Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MB 157 | Unknown | Unknown | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7482.095 | uM | 0.45491 | 0.21241 | 0.3008 | 0.2970 | 1.1838 | 0.5367 | 0.9244 | 2.2108 | |
| MB 157 | Unknown | Unknown | PS-1145 | IKK | NFKB | 7482.065 | uM | inf | inf | 0.9413 | 0.9413 | 0.0000 | 0.0141 | 0.0523 | 2.2390 | |
| MB 157 | Unknown | Unknown | Purvalanol A | CDK1 | CDK | 7482.067 | uM | 1.75670 | 1.74740 | 0.1498 | 0.0132 | 5.0000 | 0.4222 | 0.7450 | 1.9350 | |
| MB 157 | Unknown | Unknown | SB-3CT | MMP2/9 | MMP | 12580.168 | uM | inf | 999.49420 | 0.9016 | 0.7834 | 0.1339 | 0.0552 | 0.5863 | 2.0973 | |
| MB 157 | Unknown | Unknown | Selumetinib | MEK | MAPK | 12580.155 | uM | 0.26308 | 0.08392 | 0.2460 | 0.2091 | 0.4742 | 0.3920 | 0.9920 | 2.2315 | |
| MB 157 | Unknown | Unknown | Sigma A6730 | AKT | AKT | 12580.165 | uM | 13.33510 | 15.84260 | -0.6815 | -0.6828 | 4.9970 | 0.1959 | 0.9769 | 2.2883 | |
| MB 157 | Unknown | Unknown | Sirolimus | MTOR | MTOR | 9039.068 | uM | inf | inf | 0.0730 | 0.0730 | 0.0000 | 0.5500 | 0.5032 | 0.4510 | |
| MB 157 | Unknown | Unknown | Sirolimus | MTOR | MTOR | 7482.069 | uM | inf | 0.02594 | 0.7163 | 0.7222 | 1.5641 | 0.1554 | 0.9762 | 2.1744 | |
| MB 157 | Unknown | Unknown | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7482.084 | uM | inf | inf | 1.0106 | 1.0106 | 0.0000 | -0.0449 | -13.5536 | 1.8697 | |
| MB 157 | Unknown | Unknown | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7482.067 | uM | 3.83970 | 8.99340 | -0.9514 | -1.0000 | 1.2908 | 0.5341 | 0.9614 | 1.9350 | |
| MB 157 | Unknown | Unknown | TCS 2312 | CHK1 | CHK | 12580.152 | uM | 0.39369 | 0.40867 | -0.1760 | -0.1026 | 5.0000 | 0.3574 | 0.9921 | 2.2597 | |
| MB 157 | Unknown | Unknown | TCS PIM-1 1 | Pim kinase | PIM | 12580.135 | uM | inf | 150.77040 | 0.8333 | 0.5221 | 4.9812 | -0.0078 | 0.7813 | 2.1782 | |
| MB 157 | Unknown | Unknown | Temsirolimus | MTOR | MTOR | 12580.168 | uM | 0.52601 | 19.98360 | -0.6679 | -1.0000 | 0.3020 | 0.5025 | 0.8114 | 2.0973 | |
| MB 157 | Unknown | Unknown | Topotecan | TOP1 | TOP | 9039.078 | uM | 0.00994 | 0.03355 | -0.9969 | -1.0000 | 0.9028 | 1.2872 | 0.9855 | 0.6306 | |
| MB 157 | Unknown | Unknown | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 12580.169 | uM | 0.08297 | 0.09563 | -0.5824 | -0.3198 | 3.4823 | 0.6951 | 0.9733 | 2.1524 | |
| MB 157 | Unknown | Unknown | Trametinib | MEK | MAPK | 9039.05 | uM | 0.01120 | 0.01040 | -0.2387 | 0.0220 | 0.6061 | 0.5364 | 0.7586 | 0.4285 | |
| MB 157 | Unknown | Unknown | Trichostatin A | HDAC | HDAC | 7482.065 | uM | 10.20190 | 17.41690 | -0.7553 | -0.7354 | 1.6912 | 0.7724 | 0.9990 | 2.2390 | |
| MB 157 | Unknown | Unknown | Triciribine | AKT | AKT | 7482.074 | uM | 2.67840 | 317.77670 | 0.2035 | -1.0000 | 0.2300 | 0.2827 | 0.6689 | 1.7663 | |
| MB 157 | Unknown | Unknown | Valproic acid | HDAC | HDAC | 12580.143 | uM | 3111.8610 | 999.99970 | 0.1758 | 0.3973 | 1.3940 | 0.0819 | 0.7946 | 2.2318 | |
| MB 157 | Unknown | Unknown | Vorinostat | HDAC | HDAC | 7482.065 | uM | 103.49220 | 292.37470 | -0.7311 | -0.7760 | 0.9021 | 0.5820 | 0.9995 | 2.2390 | |
| MB 157 | Unknown | Unknown | XRP44X | ELK3 | MAPK | 12580.171 | uM | 1.35870 | 1.36780 | -0.0074 | -0.0072 | 2.1297 | 0.3610 | 0.9996 | 2.0272 | |
| MB 157 | Unknown | Unknown | ZM-447439 | AURK | AURK | 12580.169 | uM | 0.75556 | 0.81963 | -0.3346 | -0.2512 | 5.0000 | 0.3762 | 0.9926 | 2.1524 | |
| MCF 10A | NM | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 9551.132 | uM | inf | inf | 0.8030 | 0.8030 | 0.0000 | 0.0980 | 0.1523 | 2.8612 | ||
| MCF 10A | NM | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7870.016 | uM | 136.89090 | 165.87320 | 0.0816 | -0.8061 | 5.0000 | 0.0251 | 0.9788 | 2.1045 | ||
| MCF 10A | NM | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7867.016 | uM | 26.1280 | 31.13250 | -0.7005 | -0.7009 | 5.0000 | 0.2035 | 0.9964 | 2.2657 |