Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | TNBC | Basal B | Sirolimus | MTOR | MTOR | 7469.069 | uM | inf | 0.00397 | 0.3547 | 0.5089 | 0.6135 | 0.3258 | 0.8425 | 1.8642 | |
| HCC38 | TNBC | Basal B | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7469.084 | uM | 374.9950 | 505.48660 | -0.8498 | -0.9999 | 3.6789 | 0.1928 | 0.9806 | 2.0377 | |
| HCC38 | TNBC | Basal B | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7468.085 | uM | 71.04290 | 101.40680 | -0.9520 | -1.0000 | 3.0872 | 0.2090 | 0.9885 | 1.4385 | |
| HCC38 | TNBC | Basal B | Sulindac sulfide | COX1/2 | COX | 10578.136 | uM | inf | inf | 0.9611 | 0.9611 | 0.0000 | 0.0425 | 0.1972 | 1.5577 | |
| HCC38 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7469.067 | uM | 4.7030 | 7.54930 | -0.9189 | -0.9100 | 2.1906 | 0.4735 | 0.9978 | 2.0639 | |
| HCC38 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7468.067 | uM | 5.17550 | 6.41080 | -0.9839 | -0.9581 | 5.0000 | 0.4887 | 0.9983 | 1.3847 | |
| HCC38 | TNBC | Basal B | TAPI-0 | TACE/Collagenase | 7468.096 | uM | inf | inf | 0.8558 | 0.8558 | 0.0000 | 0.0572 | 0.4094 | 1.5683 | ||
| HCC38 | TNBC | Basal B | Taxol | TUBB | TUBB | 9469.002 | uM | 0.00695 | 0.00973 | -0.6045 | -0.5250 | 2.1282 | 0.9611 | 0.9959 | 1.1541 | |
| HCC38 | TNBC | Basal B | Taxol | TUBB | TUBB | 9453.002 | uM | 0.00667 | 0.01032 | -0.5756 | -0.5492 | 1.6962 | 0.9840 | 0.9969 | 1.2655 | |
| HCC38 | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 10578.14 | uM | 0.11228 | 0.15781 | -0.8269 | -0.7048 | 2.5834 | 0.7192 | 0.9859 | 1.6718 | |
| HCC38 | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 11850.159 | uM | 0.09719 | 0.14720 | -0.8558 | -0.7705 | 2.2467 | 0.7489 | 0.9948 | 1.9270 | |
| HCC38 | TNBC | Basal B | TCS PIM-1 1 | Pim kinase | PIM | 10578.135 | uM | inf | inf | 0.9081 | 0.9081 | 0.0000 | 0.0395 | 0.0248 | 1.7650 | |
| HCC38 | TNBC | Basal B | TCS PIM-1 1 | Pim kinase | PIM | 11850.135 | uM | 112.86870 | 391.75560 | 0.4387 | -1.0000 | 0.8828 | 0.0852 | 0.9523 | 1.9060 | |
| HCC38 | TNBC | Basal B | Temsirolimus | MTOR | MTOR | 10578.144 | uM | inf | inf | -0.8988 | -0.8988 | 0.0000 | 0.5510 | 0.5447 | 1.6376 | |
| HCC38 | TNBC | Basal B | Temsirolimus | MTOR | MTOR | 11850.144 | uM | 0.87441 | 42.32710 | -0.4749 | -1.0000 | 0.2832 | 0.4618 | 0.8367 | 1.9379 | |
| HCC38 | TNBC | Basal B | Topotecan | TOP1 | TOP | 10268.007 | uM | 0.00355 | 0.00556 | -0.7595 | -0.6170 | 1.7917 | 1.2327 | 0.8728 | 1.3306 | |
| HCC38 | TNBC | Basal B | Topotecan | TOP1 | TOP | 9469.121 | uM | 0.00096 | 0.00177 | -0.7010 | -0.7334 | 1.4902 | 1.4796 | 0.9951 | 1.1298 | |
| HCC38 | TNBC | Basal B | Topotecan | TOP1 | TOP | 9453.121 | uM | 0.00675 | 0.01247 | -0.7700 | -0.7895 | 1.5419 | 1.2627 | 0.9994 | 1.2860 | |
| HCC38 | TNBC | Basal B | Torkinib | 15351.211 | uM | 0.00026 | 0.00145 | -0.9254 | -0.8879 | 0.5960 | 1.4733 | 0.9779 | 1.0866 | |||
| HCC38 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 11850.16 | uM | 0.16510 | 0.47277 | -0.5340 | -0.4837 | 0.6432 | 0.4725 | 0.9405 | 1.8797 | |
| HCC38 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10578.138 | uM | 0.45998 | 5.02680 | -0.7596 | -1.0000 | 0.4594 | 0.5328 | 0.9576 | 1.7866 | |
| HCC38 | TNBC | Basal B | TPCA-1 | IKK | NFKB | 10418.093 | uM | 1.68360 | 2.28160 | -0.5847 | -0.5097 | 2.3123 | 0.4267 | 0.9884 | 0.9872 | |
| HCC38 | TNBC | Basal B | TPCA-1 | IKK | NFKB | 10578.1 | uM | 3.68730 | 5.95590 | -0.4761 | -0.4659 | 1.3732 | 0.3713 | 0.9901 | 1.6202 | |
| HCC38 | TNBC | Basal B | TPCA-1 | IKK | NFKB | 7468.093 | uM | 4.17470 | 5.11790 | -0.3703 | -0.3742 | 2.7426 | 0.2799 | 0.9957 | 1.4007 | |
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 9028.05 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0399 | -2.6337 | 0.9299 |