Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 7854.05 | uM | inf | inf | 0.8124 | 0.8124 | 0.0000 | 0.0613 | -0.0181 | 1.0664 | |
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 9453.012 | uM | inf | inf | 0.9034 | 0.9034 | 0.0000 | -0.0001 | 0.4116 | 1.2055 | |
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 9469.024 | uM | 20.76870 | 18.58140 | 0.7090 | 0.2134 | 4.9999 | 0.0060 | 0.8310 | 1.0746 | |
| HCC38 | TNBC | Basal B | Trastuzumab | HER2 | ErbB | 9469.026 | uM | inf | inf | 0.8380 | 0.8380 | 0.0000 | 0.0264 | 0.4874 | 1.2092 | |
| HCC38 | TNBC | Basal B | Trastuzumab | HER2 | ErbB | 10268.122 | uM | 3.49450 | 1.70630 | 0.4865 | 0.4861 | 4.9935 | 0.0343 | 0.6574 | 0.6345 | |
| HCC38 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 10418.065 | uM | 7.46270 | 11.54670 | -0.9677 | -0.9653 | 2.4633 | 0.9555 | 0.9917 | 0.9401 | |
| HCC38 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 7469.065 | uM | 6.6810 | 8.9210 | -0.7039 | -0.6298 | 2.8193 | 0.7864 | 0.9967 | 2.0006 | |
| HCC38 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 7468.065 | uM | 5.63450 | 8.75860 | -0.8821 | -0.8543 | 2.2588 | 0.9332 | 0.9979 | 1.5219 | |
| HCC38 | TNBC | Basal B | Triciribine | AKT | AKT | 7468.074 | uM | 0.29265 | 0.28992 | 0.0167 | 0.0229 | 5.0000 | 0.4113 | 0.8951 | 1.5027 | |
| HCC38 | TNBC | Basal B | Triciribine | AKT | AKT | 7469.074 | uM | 1.93740 | 2.47520 | 0.0995 | -0.0812 | 0.6143 | 0.2290 | 0.9851 | 1.9843 | |
| HCC38 | TNBC | Basal B | Valproic acid | HDAC | HDAC | 10578.143 | uM | 549.94360 | 1000.00000 | -0.8934 | -0.6490 | 1.3915 | 0.3368 | 0.9410 | 1.6935 | |
| HCC38 | TNBC | Basal B | Valproic acid | HDAC | HDAC | 11850.143 | uM | 675.71620 | 1000.00000 | -0.7673 | -0.5833 | 1.9725 | 0.3298 | 0.9647 | 2.1044 | |
| HCC38 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 7854.018 | uM | 0.01793 | 0.03910 | -0.9604 | -0.5785 | 0.9861 | 0.8649 | 0.9206 | 1.2298 | |
| HCC38 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 9453.125 | uM | 0.00620 | 0.01677 | -0.9551 | -0.7105 | 0.8888 | 1.2796 | 0.9343 | 1.2351 | |
| HCC38 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 9028.018 | uM | 0.00890 | 0.01030 | -0.9593 | -0.5379 | 4.9999 | 1.0110 | 0.9456 | 1.0242 | |
| HCC38 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 10418.065 | uM | 12.43020 | 34.13860 | -0.9682 | -1.0000 | 1.0874 | 1.0503 | 0.9666 | 0.9401 | |
| HCC38 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 7468.065 | uM | 34.54050 | 65.85140 | -0.8710 | -0.8811 | 1.5746 | 0.8521 | 0.9963 | 1.5219 | |
| HCC38 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 7469.065 | uM | 56.36950 | 98.13920 | -0.6634 | -0.6778 | 1.5453 | 0.6859 | 0.9993 | 2.0006 | |
| HCC38 | TNBC | Basal B | XRP44X | ELK3 | MAPK | 11850.157 | uM | 1.56040 | 1.50450 | 0.0343 | 0.0323 | 1.8299 | 0.3682 | 0.9769 | 2.0943 | |
| HCC38 | TNBC | Basal B | XRP44X | ELK3 | MAPK | 10578.139 | uM | 2.01990 | 2.47790 | -0.2396 | -0.2200 | 1.7843 | 0.3676 | 0.9952 | 1.6434 | |
| HCC38 | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14212.189 | uM | 0.57153 | 0.70512 | -0.9392 | -0.9291 | 5.0000 | 0.6807 | 0.9965 | 1.6254 | |
| HCC38 | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14616.189 | uM | 0.54715 | 0.67584 | -0.9421 | -0.9367 | 4.9967 | 0.6858 | 0.9977 | 1.4258 | |
| HCC38 | TNBC | Basal B | ZM-447439 | AURK | AURK | 10578.138 | uM | 0.49764 | 0.43283 | 0.0459 | 0.1397 | 2.3483 | 0.4024 | 0.9609 | 1.7866 | |
| HCC38 | TNBC | Basal B | ZM-447439 | AURK | AURK | 11850.16 | uM | 0.41442 | 0.46153 | -0.2903 | -0.1814 | 2.8754 | 0.5113 | 0.9776 | 1.8797 | |
| HCC70 | TNBC | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7860.016 | uM | 23.70830 | 7.16980 | 0.1286 | 0.4987 | 5.0000 | 0.1399 | 0.5753 | 0.6145 |