Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 7475.067 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0408 | -9.2547 | 2.4078 | |
| Hs 578T | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 7473.067 | uM | inf | inf | 0.9516 | 0.9516 | 0.0000 | -0.0284 | -0.2407 | 2.6736 | |
| Hs 578T | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 7474.067 | uM | inf | inf | 0.7787 | 0.7787 | 0.0000 | -0.0154 | 0.1964 | 2.7442 | |
| Hs 578T | TNBC | Basal B | Ribavirin | 15352.211 | uM | inf | inf | 0.9699 | 0.9699 | 0.0000 | -0.0304 | -0.7752 | 2.5357 | |||
| Hs 578T | TNBC | Basal B | SB-3CT | MMP2/9 | MMP | 10694.144 | uM | 30.17320 | 28.2630 | 0.1399 | 0.1382 | 4.9470 | 0.0296 | 0.9760 | 2.1636 | |
| Hs 578T | TNBC | Basal B | Selumetinib | MEK | MAPK | 10694.146 | uM | 40.77980 | 30.94250 | 0.4689 | 0.0654 | 0.5078 | 0.1117 | 0.9790 | 2.2821 | |
| Hs 578T | TNBC | Basal B | Sigma A6730 | AKT | AKT | 10694.153 | uM | 14.9020 | 25.71640 | -0.7493 | -1.0000 | 2.0135 | 0.1776 | 0.9967 | 2.2940 | |
| Hs 578T | TNBC | Basal B | Sirolimus | MTOR | MTOR | 7474.069 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0115 | -0.0565 | 2.5606 | |
| Hs 578T | TNBC | Basal B | Sirolimus | MTOR | MTOR | 7473.069 | uM | inf | inf | 0.9657 | 0.9657 | 0.0000 | 0.0026 | 0.0000 | 3.2103 | |
| Hs 578T | TNBC | Basal B | Sirolimus | MTOR | MTOR | 7475.069 | uM | inf | inf | 0.9609 | 0.9609 | 0.0000 | 0.0540 | 0.2883 | 2.7183 | |
| Hs 578T | TNBC | Basal B | Sirolimus | MTOR | MTOR | 7861.068 | uM | inf | 0.01657 | 0.6677 | 0.7424 | 5.0000 | 0.1662 | 0.8378 | 1.5554 | |
| Hs 578T | TNBC | Basal B | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7475.084 | uM | inf | 228.94580 | 0.7420 | 0.7418 | 4.9998 | -0.0088 | 0.8449 | 2.7804 | |
| Hs 578T | TNBC | Basal B | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7473.084 | uM | 1210.01560 | 999.18010 | 0.6509 | 0.3033 | 4.8722 | -0.0111 | 0.8989 | 2.0337 | |
| Hs 578T | TNBC | Basal B | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7474.084 | uM | 474.21380 | 590.74280 | -0.8699 | -1.0000 | 5.0000 | 0.1198 | 0.9846 | 2.6631 | |
| Hs 578T | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7473.067 | uM | 7.10170 | 8.68080 | -0.8838 | -0.8632 | 4.9954 | 0.4373 | 0.9845 | 2.6736 | |
| Hs 578T | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7474.067 | uM | 5.45640 | 8.59690 | -0.8618 | -0.9023 | 2.2684 | 0.4409 | 0.9946 | 2.7442 | |
| Hs 578T | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7475.067 | uM | 5.38430 | 7.34630 | -0.8808 | -0.8873 | 3.2844 | 0.4639 | 0.9981 | 2.4078 | |
| Hs 578T | TNBC | Basal B | Taxol | TUBB | TUBB | 7864.002 | uM | 0.00409 | 0.00803 | -0.5125 | -0.4792 | 0.9967 | 0.9577 | 0.9913 | 1.5910 | |
| Hs 578T | TNBC | Basal B | Taxol | TUBB | TUBB | 9511.002 | uM | 0.00407 | 0.00628 | -0.6889 | -0.5691 | 1.7559 | 1.0292 | 0.9934 | 1.1960 | |
| Hs 578T | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 10694.152 | uM | 0.92247 | 1.72570 | -0.4983 | -0.5189 | 1.1366 | 0.3570 | 0.9949 | 2.4238 | |
| Hs 578T | TNBC | Basal B | TCS PIM-1 1 | Pim kinase | PIM | 10694.148 | uM | inf | inf | 0.7268 | 0.7268 | 0.0000 | 0.0766 | 0.5658 | 2.4626 | |
| Hs 578T | TNBC | Basal B | Temsirolimus | MTOR | MTOR | 10694.144 | uM | 32.21280 | 53.07380 | -0.7824 | -1.0000 | 2.2002 | 0.2318 | 0.9539 | 2.1636 | |
| Hs 578T | TNBC | Basal B | Topotecan | TOP1 | TOP | 7863.007 | uM | 19.50830 | 171.5730 | 0.0548 | -1.0000 | 0.5053 | 0.1773 | 0.9480 | 1.4578 | |
| Hs 578T | TNBC | Basal B | Torkinib | 15352.211 | uM | 0.09021 | 0.26878 | -0.3566 | -0.4047 | 0.5431 | 0.5802 | 0.9760 | 2.5357 | |||
| Hs 578T | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10694.15 | uM | 0.52547 | 1.86090 | -0.3324 | -0.5170 | 0.5615 | 0.3657 | 0.9595 | 2.2191 |