Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | TNBC | Basal B | PD 98059 | MEK | MAPK | 11850.159 | uM | 160.78440 | 1000.00000 | 0.5303 | -0.5897 | 0.4263 | 0.1253 | 0.6880 | 1.9270 | |
| HCC38 | TNBC | Basal B | PD 98059 | MEK | MAPK | 10578.136 | uM | inf | 25.79330 | 0.5933 | 0.5928 | 4.8756 | 0.0532 | 0.8707 | 1.5577 | |
| HCC38 | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 10578.1 | uM | 8.71610 | 17.04880 | -0.9474 | -1.0000 | 1.6375 | 0.3665 | 0.8880 | 1.6202 | |
| HCC38 | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 7468.093 | uM | 3.78550 | 10.17590 | -0.7786 | -1.0000 | 1.1110 | 0.2905 | 0.8947 | 1.4007 | |
| HCC38 | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 10418.093 | uM | 3.53430 | 7.85550 | -0.9028 | -1.0000 | 1.3755 | 0.2763 | 0.9686 | 0.9872 | |
| HCC38 | TNBC | Basal B | PD184352 | MEK | MAPK | 11850.155 | uM | inf | inf | 0.9060 | 0.9060 | 0.0000 | 0.0877 | 0.0000 | 2.1810 | |
| HCC38 | TNBC | Basal B | PD184352 | MEK | MAPK | 11850.155 | uM | inf | inf | 0.9060 | 0.9060 | 0.0000 | 0.0877 | 0.0000 | 2.1810 | |
| HCC38 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7469.095 | uM | inf | inf | 0.9298 | 0.9298 | 0.0000 | -0.0029 | 0.3387 | 1.8946 | |
| HCC38 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 10418.095 | uM | inf | inf | 0.7496 | 0.7496 | 0.0000 | 0.1450 | 0.4999 | 1.1425 | |
| HCC38 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7468.095 | uM | inf | 10.77520 | 0.9056 | 0.9344 | 4.7741 | 0.0327 | 0.6580 | 1.4474 | |
| HCC38 | TNBC | Basal B | PS-1145 | IKK | NFKB | 10418.065 | uM | inf | inf | 0.7550 | 0.7550 | 0.0000 | 0.0403 | 0.2487 | 0.9401 | |
| HCC38 | TNBC | Basal B | PS-1145 | IKK | NFKB | 7468.065 | uM | inf | inf | 0.8447 | 0.8447 | 0.0000 | 0.0735 | 0.5698 | 1.5219 | |
| HCC38 | TNBC | Basal B | PS-1145 | IKK | NFKB | 7469.065 | uM | inf | 61.95750 | 0.9161 | 0.9150 | 0.8933 | 0.0080 | 0.6490 | 2.0006 | |
| HCC38 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 7468.067 | uM | inf | 14.3580 | 0.7721 | 0.8436 | 4.9310 | 0.0226 | 0.7090 | 1.3847 | |
| HCC38 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 7469.067 | uM | 12.43870 | 9.76010 | 0.2405 | 0.3513 | 5.0000 | 0.1616 | 0.9455 | 2.0639 | |
| HCC38 | TNBC | Basal B | QNZ | NFkB | NFKB | 7468.096 | uM | 0.21256 | 0.03213 | 0.4325 | 0.4677 | 1.4500 | 0.2940 | 0.9839 | 1.5683 | |
| HCC38 | TNBC | Basal B | Ribavirin | 15351.211 | uM | inf | inf | 0.7443 | 0.7443 | 0.0000 | 0.0613 | -0.0247 | 1.0866 | |||
| HCC38 | TNBC | Basal B | Ro 32-0432 | PKC | PKC | 10578.142 | uM | inf | inf | 0.9560 | 0.9560 | 0.0000 | 0.0618 | 0.0539 | 1.8112 | |
| HCC38 | TNBC | Basal B | SB-3CT | MMP2/9 | MMP | 10578.144 | uM | inf | inf | 0.7826 | 0.7826 | 0.0000 | 0.0668 | 0.4813 | 1.6376 | |
| HCC38 | TNBC | Basal B | SB-3CT | MMP2/9 | MMP | 11850.144 | uM | 80.42810 | 339.98370 | 0.4351 | -0.9939 | 0.7593 | 0.0989 | 0.9433 | 1.9379 | |
| HCC38 | TNBC | Basal B | Selumetinib | MEK | MAPK | 11850.155 | uM | inf | inf | 0.9277 | 0.9277 | 0.0000 | 0.0704 | 0.0489 | 2.1810 | |
| HCC38 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 10578.141 | uM | 15.45350 | 25.19440 | -0.8095 | -1.0000 | 2.2476 | 0.2500 | 0.9606 | 1.5679 | |
| HCC38 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 11850.158 | uM | 10.3470 | 20.16870 | -0.7560 | -1.0000 | 1.6460 | 0.2433 | 0.9906 | 1.9855 | |
| HCC38 | TNBC | Basal B | Sirolimus | MTOR | MTOR | 9028.068 | uM | inf | inf | -0.4589 | -0.4589 | 0.0000 | 0.6455 | 0.4044 | 1.2240 | |
| HCC38 | TNBC | Basal B | Sirolimus | MTOR | MTOR | 7854.068 | uM | 0.44605 | 993.87220 | -0.0308 | -0.8745 | 0.1312 | 0.4907 | 0.6533 | 1.3310 |