Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | TPCA-1 | IKK | NFKB | 7472.1 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0330 | -0.2408 | 1.1120 | |
| Hs 578T | TNBC | Basal B | TPCA-1 | IKK | NFKB | 10379.093 | uM | 15.65710 | 1.95190 | 0.4404 | 0.4720 | 1.3845 | 0.1405 | 0.9856 | 2.2706 | |
| Hs 578T | TNBC | Basal B | Trametinib | MEK | MAPK | 7863.05 | uM | 0.22184 | 0.09437 | 0.2856 | 0.3450 | 1.3701 | 0.2740 | 0.9639 | 1.6873 | |
| Hs 578T | TNBC | Basal B | Trametinib | MEK | MAPK | 9511.012 | uM | 0.02885 | 0.01318 | 0.1225 | 0.2127 | 0.7074 | 0.4218 | 0.9651 | 1.2568 | |
| Hs 578T | TNBC | Basal B | Trametinib | MEK | MAPK | 7862.036 | uM | 0.01585 | 0.01929 | -0.3313 | -0.2156 | 1.8220 | 0.6474 | 0.9710 | 1.2405 | |
| Hs 578T | TNBC | Basal B | Trametinib | MEK | MAPK | 7864.05 | uM | 0.04564 | 0.04914 | -0.0647 | -0.0462 | 1.1952 | 0.4596 | 0.9903 | 1.5353 | |
| Hs 578T | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 7475.065 | uM | 21.88310 | 40.07690 | -0.8577 | -0.6795 | 1.4184 | 0.5950 | 0.9826 | 2.6262 | |
| Hs 578T | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 7473.065 | uM | 24.82330 | 58.32320 | -0.7517 | -0.7031 | 1.0279 | 0.5623 | 0.9846 | 2.7686 | |
| Hs 578T | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 7474.065 | uM | 12.51970 | 27.53870 | -0.8230 | -0.7140 | 1.1254 | 0.7081 | 0.9867 | 2.9702 | |
| Hs 578T | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 7472.065 | uM | 26.75980 | 40.49660 | -0.9962 | -0.9491 | 2.5682 | 0.6945 | 0.9966 | 0.9830 | |
| Hs 578T | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 10379.065 | uM | 35.86980 | 42.74940 | -0.7030 | -0.7021 | 4.9997 | 0.6074 | 0.9985 | 2.2436 | |
| Hs 578T | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 7471.065 | uM | 15.69150 | 22.51560 | -0.7402 | -0.7330 | 2.4996 | 0.7284 | 0.9995 | 2.2733 | |
| Hs 578T | TNBC | Basal B | Triciribine | AKT | AKT | 7473.074 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0187 | -0.0877 | 2.5364 | |
| Hs 578T | TNBC | Basal B | Triciribine | AKT | AKT | 7472.074 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0523 | -0.0595 | 1.5922 | |
| Hs 578T | TNBC | Basal B | Triciribine | AKT | AKT | 7474.074 | uM | inf | 3.54150 | 0.8416 | 0.8448 | 4.9283 | -0.0117 | 0.7209 | 2.6218 | |
| Hs 578T | TNBC | Basal B | Triciribine | AKT | AKT | 7475.074 | uM | inf | 7.68190 | 0.8352 | 0.8351 | 4.9107 | -0.0051 | 0.7507 | 2.4793 | |
| Hs 578T | TNBC | Basal B | Valproic acid | HDAC | HDAC | 10694.143 | uM | 2700.87510 | 1000.00000 | 0.0999 | 0.3449 | 1.1779 | 0.1288 | 0.7213 | 2.2259 | |
| Hs 578T | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 7863.018 | uM | 0.00274 | 0.00887 | -0.7408 | -0.5295 | 0.6149 | 0.9777 | 0.9225 | 2.0946 | |
| Hs 578T | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 7861.018 | uM | 0.04897 | 0.0580 | -0.9140 | -0.6652 | 5.0000 | 0.8697 | 0.9838 | 0.8485 | |
| Hs 578T | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 7864.042 | uM | 0.05162 | 0.06116 | -0.8667 | -0.6669 | 5.0000 | 0.8573 | 0.9850 | 1.4812 | |
| Hs 578T | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 7862.042 | uM | 0.00207 | 0.00477 | -0.9459 | -0.7850 | 1.1301 | 1.2549 | 0.9864 | 1.2756 | |
| Hs 578T | TNBC | Basal B | Vorinostat | HDAC | HDAC | 7473.065 | uM | 548.29430 | 1000.00000 | -0.6076 | -0.5339 | 1.2089 | 0.3263 | 0.9756 | 2.7686 | |
| Hs 578T | TNBC | Basal B | Vorinostat | HDAC | HDAC | 7472.065 | uM | 663.73890 | 912.55130 | -0.8308 | -0.8133 | 3.0335 | 0.4285 | 0.9793 | 0.9830 | |
| Hs 578T | TNBC | Basal B | Vorinostat | HDAC | HDAC | 7474.065 | uM | 326.70210 | 576.8770 | -0.6003 | -0.5551 | 1.3135 | 0.4292 | 0.9805 | 2.9702 | |
| Hs 578T | TNBC | Basal B | Vorinostat | HDAC | HDAC | 7475.065 | uM | 355.70880 | 604.97780 | -0.5960 | -0.6335 | 1.5411 | 0.4368 | 0.9939 | 2.6262 |