Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
HCC70
TNBC
Basal A
 Vinorelbine
TUBB
TUBB
7860.042
uM
0.00826
0.00909
 -0.9878 -0.3086 5.0000 0.8621
0.8125
 0.6736
HCC70
TNBC
Basal A
 Vinorelbine
TUBB
TUBB
7857.042
uM
0.04107
0.06738
 -0.9430 -0.4842 1.3680 0.7808
0.8303
 1.1910
HCC70
TNBC
Basal A
 Vinorelbine
TUBB
TUBB
7856.018
uM
0.00565
0.00647
 -0.9839 -0.4765 4.9575 0.9820
0.9141
 0.9388
HCC70
TNBC
Basal A
 Vorinostat
HDAC
HDAC
7470.065
uM
33.25730
74.89780
 -0.9845 -1.0000 1.3532 0.8596
0.9994
 1.0127
HCC70
TNBC
Basal A
 XRP44X
ELK3
MAPK
12400.157
uM
0.94327
0.59188
 0.4621 0.2944 1.9070 0.3649
0.6498
 1.1935
HCC70
TNBC
Basal A
 XRP44X
ELK3
MAPK
10873.151
uM
1.03430
1.12210
 -0.4376 -0.2511 4.9995 0.4722
0.9541
 1.1786
HCC70
TNBC
Basal A
 Z-Leu-Leu-Norvalinal
Proteasome
Proteasome
14257.189
uM
0.14006
0.18556
 -1.0000 -1.0000 3.9051 0.9874
0.9714
 0.3775
HCC70
TNBC
Basal A
 ZM-447439
AURK
AURK
12400.169
uM
1.11250
1.22350
 -0.3407 -0.1309 2.4440 0.4028
0.9234
 1.2449
HCC70
TNBC
Basal A
 ZM-447439
AURK
AURK
10873.15
uM
1.14590
0.89832
 0.1529 0.2620 3.0488 0.1976
0.9686
 1.1958
HMT-3522 S1
Unknown
Unknown
 (Z)-4-Hydroxytamoxifen
ESR1
7911.016
uM
1.39530
1.68420
 -0.8555 -0.7809 4.9988 0.6089
0.9964
 1.3310
HMT-3522 S1
Unknown
Unknown
 17-AAG
HSP90
HSP90
7911.05
uM
0.09655
0.09094
 -0.0075 0.1294 5.0000 0.4613
0.9811
 1.7938
HMT-3522 S1
Unknown
Unknown
 5-FU
TYMS
TYMS
7911.017
uM
171.27690
862.56090
 -0.4058 -0.7064 0.5448 0.4588
0.9804
 1.6151
HMT-3522 S1
Unknown
Unknown
 AG1478
EGFR
ErbB
7911.016
uM
0.05852
0.05795
 -0.0237 0.0241 4.9968 0.6004
0.9865
 1.3310
HMT-3522 S1
Unknown
Unknown
 Carboplatin
DNA cross-linker
DNA cross-linker
10124.021
uM
51.86030
57.95620
 -0.5030 -0.3715 4.9989 0.3602
0.9724
 1.9744
HMT-3522 S1
Unknown
Unknown
 Carboplatin
DNA cross-linker
DNA cross-linker
7911.011
uM
48.34180
57.48450
 -0.8108 -0.6888 5.0000 0.3994
0.9880
 1.6150
HMT-3522 S1
Unknown
Unknown
 Cetuximab
EGFR
ErbB
7911.018
uM
0.02673
0.01835
 0.1964 0.1241 0.7579 0.2589
0.9901
 1.8543
HMT-3522 S1
Unknown
Unknown
 CGC-11047
Polyamine analogue
7911.018
uM
31.66120
737.39010
 -0.7780 -1.0000 0.3490 0.4782
0.7543
 1.8543
HMT-3522 S1
Unknown
Unknown
 CGC-11047
Polyamine analogue
10124.034
uM
13.48260
1000.00000
 -0.3617 -0.8757 0.2350 0.5029
0.7902
 2.2594
HMT-3522 S1
Unknown
Unknown
 Cisplatin
DNA cross-linker
DNA cross-linker
7911.017
uM
6.0870
8.58220
 -0.5846 -0.4132 1.7534 0.3852
0.9586
 1.6151
HMT-3522 S1
Unknown
Unknown
 Cisplatin
DNA cross-linker
DNA cross-linker
10124.021
uM
2.90770
3.62460
 -0.2450 -0.1698 1.3264 0.4038
0.9807
 1.9744
HMT-3522 S1
Unknown
Unknown
 CPT-11
TOP1
TOP
7911.007
uM
inf
80.38810
 0.8089 0.5178 4.9256 -0.0226
0.6581
 1.5549
HMT-3522 S1
Unknown
Unknown
 CPT-11
TOP1
TOP
10124.034
uM
14.05860
13.76860
 0.0497 0.0495 5.0000 0.1347
0.9805
 2.2594
HMT-3522 S1
Unknown
Unknown
 Docetaxel
TUBB
TUBB
10124.002
uM
0.00586
0.00486
 0.1013 0.1330 1.6485 0.5175
0.9891
 2.0795
HMT-3522 S1
Unknown
Unknown
 Doxorubicin
TOP2
TOP
10124.034
uM
0.21725
0.67770
 -0.8261 -0.6580 0.7382 0.5852
0.9382
 2.2594
HMT-3522 S1
Unknown
Unknown
 Doxorubicin
TOP2
TOP
7911.007
uM
3.78730
4.4120
 -0.6482 -0.5728 5.0000 0.3367
0.9890
 1.5549