310 | 0.00266 | 0.1697 | 0.1139 | 1.6809 | 0.5687 | 0.9785 | 2.0986 | |
| MCF 10F | NM | - | Doxorubicin | TOP2 | TOP | 7872.007 | uM | inf | inf | -0.9824 | -0.9824 | 0.0000 | 0.6025 | 0.4814 | 1.7126 | |
| MCF 10F | NM | - | Doxorubicin | TOP2 | TOP | 7488.078 | uM | 0.16076 | 0.55032 | -0.8135 | -0.8936 | 0.8329 | 0.7776 | 0.9798 | 1.5130 | |
| MCF 10F | NM | - | Doxorubicin | TOP2 | TOP | 9566.121 | uM | 0.64040 | 1.03820 | -0.7383 | -0.7411 | 1.8818 | 0.6289 | 0.9914 | 2.3089 | |
| MCF 10F | NM | - | Epirubicin | TOP2 | TOP | 7872.017 | uM | inf | inf | 0.9560 | 0.9560 | 0.0000 | 0.0576 | 0.1221 | 1.5155 | |
| MCF 10F | NM | - | Epirubicin | TOP2 | TOP | 9566.017 | uM | 0.48103 | 0.96882 | -0.8799 | -0.8046 | 1.3697 | 0.7144 | 0.9971 | 2.1734 |