Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC3153 | TNBC | Basal A | Trametinib | MEK | MAPK | 10056.012 | uM | inf | 1000.00000 | 0.7725 | -0.2424 | 0.4004 | 0.0559 | 0.6645 | 0.9543 | |
| HCC3153 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 7465.065 | uM | 17.61180 | 29.02440 | -0.8618 | -0.7693 | 1.8649 | 0.7036 | 0.9953 | 1.2013 | |
| HCC3153 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 7466.065 | uM | 29.78540 | 50.15440 | -0.9635 | -0.9079 | 1.9866 | 0.6966 | 0.9953 | 0.8210 | |
| HCC3153 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 7467.065 | uM | 21.7630 | 37.61750 | -0.9105 | -0.8528 | 1.8187 | 0.6804 | 0.9975 | 1.2393 | |
| HCC3153 | TNBC | Basal A | Triciribine | AKT | AKT | 7466.074 | uM | 0.35341 | 0.32322 | 0.2208 | 0.1801 | 5.0000 | 0.3244 | 0.8875 | 0.9724 | |
| HCC3153 | TNBC | Basal A | Triciribine | AKT | AKT | 7467.074 | uM | 0.24441 | 1.67330 | -0.2225 | -0.5644 | 0.3927 | 0.4313 | 0.9791 | 1.2457 | |
| HCC3153 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 10937.143 | uM | 837.1480 | 1000.00000 | -0.6312 | -0.1533 | 1.5042 | 0.1665 | 0.7608 | 1.3133 | |
| HCC3153 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 10577.143 | uM | 780.06890 | 1000.00000 | -0.8241 | -0.3308 | 2.0443 | 0.2225 | 0.8092 | 0.9750 | |
| HCC3153 | TNBC | Basal A | Vinorelbine | TUBB | TUBB | 7853.042 | uM | 0.02995 | 0.03116 | -0.5740 | -0.0878 | 4.1140 | 0.6263 | 0.8449 | 1.7624 | |
| HCC3153 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 7465.065 | uM | 162.79760 | 302.42340 | -0.6283 | -0.6258 | 1.3105 | 0.5501 | 0.9887 | 1.2013 | |
| HCC3153 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 7467.065 | uM | 166.49370 | 309.55030 | -0.7441 | -0.7295 | 1.4508 | 0.5208 | 0.9959 | 1.2393 | |
| HCC3153 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 7466.065 | uM | 104.29160 | 204.51880 | -0.8125 | -0.7820 | 1.3981 | 0.6287 | 0.9966 | 0.8210 | |
| HCC3153 | TNBC | Basal A | XRP44X | ELK3 | MAPK | 10937.151 | uM | 1.17960 | 2.12280 | -0.3035 | -0.3400 | 0.8830 | 0.4370 | 0.9858 | 1.5219 | |
| HCC3153 | TNBC | Basal A | XRP44X | ELK3 | MAPK | 10577.139 | uM | 3.47770 | 3.82410 | -0.3581 | -0.3033 | 4.9927 | 0.3562 | 0.9944 | 0.9234 | |
| HCC3153 | TNBC | Basal A | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14131.189 | uM | 0.44518 | 0.71071 | -0.9115 | -0.9112 | 2.2180 | 0.6899 | 0.9984 | 1.2288 | |
| HCC3153 | TNBC | Basal A | ZM-447439 | AURK | AURK | 10577.138 | uM | inf | inf | 0.6876 | 0.6876 | 0.0000 | 0.0865 | 0.3763 | 1.0408 | |
| HCC3153 | TNBC | Basal A | ZM-447439 | AURK | AURK | 10937.15 | uM | 72.81410 | 997.6140 | 0.5754 | -0.5774 | 0.2933 | 0.1313 | 0.9014 | 1.3769 | |
| HCC38 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7854.016 | uM | inf | 7.23080 | 0.3700 | 0.5045 | 5.0000 | 0.1340 | 0.8222 | 0.9074 | ||
| HCC38 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 9028.016 | uM | inf | 0.64162 | 0.7236 | 0.7617 | 4.7985 | 0.0777 | 0.8803 | 1.2348 | ||
| HCC38 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 9453.019 | uM | 50.39440 | 91.7690 | -0.5042 | -1.0000 | 1.8329 | 0.1656 | 0.9890 | 1.1486 | ||
| HCC38 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 9453.037 | uM | 0.06339 | 0.11675 | -0.7652 | -0.5427 | 1.2034 | 0.7790 | 0.9721 | 1.1917 | |
| HCC38 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 9469.037 | uM | 0.09572 | 0.14148 | -0.6467 | -0.4348 | 1.6015 | 0.6945 | 0.9754 | 1.0663 | |
| HCC38 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 7854.05 | uM | 0.04244 | 0.09833 | -0.6260 | -0.5616 | 0.8960 | 0.8389 | 0.9898 | 1.0664 | |
| HCC38 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 9028.05 | uM | 0.03858 | 0.06502 | -0.5325 | -0.4648 | 1.2597 | 0.8089 | 0.9904 | 0.9299 | |
| HCC38 | TNBC | Basal B | 2-deoxyglucose | 12617.177 | uM | 243.13950 | 257.10010 | 0.0218 | -0.0338 | 1.1705 | 0.2324 | 0.9921 | 1.6822 |