Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | TNBC | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7857.016 | uM | inf | 1.07040 | 0.8227 | 0.8201 | 0.3309 | 0.0719 | 0.7039 | 1.2049 | ||
| HCC70 | TNBC | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7856.016 | uM | inf | 11.83740 | 0.7410 | 0.6982 | 0.6309 | 0.0644 | 0.8127 | 0.9156 | ||
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 7857.05 | uM | 0.23622 | 0.5610 | -0.7270 | -0.5588 | 0.8674 | 0.5956 | 0.9710 | 1.2527 | |
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 9501.037 | uM | 0.09612 | 0.17225 | -0.8715 | -0.6403 | 1.4131 | 0.7656 | 0.9730 | 0.9998 | |
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 7860.04 | uM | 0.34657 | 0.65539 | -0.9301 | -0.7145 | 1.3929 | 0.6411 | 0.9795 | 0.7003 | |
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 7856.05 | uM | 0.15684 | 0.27566 | -0.8736 | -0.7355 | 1.6039 | 0.7588 | 0.9920 | 0.7346 | |
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 7857.037 | uM | 0.43350 | 0.60928 | -0.4713 | -0.3812 | 1.6648 | 0.5273 | 0.9933 | 1.1628 | |
| HCC70 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 12400.143 | uM | 198.37950 | 1000.00000 | -0.1208 | -0.5081 | 0.4335 | 0.2997 | 0.9432 | 1.3002 | |
| HCC70 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 10873.143 | uM | 200.95550 | 1000.00000 | -0.1837 | -0.6154 | 0.5000 | 0.2961 | 0.9812 | 1.2785 | |
| HCC70 | TNBC | Basal A | 5-FU | TYMS | TYMS | 7857.017 | uM | 64.75590 | 188.94070 | -0.9642 | -1.0000 | 1.0260 | 0.8100 | 0.9595 | 1.1840 | |
| HCC70 | TNBC | Basal A | 5-FU | TYMS | TYMS | 9501.03 | uM | 119.68470 | 224.99790 | -0.9966 | -1.0000 | 1.7404 | 0.7253 | 0.9866 | 0.6902 | |
| HCC70 | TNBC | Basal A | 5-FU | TYMS | TYMS | 7860.017 | uM | 74.51840 | 115.49170 | -0.9988 | -0.9823 | 2.4803 | 0.8191 | 0.9927 | 0.6196 | |
| HCC70 | TNBC | Basal A | Afatinib | EGFR/HER2 | ErbB | 12400.165 | uM | 0.56664 | 1.99750 | -0.9431 | -1.0000 | 0.8720 | 0.6295 | 0.9594 | 1.3057 | |
| HCC70 | TNBC | Basal A | AG1024 | IGF1R | RTK | 7470.066 | uM | 5.18530 | 4.760 | 0.1014 | 0.0926 | 2.3939 | 0.2000 | 0.9212 | 1.0766 | |
| HCC70 | TNBC | Basal A | AG1478 | EGFR | ErbB | 7857.016 | uM | inf | 0.30682 | 0.6747 | 0.6797 | 0.5291 | 0.1620 | 0.7698 | 1.2049 | |
| HCC70 | TNBC | Basal A | AG1478 | EGFR | ErbB | 7860.016 | uM | 4.60020 | 18.35640 | -0.9915 | -1.0000 | 0.7939 | 0.3786 | 0.9507 | 0.6145 | |
| HCC70 | TNBC | Basal A | AG1478 | EGFR | ErbB | 7856.016 | uM | 54.43320 | 94.66480 | -0.5164 | -1.0000 | 1.9853 | 0.1880 | 0.9513 | 0.9156 | |
| HCC70 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 10873.153 | uM | 26.8590 | 241.05320 | 0.4177 | -1.0000 | 0.5006 | 0.1157 | 0.8782 | 1.3397 | |
| HCC70 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 12400.165 | uM | 19.42720 | 80.2540 | 0.3114 | -1.0000 | 0.7745 | 0.1138 | 0.9350 | 1.3057 | |
| HCC70 | TNBC | Basal A | Baicalein | Lipoxygenase | Metabolism | 7470.073 | uM | 167.46080 | 168.94390 | 0.5033 | -0.0221 | 4.9128 | 0.0440 | 0.9725 | 1.2165 | |
| HCC70 | TNBC | Basal A | Baicalein | Lipoxygenase | Metabolism | 10873.072 | uM | 109.83770 | 108.97250 | 0.2046 | 0.0130 | 3.3308 | 0.0185 | 0.9781 | 1.1824 | |
| HCC70 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 14739.203 | uM | 0.00093 | 0.00145 | -0.9973 | -0.9997 | 2.4844 | 1.6705 | 0.9952 | 0.6862 | |
| HCC70 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 14739.203 | uM | 0.00093 | 0.00145 | -0.9973 | -0.9997 | 2.4844 | 1.6705 | 0.9952 | 0.6862 | |
| HCC70 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 7470.074 | uM | 0.01174 | 0.01593 | -0.9855 | -0.9872 | 3.5670 | 1.4267 | 0.9982 | 0.9618 | |
| HCC70 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 7470.074 | uM | 0.01174 | 0.01593 | -0.9855 | -0.9872 | 3.5670 | 1.4267 | 0.9982 | 0.9618 |